LEADER 04750nam 22007215 450 001 9910484242303321 005 20240208141251.0 010 $a3-030-65817-1 024 7 $a10.1007/978-3-030-65817-5 035 $a(CKB)4100000011918907 035 $a(DE-He213)978-3-030-65817-5 035 $a(MiAaPQ)EBC6606571 035 $a(Au-PeEL)EBL6606571 035 $a(OCoLC)1250313038 035 $a(PPN)255882084 035 $a(EXLCZ)994100000011918907 100 $a20210505d2021 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Pulmonary Neuroepithelial Body Microenvironment $eA Multifunctional Unit in the Airway Epithelium /$fby Inge Brouns, Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (XVIII, 99 p. 22 illus., 21 illus. in color.) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v233 311 $a3-030-65816-3 327 $aPulmonary sensory receptors -- The pulmonary NEB ME is a complex intraepithelial unit -- Studying the pulmonary NEB ME: a multidisciplinary approach -- Functional exploration of the pulmonary NEB ME -- Concluding remarks and future perspectives -- References -- ADDENDUM. 330 $aThis monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors. 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v233 606 $aNeurosciences 606 $aPhysiology 606 $aNeurochemistry 606 $aRespiratory organs$xDiseases 606 $aNeuroscience 606 $aPhysiology 606 $aNeurochemistry 606 $aPneumology 606 $aNervis$2thub 606 $aAparell respiratori$2thub 606 $aCèl·lules mare$2thub 608 $aLlibres electrònics$2thub 615 0$aNeurosciences. 615 0$aPhysiology. 615 0$aNeurochemistry. 615 0$aRespiratory organs$xDiseases. 615 14$aNeuroscience. 615 24$aPhysiology. 615 24$aNeurochemistry. 615 24$aPneumology. 615 7$aNervis 615 7$aAparell respiratori 615 7$aCèl·lules mare 676 $a612.8 700 $aBrouns$b Inge$0894164 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910484242303321 996 $aThe Pulmonary Neuroepithelial Body Microenvironment$91997354 997 $aUNINA