LEADER 04887nam 2200685 450 001 9910483588903321 005 20230329125437.0 010 $a981-336-013-5 024 7 $a10.1007/978-981-33-6013-6 035 $a(CKB)4100000011786637 035 $a(DE-He213)978-981-33-6013-6 035 $a(MiAaPQ)EBC6511391 035 $a(Au-PeEL)EBL6511391 035 $a(OCoLC)1241451196 035 $a(PPN)254723632 035 $a(EXLCZ)994100000011786637 100 $a20211005d2021 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular diagnosis and targeting for gynecologic malignancy /$fSeiji Isonishi, Yoshihiro Kikuchi, editors 205 $a1st ed. 2021. 210 1$aGateway East, Singapore :$cSpringer,$d[2021] 210 4$dŠ2021 215 $a1 online resource (VIII, 165 pages, 26 illustrations., 24 illustrations in color) 225 1 $aCurrent Human Cell Research and Applications,$x2522-073X 311 $a981-336-012-7 320 $aIncludes bibliographical references. 327 $a1 Cancer Stem Cells in gynecologic cancer -- 2 Patient-derived xenograft models in gynaecological malignancies -- 3 Cancer genomic profiling of gynecological malignancies by Todai OncoPanel, a twin DNA and RNA panel -- 4 Investigating the molecular carcinogenesis of ovarian high-grade serous cancer -- 5 The role of G protein-coupled receptor signaling in gynecologic malignancy -- 6 Tailor-made therapy according genetic alteration in epithelial ovarian cancers -- 7 Signaling and drug resistance -- 8 Molecular analysis in endometrial carcinoma -- 9 Molecular Landscape in Ovarian Clear Cell Carcinoma -- 10 Molecular pathology and clinicopathological significance of endometrial carcinoma -- 11 Novel approach for therapeutics of cervical cancer based on HPV-associated carcinogenesis at the cervix -- 12 Hereditary gynecological malignancy and molecular features. 330 $aThis book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases. 410 0$aCurrent Human Cell Research and Applications,$x2522-073X 606 $aGenerative organs, Female$xCancer 606 $aGenital Neoplasms, Female 606 $aOvarian Neoplasms 606 $aUterine Cervical Neoplasms 606 $aCāncer$2thub 606 $aMalalties de l'aparell genital femení$2thub 606 $aCāncer d'ovari$2thub 606 $aCāncer d'úter$2thub 608 $aLlibres electrōnics$2thub 615 0$aGenerative organs, Female$xCancer. 615 2$aGenital Neoplasms, Female. 615 2$aOvarian Neoplasms. 615 2$aUterine Cervical Neoplasms. 615 7$aCāncer 615 7$aMalalties de l'aparell genital femení 615 7$aCāncer d'ovari 615 7$aCāncer d'úter 676 $a616.99465 702 $aIsonishi$b Seiji 702 $aKikuchi$b Yoshihiro 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483588903321 996 $aMolecular diagnosis and targeting for gynecologic malignancy$91907183 997 $aUNINA