LEADER 04037nam 22005535 450 001 9910484444203321 005 20230726014546.0 010 $a3-030-40105-7 024 7 $a10.1007/978-3-030-40105-4 035 $a(CKB)4100000011273785 035 $a(MiAaPQ)EBC6188721 035 $a(DE-He213)978-3-030-40105-4 035 $a(PPN)248396668 035 $a(EXLCZ)994100000011273785 100 $a20200501d2020 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDesign and Analysis of Subgroups with Biopharmaceutical Applications /$fedited by Naitee Ting, Joseph C. Cappelleri, Shuyen Ho, (Din) Ding-Geng Chen 205 $a1st ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (404 pages) 225 1 $aEmerging Topics in Statistics and Biostatistics,$x2524-7743 311 $a3-030-40104-9 327 $a1. Data-driven and Confirmatory Subgroup Analysis in Clinical Trials -- 2. Subgroup Analysis ? A View from Industry -- 3. Biomarker-Targeted Confirmatory Trials -- 4. Considerations on Subgroup Analysis in Design and Analysis of Multi-Regional Clinical Trials -- 5. Practical Subgroup Identification Strategies in Late-stage Clinical Trials -- 6. Exploratory Subgroup Identification for Biopharmaceutical Development -- 7. Logical Inference on Treatment Efficacy When Subgroup Exists -- 8. The GUIDE Approach to Subgroup Identification and Inference -- 9. Use of the VG (Virtual Twins Combined with GUIDE) Method in the Development of Precision Medicines -- 10. Subgroups Identification for Tailored Therapies: a System of Methods, a Framework for Consistent Methodology Evaluation, and an Integrated Learn-and-confirm Approach -- 11. Developing and Validating Predictive Classifiers in Randomized Clinical Trials -- 12. Issues Related to Subgroup Analysis -- 13. Subgroup Analysis with Partial Linear Model -- 14. Subgroup Analysis in the 21st Century -- 15. Power of Statistical Tests for Subgroup Analysis in Meta-Analysis -- 16. Heterogeneity and Subgroup Analysis in Network Meta-Analysis. 330 $aThis book provides an overview of the theories and applications on subgroups in the biopharmaceutical industry. Drawing from a range of expert perspectives in academia and industry, this collection offers an overarching dialogue about recent advances in biopharmaceutical applications, novel statistical and methodological developments, and potential future directions. The volume covers topics in subgroups in clinical trial design; subgroup identification and personalized medicine; and general issues in subgroup analyses, including regulatory ones. Included chapters present current methods, theories, and case applications in the diverse field of subgroup application and analysis. Offering timely perspectives from a range of authoritative sources, the volume is designed to have wide appeal to professionals in the pharmaceutical industry and to graduate students and researchers in academe and government. 410 0$aEmerging Topics in Statistics and Biostatistics,$x2524-7743 606 $aBiometry 606 $aPharmaceutical chemistry 606 $aBiostatistics 606 $aPharmaceutics 615 0$aBiometry. 615 0$aPharmaceutical chemistry. 615 14$aBiostatistics. 615 24$aPharmaceutics. 676 $a615.10727 702 $aTing$b Naitee$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCappelleri$b Joseph C$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHo$b Shuyen$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aChen$b (Din) Ding-Geng$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910484444203321 996 $aDesign and Analysis of Subgroups with Biopharmaceutical Applications$92547801 997 $aUNINA