LEADER 03363oam 2200493 450 001 9910484154703321 005 20210617101955.0 010 $a3-030-54630-6 024 7 $a10.1007/978-3-030-54630-4 035 $a(CKB)5410000000054450 035 $a(MiAaPQ)EBC6455849 035 $a(DE-He213)978-3-030-54630-4 035 $a(PPN)252509099 035 $a(EXLCZ)995410000000054450 100 $a20210617d2021 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aIntroduction to antibody engineering /$fFlorian Rüker, Gordana Wozniak-Knopp, editors 205 $a1st ed. 2021. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (VIII, 388 p. 69 illus., 52 illus. in color.) 225 1 $aLearning materials in biosciences 311 $a3-030-54629-2 327 $aChapter 1. Introduction by the editors -- Chapter 2. Antibodies ? A History of their Discovery and Properties -- Chapter 3. Monoclonal Antibodies and Hybridomas -- Chapter 4. Antibody Display Systems -- Chapter 5. Transgenic Animals for the Generation of Human Antibodies -- Chapter 6. Applications of Antibodies in Therapy, Diagnosis & Science -- Chapter 7. Bispecific antibodies -- Chapter 8. Antibody-Drug Conjugates -- Chapter 9. Alternative Binding Scaffolds ? multipurpose binders for applications in basic research and therapy -- Chapter 10: Chimeric antigen receptor (CAR) redirected T cells -- Chapter 11. Improvement of Key Characteristics of Antibodies -- Chapter 12. Engineering therapeutic antibodies for development -- Chapter 13. Eukaryotic expression systems for upstream pro-cessing of monoclonal antibodies -- Chapter 14. Antibody Validation. 330 $aThis highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book?s content is based on lectures for the specializations ?Protein Engineering? and ?Medical Biotechnology? within the Master?s curriculum in ?Biotechnology.? The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master?s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering. 410 0$aLearning materials in biosciences. 606 $aImmunotechnology 606 $aImmunoglobulins 615 0$aImmunotechnology. 615 0$aImmunoglobulins. 676 $a615.37 702 $aRüker$b Florian 702 $aWozniak-Knopp$b Gordana 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910484154703321 996 $aIntroduction to antibody engineering$92804052 997 $aUNINA