LEADER 04341oam 2200505 450 001 9910484074103321 005 20210420080049.0 010 $a3-030-56954-3 024 7 $a10.1007/978-3-030-56954-9 035 $a(CKB)4100000011558800 035 $a(DE-He213)978-3-030-56954-9 035 $a(MiAaPQ)EBC6386061 035 $a(PPN)252510100 035 $a(EXLCZ)994100000011558800 100 $a20210420d2021 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aStem cell therapy for vascular diseases $estate of the evidence and clinical applications /$fTulio Pinho Navarro, Lara Lellis Navarro Minchillo Lopes, Alan Dardik, editors 205 $a1st ed. 2021. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (XII, 425 p. 46 illus., 38 illus. in color.) 311 $a3-030-56953-5 327 $a1. Introduction to Stem Cell Therapy and its Application in Vascular Diseases -- 2. Types And Origin of Stem Cells -- 3. Stem Cell Delivery Techniques for Stroke and Peripheral Artery Disease -- 4. The Ethical Challenges of Stem Cell Therapy in Vascular Disorders -- 5. Bone Marrow-Derived Cells: from the Laboratory to the Clinic -- 6. Angiogenesis: Perspectives From Therapeutic Angiogenesis -- 7. Stem Cell Therapy for Diabetic Foot Ulcers -- 8. Venous Foot and Leg Ulcers -- 9. Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells for Vascular Regeneration -- 10. Mesenchymal Stem Cell and Hematopoietic Stem Cell Transplantation for Vasculitis -- 11. Mesenchymal Stem Cell and Endothelial Progenitor Cell Transplantation for Buerger's Disease -- 12. Changing the Course of Peripheral Arterial Disease Using Adult Stem Progenitor Cells -- 13. Stem Cell Delivery for the Treatment of Arteriovenous Fistula Failure -- 14. Stem Cell Therapy to Improve Acute Myocardial Infarction Remodeling -- 15. Stem Cell Therapy for Stroke -- 16. Use of Stem Cells in the Treatment of Erectile Dysfunction -- 17. Stem Cell Therapy for Ophthalmic Vascular Disease -- 18. Stem Cell Therapy Delivery in Liver Disease -- 19. Stem Cell Therapy for Lymphedema. 330 $aVascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers. 606 $aBlood-vessels$xDiseases$xTreatment 606 $aPeripheral vascular diseases$xTreatment 606 $aStem cells$xTherapeutic use 615 0$aBlood-vessels$xDiseases$xTreatment. 615 0$aPeripheral vascular diseases$xTreatment. 615 0$aStem cells$xTherapeutic use. 676 $a616.1306 702 $aNavarro$b Tulio Pinho 702 $aMinchillo Lopes$b Lara Lellis Navarro 702 $aDardik$b Alan 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910484074103321 996 $aStem Cell Therapy for Vascular Diseases$92585185 997 $aUNINA