LEADER 02583oam 2200493 450 001 9910484521403321 005 20210515125432.0 010 $a3-030-62565-6 024 7 $a10.1007/978-3-030-62565-8 035 $a(CKB)4100000011610243 035 $a(MiAaPQ)EBC6407557 035 $a(DE-He213)978-3-030-62565-8 035 $a(EXLCZ)994100000011610243 100 $a20210515d2021 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOnce can be enough $edecisive experiments, no replication required /$fAllan Franklin, Ronald L. Laymon 205 $a1st ed. 2021. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (XII, 181 p. 51 illus.) 311 $a3-030-62564-8 327 $aIntroduction -- The Meselson-Stahl Experiment: ?The Most Beautiful Experiment in Biology? -- The Discovery of the Positron -- The Discovery of the Omega Minus Hyperon -- Once Should Have Been Enough: Gregor Mendel, ?Experiments in Plant Hybridization? -- Once Came Close To Being Enough: Electron Polarization and Parity Nonconservation -- The Discovery of Parity Nonconservation -- The Search for the Magnetic Monopole -- Conclusion. 330 $aThere has recently been considerable discussion of a ?replication crisis? in some areas of science. In this book, the authors argue that replication is not a necessary criterion for the validation of a scientific experiment. Five episodes from physics and genetics are used to substantiate this thesis: the Meselson-Stahl experiment on DNA replication, the discoveries of the positron and the omega minus hyperon, Mendel?s plant experiments, and the discovery of parity nonconservation. Two cases in which once wasn?t enough are also discussed, the nondiscovery of parity nonconservation and the search for magnetic monopoles. Reasons why once wasn?t enough are also discussed. 606 $aReplication (Experimental design) 606 $aScience$xExperiments$xHistory 606 $aScience$xExperiments 608 $aElectronic books. 615 0$aReplication (Experimental design) 615 0$aScience$xExperiments$xHistory. 615 0$aScience$xExperiments. 676 $a507.2 700 $aFranklin$b Allan$f1938-$052578 702 $aLaymon Ronald L 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910484521403321 996 $aOnce can be enough$92847258 997 $aUNINA