LEADER 03931nam 2200457 450 001 9910483818903321 005 20210330102105.0 010 $a3-030-56510-6 024 7 $a10.1007/978-3-030-56510-7 035 $a(CKB)4100000011558580 035 $a(DE-He213)978-3-030-56510-7 035 $a(MiAaPQ)EBC6384950 035 $a(PPN)252509994 035 $a(EXLCZ)994100000011558580 100 $a20210330d2021 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aComplex systems and computational biology approaches to acute inflammation $ea framework for model-based precision medicine /$fYoram Vodovotz, Gary An, editors 205 $aSecond edition. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$dİ2021 215 $a1 online resource (IX, 312 p. 51 illus., 37 illus. in color.) 300 $aIncludes index. 311 $a3-030-56509-2 327 $a1. An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine -- 2 Translational Equation-based Modeling -- 3. Agent-based Modeling in Translational Systems Biology -- 4. Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -- 5. Therapeutics as Control: Model-based approaches for control discovery -- 6. Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -- 7. Multi-scale equation-based models: Insights for Inflammation and Physiological Variability -- 8. In silico Trials and Personalized Therapy for Sepsis and Trauma -- 9. Computational Modeling of the Coagulation Response -- 10. Disorder of Localized Inflammation in Wound Healing -- 11. Equation-based Models of Wound Healing and Collective Cell Migration -- 12. Agent-based Models of Wound Healing -- 13. Tissue realistic translational modeling of gut inflammation -- 14. Data-Driven Modeling of Liver Injury, Inflammation, and Fibrosis -- 15. Computational Modeling of Tuberculosis -- 16. The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases -- Index. 330 $aThis second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research. 606 $aInflammation$xTreatment 615 0$aInflammation$xTreatment. 676 $a616.0473 702 $aVodovotz$b Yoram 702 $aAn$b Gary 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483818903321 996 $aComplex Systems and Computational Biology Approaches to Acute Inflammation$92513097 997 $aUNINA LEADER 00404nas 2200157z- 450 001 9910875863503321 035 $a(CKB)4920000003130358 035 $a(EXLCZ)994920000003130358 100 $a20240102cuuuuuuuu -u- - 101 0 $aeng 200 00$aCorporate Reputation Review 210 $aEngland 906 $aJOURNAL 912 $a9910875863503321 996 $aCorporate reputation review$92354779 997 $aUNINA