LEADER 03286oam 2200433 450 001 9910483945903321 005 20210704102344.0 010 $a981-334-799-6 024 7 $a10.1007/978-981-33-4799-1 035 $a(CKB)4100000011763213 035 $a(DE-He213)978-981-33-4799-1 035 $a(MiAaPQ)EBC6478646 035 $a(PPN)253857414 035 $a(EXLCZ)994100000011763213 100 $a20210704d2021 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHematologic malignancies $ecase studies in cytogenetic and molecular genetics /$fManorama Bhargava 205 $a1st ed. 2021. 210 1$aGateway East, Singapore :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (XXVI, 246 p. 232 illus., 114 illus. in color.) 311 $a981-334-798-8 327 $aTechniques in Cytogenetics -- Techniques in Molecular Haematology -- Part: I - Case Studies in Myeloid Malignancies -- Acute Myeloid Leukemia -- Myelodysplastic Syndrome -- Myelodysplastic Syndromes - Myeloproliferative Neoplasms -- Myeloproliferative Neoplasms -- Chronic Myeloid Leukemia -- Next Generation Sequencing for Diagnostics of Myeloid Malignancies for Routine Clinical Use: Pitfalls and Advantages -- Part: II - Case Studies in Lymphoid Malignancies -- Acute Lymphoblastic Leukemia -- Chronic Lymphocytic Leukemia and Non Hodgkin?s Lymphoma -- Part: III - Case Studies in Multiple Myeloma -- Multiple Myeloma. 330 $aThis book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well. 606 $aLeukemia$xGenetic aspects 615 0$aLeukemia$xGenetic aspects. 676 $a616.99416042 700 $aBhargava$b Manorama$01222788 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910483945903321 996 $aHematologic malignancies$92836611 997 $aUNINA