LEADER 05279nam 22006494a 450 001 9910143744003321 005 20170815121636.0 010 $a1-280-27608-8 010 $a9786610276080 010 $a0-470-01112-2 010 $a0-470-01111-4 035 $a(CKB)1000000000356146 035 $a(EBL)239032 035 $a(OCoLC)475950107 035 $a(SSID)ssj0000111592 035 $a(PQKBManifestationID)11137687 035 $a(PQKBTitleCode)TC0000111592 035 $a(PQKBWorkID)10080743 035 $a(PQKB)10017079 035 $a(MiAaPQ)EBC239032 035 $a(EXLCZ)991000000000356146 100 $a20040412d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiocalorimetry 2$b[electronic resource] $eapplications of calorimetry in the biological sciences /$fedited by John E. Ladbury, Michael L. Doyle 205 $a2nd ed. 210 $aChichester ;$aHoboken, NJ $cWiley$dc2004 215 $a1 online resource (277 p.) 300 $aRev. ed. of: Biocalorimetry. 311 $a0-470-84968-1 320 $aIncludes bibliographical references and index. 327 $aBiocalorimetry 2; Contents; Preface; List of Contributors; Part I General Introduction; 1 Applications of Biocalorimetry: Binding, Stability and Enzyme Kinetics; 1.1 Introduction; 1.2 Principles of isothermal titration calorimetry (ITC); 1.3 Applications of ITC in the life sciences; 1.4 Thermodynamic signatures of non-covalent interactions; 1.5 Thermodynamic discrimination (TD); 1.6 ITC as a tool for studying drug-DNA interactions; 1.7 ITC as a tool for studying protein-DNA interactions; 1.8 The application of calorimetry for examining hydration effcts 327 $a1.9 The use of ITC for studying the kinetics and thermodynamics of enzyme catalysis1.10 Principles of differential scanning calorimetry (DSC); 1.11 Applications of DSC in the life sciences; 1.12 Thermodynamic stability; 1.13 Shelf life versus thermodynamic stability; 1.14 Specific and non-specific binding; 1.15 Intrinsic and extrinsic macromolecular stability; 1.16 Oligomerization; 1.17 The use of DSC for examining nucleic acid helix coil transitions; 1.18 Summary; Acknowledgements; References; Part II Isothermal Titration Calorimetry; 2 Isothermal Titration Calorimetry: A Tutorial 327 $a2.1 Introduction2.2 Thermodynamic characterization; 2.3 Instrumentation; 2.4 Raw data; 2.5 Basic considerations for experimental set-up; 2.6 Data analysis; 2.7 Summary; Application notes; Acknowledgement; References; 3 The Application of Isothermal Titration Calorimetry to Drug Discovery; 3.1 Introduction; 3.2 Overview of the drug discovery process; 3.3 Experimental measurement of thermodynamic binding parameters; 3.4 ITC in drug discovery; 3.5 Summary; References; 4 Dissecting the Thermodynamics of DNA-Protein Interactions; 4.1 Introduction; 4.2 Model systems 327 $a4.3 Comparison with the hydrophobic effect4.4 Protonation and charged-charged hydrogen bonds; 4.5 Dissection of the binding entropy; 4.6 Entropy contributions to the Sso7d-DNA interaction; 4.7 Entropy contributions to the GCN4-DNA interaction; 4.8 Discussion; Acknowledgements; References; 5 Salt Effects in Ribonuclease-Ligand Interactions: Screening or Competitive Binding?; 5.1 Introduction; 5.2 Anion binding to a protein-protein complex; 5.3 Charge-charge interactions in ribonuclease binding; 5.4 Conclusions; Acknowledgement; References 327 $a6 Thermodynamics-Structure Correlations of Sulfonamide Inhibitor Binding to Carbonic Anhydrase6.1 Introduction; 6.2 Identification of protonation reactions occurring upon binding; 6.3 Observed thermodynamics of inhibitor binding to CA; 6.4 Energetics of inhibitor protonation; 6.5 Sulfonamide 'anion' binding thermodynamics; 6.6 Correlations between structures and the thermodynamics of sulfonamide binding to CA; 6.7 Conclusions; References; 7 Energetics of the Interaction of Human Acidic Fibroblast Growth Factor with Heparin and the Functional Analogue Myo-Inositol Hexasulfate; 7.1 Introduction 327 $a7.2 Thermodynamic parameter derived from ITC experiments 330 $aOver the last decade, high-sensitivity calorimetry has developed from a specialist method used mainly by dedicated experts to a major, commercially available tool in the arsenal directed at understanding molecular interactions and stability. Calorimeters have now become commonplace in bioscience laboratories. As a result, the number of those proficient in experimentation in this field has risen dramatically, as has the range of experiments to which these methods have been applied. Applications extend from studies in small molecule and solvent biophysics, through drug screening to whole cell as 606 $aCalorimetry 606 $aBiology$xTechnique 608 $aElectronic books. 