LEADER 04297nam 22005175 450 001 9910484057303321 005 20251223131916.0 010 $a3-030-67814-8 024 7 $a10.1007/978-3-030-67814-2 035 $a(CKB)4100000011781584 035 $a(DE-He213)978-3-030-67814-2 035 $a(MiAaPQ)EBC6511506 035 $a(Au-PeEL)EBL6511506 035 $a(OCoLC)1241065847 035 $a(PPN)254719651 035 $a(EXLCZ)994100000011781584 100 $a20210301d2021 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProtein Reviews $eVolume 21 /$fedited by M. Zouhair Atassi 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2021. 215 $a1 online resource (VII, 213 p. 1 illus.) 225 1 $aProtein Reviews,$x2520-1905 ;$v1314 311 08$a3-030-67813-X 320 $aIncludes bibliographical references and index. 327 $aThe Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme -- Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology -- Collagen IV Exploits a Cl- Step Gradient for Scaffold Assembly -- Roles of Slit Ligands and Their Roundabout (Robo) Family of Receptors in Bone Remodeling -- Characterization of C. elegans Chondroitin Proteoglycans and Their Large Functional and Structural Heterogeneity; Evolutionary Aspects on Structural Differences Between Humans and the Nematode- Structural Basis of a Conventional Recognition Mode of IGHV1-69 Rheumatoid Factors -- Regulated Alternative Translocation: A Mechanism Regulating Transmembrane Proteins Through Topological Inversion- Interleukin-36: Structure, Signaling and Function. 330 $aThe Protein Reviews series serves as a publication vehicle for reviews that focus on crucial contemporary and vital aspects of protein structure, function, evolution and genetics. Volumes are published online first, prior to publication in a printed book. Chapters are selected according to their importance to the understanding of biological systems, relevance to the unravelling of issues associated with health and disease, or impact on scientific or technological advances and developments. Volume 21 presents eight review chapters authored by experts in the related fields. The first chapter covers the enzyme squalene monooxygenase and lipid levels and its relevance in health and disease. Chapter two presents a systematic analysis of the structural and functional aspects of heteromeric solute carriers. The third chapter provides a review of the role of CI- in type IV collagen assembly, function, and disease, including future directions for studies. This isfollowed by a summary in chapter four about the recent progress on defining the roles of the Slit-Robo signaling in bone metabolism and the possible roles of the interaction between Robo and neural epidermal growth factor-like proteins. Chapter five discusses recent data about the evolutionary aspects on structural differences between humans and the nematode in relation to previous knowledge of core proteins and GAG-attachment sites in Chn and CS proteoglycans of C.elegans and humans. The sixth chapter summarizes the immunochemical character of the IGHV1-69-derived RFs and the recognition mechanism of the IGHV1-69-derived RFs. Chapter seven covers regulated alternative translocation and its role as an emerging mechanism to regulate transmembrane proteins. Finally, chapter eight reviews current progress on IL-36 protein and biology and novel investigative tools. This volume is intended for research scientists, clinicians, physicians and graduatestudents in the fields of biochemistry, cell biology, molecular biology, immunology and genetics. . 410 0$aProtein Reviews,$x2520-1905 ;$v1314 606 $aProteins 606 $aProteins 615 0$aProteins. 615 14$aProteins. 676 $a547.75 676 $a572.6 702 $aAtassi$b M. Zouhair 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910484057303321 996 $aProtein Reviews$92818198 997 $aUNINA