LEADER 03042nam 22006015 450 001 9910484565803321 005 20250609110120.0 010 $a3-030-36533-6 024 7 $a10.1007/978-3-030-36533-2 035 $a(CKB)4100000010473987 035 $a(DE-He213)978-3-030-36533-2 035 $a(MiAaPQ)EBC6121826 035 $a(PPN)242979521 035 $a(MiAaPQ)EBC6122106 035 $a(EXLCZ)994100000010473987 100 $a20200221d2020 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFoundations of the Theory of Parthood $eA Study of Mereology /$fby Andrzej Pietruszczak 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XXIII, 285 p. 729 illus., 4 illus. in color.) 225 1 $aTrends in Logic, Studia Logica Library,$x1572-6126 ;$v54 300 $aIncludes index. 311 08$a3-030-36532-8 327 $aForeword -- Chapter I. Introduction -- Chapter II. ?Existentially neutral? theories of parthood -- Chapter III. Theories of parthood with sum existence axioms -- Chapter IV. Theories of parthood without transitivity -- Appendix A. Logic and set theory -- Appendix B. Algebra. 330 $aThis is the first book to systematically study the weak systems of mereology. In its chapters, the author critically analyzes and explains core topics related to mereology, such as parthood without antisymmetry, non-existence of the zero element, and Le?niewski's notion of class and set. The book also delves into three theories of parthood: two concern the sum existence axioms, and the third contends with transitivity of parthood. This is the first systematic analysis of systems of mereology of its kind and is suitable for students, scholars, logicians, and mathematicians who wish to further their knowledge of mereology. Original polish publication ?Podstawy teorii cz??ci? by The Nicolaus Copernicus University Press. 410 0$aTrends in Logic, Studia Logica Library,$x1572-6126 ;$v54 606 $aAnalysis (Philosophy) 606 $aLogic 606 $aAlgebra 606 $aAnalytic Philosophy$3https://scigraph.springernature.com/ontologies/product-market-codes/E39000 606 $aLogic$3https://scigraph.springernature.com/ontologies/product-market-codes/E16000 606 $aAlgebra$3https://scigraph.springernature.com/ontologies/product-market-codes/M11000 615 0$aAnalysis (Philosophy) 615 0$aLogic. 615 0$aAlgebra. 615 14$aAnalytic Philosophy. 615 24$aLogic. 615 24$aAlgebra. 676 $a111.82 676 $a111.82 700 $aPietruszczak$b Andrzej$4aut$4http://id.loc.gov/vocabulary/relators/aut$0922655 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910484565803321 996 $aFoundations of the Theory of Parthood$92070427 997 $aUNINA LEADER 04352nam 2200985z- 450 001 9910557595603321 005 20220111 035 $a(CKB)5400000000043721 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76802 035 $a(oapen)doab76802 035 $a(EXLCZ)995400000000043721 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMarine Natural Products as Anticancer Agents 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (150 p.) 311 08$a3-0365-1820-7 311 08$a3-0365-1819-3 330 $aCancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment. 606 $aMedicine and Nursing$2bicssc 610 $aalga 610 $aanti-cancer 610 $aantitumor 610 $aaplysinopsin analogs 610 $aapoptosis 610 $aastaxanthin 610 $aBH3 mimetics 610 $abioactive compounds 610 $abiscembranoid-type metabolites 610 $aBT20 610 $acancer stem cells 610 $acancer therapy 610 $achronic myeloid leukemia 610 $acolony formation 610 $acytotoxicity 610 $aEhlich's tumor 610 $aenvironment 610 $aepigenetic signaling 610 $aepigenome 610 $aepithelial-mesenchymal transition 610 $aflaccidoxide-13-acetate 610 $agram-scale 610 $ahepatocellular carcinoma 610 $ahydroxyphenylacetic acid 610 $aindole alkaloids 610 $ainflammation 610 $ainflammatory factor production 610 $ainvasion 610 $aLPS-stimulated murine macrophage 610 $amarine source 610 $amarine species 610 $amarine-derived fungus 610 $ameroterpenoids 610 $amigration 610 $amutp53 610 $an/a 610 $anannocystin 610 $aNanog 610 $anatural product 610 $aOct4 610 $aP. purpurogenum 610 $aPenicillium chrysogenum 610 $apolyketide 610 $apontin 610 $aproliferation 610 $aprostate cancer 610 $aSarcophyton digitatum 610 $asecondary metabolites 610 $asiRNA 610 $aSTAT3 610 $aT47D 610 $atotal synthesis 615 7$aMedicine and Nursing 700 $aAlves$b Celso$4edt$01304461 702 $aDiederich$b Marc$4edt 702 $aAlves$b Celso$4oth 702 $aDiederich$b Marc$4oth 906 $aBOOK 912 $a9910557595603321 996 $aMarine Natural Products as Anticancer Agents$93027442 997 $aUNINA LEADER 00952nas 2200337 c 450 001 9910913549503321 005 20251012104620.0 035 $a(DE-599)ZDB2854400-6 035 $a(OCoLC)1301354288 035 $a(DE-101)1099117097 035 $a(CKB)5600000000881513 035 $a(EXLCZ)995600000000881513 100 $a20160502b18991906 |y | 101 0 $ager 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdress- und Gescha?fts-Handbuch von Solbad Frankenhausen 210 31$aFrankenhausen$cEmil Krebs$d1899-1906 210 1$aFrankenhausen$c˜C.œ Werneburg 300 $aReproduktion 608 $aZeitschrift$2gnd-content 676 $a914.3 801 0$b1140 801 1$bDE-101 801 2$b9001 906 $aJOURNAL 912 $a9910913549503321 996 $aAdress- und Geschäfts-Handbuch von Solbad Frankenhausen$94299330 997 $aUNINA