615 0$aCalorimetry. 615 0$aBiology$xTechnique. 676 $a572.43 676 $a572.436 701 $aLadbury$b John E.$f1960-$0880077 701 $aDoyle$b Michael L.$f1959-$0880078 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143744003321 996 $aBiocalorimetry 2$91965145 997 $aUNINA LEADER 08883nam 22009015 450 001 9910483760303321 005 20251226195538.0 010 $a3-540-76719-3 024 7 $a10.1007/978-3-540-76719-0 035 $a(CKB)1000000000490737 035 $a(SSID)ssj0000318588 035 $a(PQKBManifestationID)11265171 035 $a(PQKBTitleCode)TC0000318588 035 $a(PQKBWorkID)10310450 035 $a(PQKB)11737113 035 $a(DE-He213)978-3-540-76719-0 035 $a(MiAaPQ)EBC4976866 035 $a(MiAaPQ)EBC5576793 035 $a(MiAaPQ)EBC6413386 035 $a(Au-PeEL)EBL4976866 035 $a(CaONFJC)MIL135490 035 $a(OCoLC)1024284604 035 $a(Au-PeEL)EBL5576793 035 $a(OCoLC)191471173 035 $a(PPN)123728975 035 $a(EXLCZ)991000000000490737 100 $a20100301d2007 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aKnowledge Science, Engineering and Management $eSecond International Conference, KSEM 2007, Melbourne, Australia, November 28-30, 2007, Proceedings /$fedited by Zili Zhang, Jörg Siekmann 205 $a1st ed. 2007. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2007. 215 $a1 online resource (XVI, 669 p.) 225 1 $aLecture Notes in Artificial Intelligence,$x2945-9141 ;$v4798 300 $aIncludes index. 311 08$a3-540-76718-5 327 $aInvited Talks -- Building Relationships and Negotiating Agreements in a Network of Agents -- Knowledge Technologies for the Social Semantic Desktop -- Knowledge-Based Intelligent Engineering Systems in Defence and Security -- Auditing and Mapping the Knowledge Assets of Business Processes ? An Empirical Study -- Quotient Space Based Multi-granular Analysis -- Regular Papers -- An Ontology-Based Reasoning Framework for Reaction Mechanisms Simulation -- Identifying Dependency Between Secure Messages for Protocol Analysis -- A Diagrammatic Reasoning System for -- Fuzzy Constraint Logic Programming with Answer Set Semantics -- Prime Implicates for Approximate Reasoning -- Distributed Constraint Satisfaction for Urban Traffic Signal Control -- Convergence Analysis on Approximate Reinforcement Learning -- Combinative Reasoning with RCC5 and Cardinal Direction Relations -- A Merging-Based Approach to Handling Inconsistency in Locally Prioritized Software Requirements -- A Dynamic Description Logic for Representation and Reasoning About Actions -- An Argumentative Reasoning Service for Deliberative Agents -- On Defense Strength of Blocking Defeaters in Admissible Sets -- Ontology-Based Inference for Causal Explanation -- Predicting Partners? Behaviors in Negotiation by Using Regression Analysis -- Enhancing Web-Based Adaptive Learning with Colored Timed Petri Net -- Proof Explanation for the Semantic Web Using Defeasible Logic -- Automatic Construction of a Lexical Attribute Knowledge Base -- Populating CRAB Ontology Using Context-Profile Based Approaches -- Learning Dependency Model for AMP-Activated Protein Kinase Regulation -- Towards a Wrapper-Driven Ontology-Based Framework for Knowledge Extraction -- A Google-Based Statistical Acquisition Model of Chinese Lexical Concepts -- LearningConcepts from Text Based on the Inner-Constructive Model -- Contextual Proximity Based Term-Weighting for Improved Web Information Retrieval -- Collection Profiling for Collection Fusion in Distributed Information Retrieval Systems -- Integration of Descriptors for Software Component Retrieval -- Framework for Text-Based Conversational User-Interface for Business Applications -- Ontology Mining for Semantic Interpretation of Information Needs -- Knowledge Flow-Based Document Recommendation for Knowledge Sharing -- Finding Similar RSS News Articles Using Correlation-Based Phrase Matching -- Automatic Data Record Detection in Web Pages -- Visualizing Trends in Knowledge Management -- Constructing an Ontology for a Research Program from a Knowledge Science Perspective -- An Ontology of Problem Frames for Guiding Problem Frame Specification -- A Speaker Based Unsupervised Speech Segmentation Algorithm Used in Conversational Speech -- Distributed Knowledge Management Based on Ontological Engineering and Multi-Agent System Towards Semantic Interoperation -- WTPMiner: Efficient Mining of Weighted Frequent Patterns Based on Graph Traversals -- Development of Enhanced Data Mining System to Approximate Empirical Formula for Ship Design -- Research on a Novel Word Co-occurrence Model and Its Application -- Cost-Time Sensitive Decision Tree with Missing Values -- Knowledge in Product and Performance Support -- What Drives Members to Continue Sharing Knowledge in a Virtual Professional Community? The Role of Knowledge Self-efficacy and Satisfaction -- MMFI_DSSW ? A New Method to Incrementally Mine Maximal Frequent Itemsets in Transaction Sensitive Sliding Window -- Short Papers -- Term Consistency Checking of Ontology Model Based on Description Logics -- Design and Realization of AdvertisementPromotion Based on the Content of Webpage -- Irregular Behavior Recognition Based on Two Types of Treading Tracks Under Particular Scenes -- Ontology-Based Focused Crawling of Deep Web Sources -- Pattern Recognition in Stock Data Based on a New Segmentation Algorithm -- HMM-Based Korean Named Entity Recognition for Information Extraction -- Activity Recognition Based on Hidden Markov Models -- Novel Data Management Algorithms in Peer-to-Peer Content Distribution Networks -- On-Line Monitoring and Diagnosis of Failures Using Control Charts and Fault Tree Analysis (FTA) Based on Digital Production Model -- An Improved NN-SVM Based on K Congener Nearest Neighbors Classification Algorithm -- Handling Contradictions in Default Theories -- Algorithm for Public Transit Trip with Minimal Transfer Times and Shortest Travel Time -- Typed Category Theory-Based Micro-view Emergency Knowledge Representation -- A Chinese Time Ontology -- Toward Patterns for Collaborative Knowledge Creation -- Service-Mining Based on Knowledge and Customer Databases -- A Multi-criteria Decision Support System of Water Resource Allocation Scenarios -- Gödel, Escher, Bach and Super-expertise -- Extracting Features for Verifying WordNet -- A Hybrid Approach for Learning Markov Equivalence Classes of Bayesian Network -- A WSMO-Based Semantic Web Services Discovery Framework in Heterogeneous Ontologies Environment -- Cardinal Direction Relations in 3D Space -- Knowledge Integration on Fresh Food Management -- An Approach to Knowledge Transferring in Science-Policy Process -- Trust Analysis of Web Services Based on a Trust Ontology -- Building Bilingual Ontology from WordNet and Chinese Classified Thesaurus -- An Ontology-Based Framework for Building Adaptable Knowledge Management Systems -- Knowledge Engineering Technique forCluster Development. 330 $aThis book constitutes the refereed proceedings of the Second International Conference on Knowledge Science, Engineering and Management, KSEM 2007, held in Melbourne, Australia, in November 2007. The 42 revised full papers and 28 revised short papers presented together with 5 invited talks were carefully reviewed and selected from 124 submissions. The papers provide new ideas and report state of the art research results in the broad areas of knowledge science, knowledge engineering, and knowledge management. 410 0$aLecture Notes in Artificial Intelligence,$x2945-9141 ;$v4798 606 $aArtificial intelligence 606 $aData mining 606 $aApplication software 606 $aDatabase management 606 $aPattern recognition systems 606 $aArtificial Intelligence 606 $aData Mining and Knowledge Discovery 606 $aComputer and Information Systems Applications 606 $aDatabase Management 606 $aAutomated Pattern Recognition 615 0$aArtificial intelligence. 615 0$aData mining. 615 0$aApplication software. 615 0$aDatabase management. 615 0$aPattern recognition systems. 615 14$aArtificial Intelligence. 615 24$aData Mining and Knowledge Discovery. 615 24$aComputer and Information Systems Applications. 615 24$aDatabase Management. 615 24$aAutomated Pattern Recognition. 676 $a006.33 686 $a004$2sdnb 686 $aDAT 616f$2stub 686 $aDAT 620f$2stub 686 $aDAT 703f$2stub 686 $aDAT 825f$2stub 686 $aSS 4800$2rvk 702 $aZhang$b Zili 702 $aSiekmann$b Jorg H. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483760303321 996 $aKnowledge Science, Engineering and Management$9772454 997 $aUNINA