LEADER 05195nam 22006374a 450 001 996214620903316 005 20230617005414.0 010 $a1-280-19691-2 010 $a9786610196913 010 $a0-470-98842-8 010 $a1-4051-4471-8 035 $a(CKB)1000000000342018 035 $a(EBL)233024 035 $a(OCoLC)130848715 035 $a(SSID)ssj0000226491 035 $a(PQKBManifestationID)11200484 035 $a(PQKBTitleCode)TC0000226491 035 $a(PQKBWorkID)10258088 035 $a(PQKB)11040762 035 $a(MiAaPQ)EBC233024 035 $a(EXLCZ)991000000000342018 100 $a20040722d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPreparative enantioselective chromatography$b[electronic resource] /$fedited by Geoffrey B Cox 205 $a1st ed. 210 $aAmes, Iowa $cBlackwell Pub.$d2005 215 $a1 online resource (346 p.) 300 $aDescription based upon print version of record. 311 $a1-4051-1870-9 320 $aIncludes bibliographical references and index. 327 $aPreparative Enantioselective Chromatography; Contents; Contributors; Preface; 1. Chiral chromatography in support of pharmaceutical process research; 1.1 Introduction; 1.2 A brief introduction to chirality; 1.3 Why chirality is important; 1.4 Accessing enantiopurity: a brief overview of approaches; 1.4.1 Enantiopure starting materials: the chiral pool; 1.4.2 Removable enantioenriched auxiliaries; 1.4.3 Enantioselective catalysis; 1.4.4 Resolution technologies: introduction; 1.4.5 Chromatographic productivity is the key metric for preparative chromatography 327 $a1.4.6 Stationary phases for preparative chiral chromatography1.4.7 Advantages of preparative chiral chromatography over other approaches for accessing enantiopure materials; 1.4.8 Simulated moving bed enantioseparation; 1.5 Green enantioseparation; 1.6 What is the appropriate role of preparative chromatography in organic synthesis?; 1.7 Fording the river at the easiest point: some observations on the appropriate placement of a chromatographic resolution within a chiral synthesis; 1.8 Origins of preparative chiral chromatography 327 $a1.9 Practical tips for preparative chromatographic enantioseparation1.10 Conclusion; 2. Introduction to preparative chromatography; 2.1 Introduction; 2.2 Adsorption isotherms; 2.2.1 The simple case - the Langmuir isotherm; 2.2.2 Other isotherms; 2.2.3 Competitive isotherms; 2.3 Kinetics; 2.4 Metrics for preparative operations; 2.4.1 Throughput; 2.4.2 Production rate; 2.4.3 Productivity; 2.4.4 Specific productivity; 2.4.5 Cost; 2.5 The influence of chromatographic parameters on preparative chromatography; 2.5.1 Effect of particle size on preparative performance; 2.5.2 Effects of pressure 327 $a2.5.3 Effects of column efficiency2.5.4 Effect of column length; 2.5.5 The effects of selectivity; 2.6 Economics of preparative separations; 2.6.1 Point of insertion of the chromatographic resolution in the synthetic route; 3 Chiral stationary phases for preparative enantioselective chromatography; 3.1 Summary; 3.2 Introduction; 3.3 Historical development of CSPs for preparative chromatography; 3.4 Preparative CSPs; 3.4.1 Classification of CSPs; 3.4.2 Polymeric phases; 3.4.3 Brush-type CSPs; 3.4.4 Chiral phases for ligand-exchange chromatography; 3.4.5 Imprinted phases 327 $a3.5 Chemical and physical properties of CSPs3.5.1 Loading capacity; 3.5.2 Chemical and physical stability; 3.5.3 Solubility of the chiral solute; 3.6 New and future developments in the field of preparative CSPs; 3.6.1 CSPs with improved loading capacity; 3.6.2 CSPs with improved selectivity; 3.6.3 Immobilised polysaccharide-based CSPs; 3.7 Conclusion; 4 Method development for preparative enantioselective chromatography; 4.1 Introduction; 4.2 Chiral stationary phases for enantioselective chromatography; 4.3 Screening and optimisation strategy for preparative chiral chromatography 327 $a4.3.1 Choice of the stationary phase 330 $aThe development of chiral liquid chromatography, facilitating the straightforward separation of enantiomers, was a significant advance in chromatography, leading to widespread application in analytical chemistry. Application in preparative chromatography has been less rapid, but with the development of single enantiomer pharmaceuticals its use is increasingly common in chemical synthesis at laboratory, pilot plant and even full production scale. Brings non-experts up to speed quickly and comprehensively, facilitating the rapid development of effective separations of enantiomeri 606 $aLiquid chromatography 606 $aEnantiomers$xSeparation 615 0$aLiquid chromatography. 