LEADER 06175nam 22009375 450 001 9910484360603321 005 20230125195916.0 010 $a3-030-63234-2 024 7 $a10.1007/978-3-030-63234-2 035 $a(CKB)5590000000486828 035 $a(DE-He213)978-3-030-63234-2 035 $a(MiAaPQ)EBC6636681 035 $a(Au-PeEL)EBL6636681 035 $a(OCoLC)1256238606 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/70782 035 $a(PPN)269152229 035 $a(EXLCZ)995590000000486828 100 $a20210622d2021 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCritical Issues in Head and Neck Oncology $eKey Concepts from the Seventh THNO Meeting /$fedited by Jan B. Vermorken, Volker Budach, C. René Leemans, Jean-Pascal Machiels, Piero Nicolai, Brian O?Sullivan 205 $a1st ed. 2021. 210 $cSpringer Nature$d2021 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (IX, 373 p. 39 illus., 33 illus. in color.) 311 $a3-030-63233-4 327 $aBiomarkers in Head and Neck Squamous Cell Cancer (HNSCC) -- Promising biomarkers for early diagnosis and prognosis prediction in HNS -- Biomarkers to predict radiotherapy toxicity -- Biomarkers for hypoxia, HPVness and proliferation from imaging perspective -- Mechanism of cetuximab resistance and how to overcome it -- The role of liquid biopsy for monitoring disease evolution -- NK cells in immunotherapy: how important are they? -- Biomarkers for immune modulatory treatment in HNSCC -- Primary disease (1) -- Novel approaches in surgical management of HNSCC -- The surgical approach to elderly patients with HNSCC -- The nonsurgical approach to locoregionally advanced HNSCC -- High-dose three-weekly or low-dose weekly cisplatin during radiation, what to prefer? -- Primary disease (2) -- Where and when to use induction chemotherapy? -- Prognostic role of p16/HPV in non-oropharyngeal head and neck cancer -- Is there a role for neoadjuvant targeted and immunotherapies? -- Is there a role for adjuvant targeted and immunotherapies? -- Optimal supportive measures during primary treatment -- Precision Medicine in head and neck cancer: myth or reality -- Recurrent and / or metastatic disease -- Salvage surgery: candidates, safe reconstruction, and results? -- Re-irradiation for local relapses or second primaries: when and how? -- New promising targeted agents in first and second-line settings -- Update of immune therapies in recurrent/metastatic HNSCC -- Special Issue -- Patients with rare head neck cancers: do they need a different approach? .-Nasopharynx cancer -- New epidemiological aspects -- New developments in the management of nasopharyngeal carcinoma -- New drugs for recurrent/metastatic nasopharynx cancer. 330 $aThis open access book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck cancers. Readers will learn about the latest drug developments and epidemiological aspects in cancers ranging from head and neck squamous cell cancer to nasopharynx cancer. Edited by a team of world leaders in head and neck cancer, this volume serves as an easy reference to the head and neck oncology practitioner and provides a contemporary overview for specialists the field. The chapters are based on the latest data presented at the 7th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field. 606 $aOncology   606 $aRadiotherapy 606 $aSurgical oncology 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aRadiotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H29056 606 $aSurgical Oncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H59150 606 $aCàncer de coll$2thub 606 $aCàncer de cap$2thub 606 $aCirurgia oncològica$2thub 608 $aLlibres electrònics$2thub 610 $aOncology 610 $aRadiotherapy 610 $aSurgical Oncology 610 $aInternal Medicine 610 $aRadiology 610 $aSurgery 610 $aNasopharynx cancer 610 $aHead and Neck Squamous Cell Cancer 610 $anon-oropharyngeal head and neck cancer 610 $apredictive biomarkers 610 $aliquid biopsies 610 $ainduction chemotherapy 610 $aimmunotherapy 610 $aprecision medicine 610 $aHNSCC 610 $aOpen Access 615 0$aOncology  . 615 0$aRadiotherapy. 615 0$aSurgical oncology. 615 14$aOncology. 615 24$aRadiotherapy. 615 24$aSurgical Oncology. 615 7$aCàncer de coll 615 7$aCàncer de cap 615 7$aCirurgia oncològica 676 $a616.994 700 $aVermorken$b Jan B$4edt$01354984 702 $aVermorken$b Jan B$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBudach$b Volker$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLeemans$b C. 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