615 0$aEnantiomers$xSeparation. 676 $a543.089 676 $a543.84 676 $a543/.84 701 $aCox$b Geoffrey J.$f1952-$0969193 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996214620903316 996 $aPreparative enantioselective chromatography$92202110 997 $aUNISA LEADER 04420nam 22007575 450 001 9910483849903321 005 20251226200042.0 010 $a3-540-68863-3 024 7 $a10.1007/978-3-540-68863-1 035 $a(CKB)1000000000440608 035 $a(SSID)ssj0000317718 035 $a(PQKBManifestationID)11224130 035 $a(PQKBTitleCode)TC0000317718 035 $a(PQKBWorkID)10295532 035 $a(PQKB)10178704 035 $a(DE-He213)978-3-540-68863-1 035 $a(MiAaPQ)EBC3068609 035 $a(PPN)127048278 035 $a(EXLCZ)991000000000440608 100 $a20100301d2008 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aFormal Methods for Open Object-Based Distributed Systems $e10th IFIP WG 6.1 International Conference, FMOODS 2008, Oslo, Norway, June 4-6, 2008 Proceedings /$fedited by Gilles Barthe 205 $a1st ed. 2008. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2008. 215 $a1 online resource (X, 259 p.) 225 1 $aProgramming and Software Engineering,$x2945-9168 ;$v5051 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a3-540-68862-5 320 $aIncludes bibliographical references and index. 327 $aFormal Methods for Open Object-Based Distributed Systems -- Guiding Distributed Systems Synthesis with Language-Based Security Policies -- Termination Analysis of Java Bytecode -- Sessions and Pipelines for Structured Service Programming -- Modular Preservation of Safety Properties by Cookie-Based DoS-Protection Wrappers -- Behavioural Theory at Work: Program Transformations in a Service-Centred Calculus -- Mechanizing a Correctness Proof for a Lock-Free Concurrent Stack -- Symbolic Step Encodings for Object Based Communicating State Machines -- Modeling and Model Checking Software Product Lines -- Semantic Foundations and Inference of Non-null Annotations -- Redesign of the LMST Wireless Sensor Protocol through Formal Modeling and Statistical Model Checking -- A Minimal Set of Refactoring Rules for Object-Z -- Formal Modeling of a Generic Middleware to Ensure Invariant Properties -- CoBoxes: Unifying Active Objects and Structured Heaps -- VeriCool: An Automatic Verifier for a Concurrent Object-Oriented Language -- A Caller-Side Inline Reference Monitor for an Object-Oriented Intermediate Language. 330 $aThis book constitutes the refereed proceedings of the 10th IFIP WG 6.1 International Conference on Formal Methods for Open Object-Based Distributed Systems, FMOODS 2008, held in Oslo, Norway, in June 2008. The 14 revised full papers presented together with 1 invited lecture were carefully reviewed and selected from 35 submissions. The papers cover topcics such as semantics of object-oriented programming; formal techniques for specification, analysis, and refinement; model checking; theorem proving and deductive verification; type systems and behavioral typing; formal methods for service-oriented computing; integration of quality of service requirements into formal models; formal approaches to component-based design; and applications of formal methods. 410 0$aProgramming and Software Engineering,$x2945-9168 ;$v5051 606 $aComputer networks 606 $aSoftware engineering 606 $aCompilers (Computer programs) 606 $aComputer programming 606 $aOperating systems (Computers) 606 $aComputer Communication Networks 606 $aSoftware Engineering 606 $aCompilers and Interpreters 606 $aProgramming Techniques 606 $aOperating Systems 615 0$aComputer networks. 615 0$aSoftware engineering. 615 0$aCompilers (Computer programs) 615 0$aComputer programming. 615 0$aOperating systems (Computers) 615 14$aComputer Communication Networks. 615 24$aSoftware Engineering. 615 24$aCompilers and Interpreters. 615 24$aProgramming Techniques. 615 24$aOperating Systems. 676 $a004.6 701 $aBarthe$b Gilles$0180568 701 $aBoer$b Frank S. de$0127081 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483849903321 996 $aFormal methods for open object-based distributed systems$94186894 997 $aUNINA