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100   $a20220201d2021      uy             0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aProteoglycans in stem cells $efrom development to cancer /$fMartin Go?tte, Karin Forsberg-Nilsson, editors
205   $a1st ed. 2021.
210  1$aCham, Switzerland :$cSpringer,$d[2021]
210  4$d©2021
215   $a1 online resource (XI, 308 p. 51 illus., 46 illus. in color.)
225 1 $aBiology of Extracellular Matrix ;$vVolume 9
311   $a3-030-73452-8 
327   $aChapter 1: Heparan Sulfate Proteoglycans in the Stem Cell Niche: Lessons from Drosophila -- Chapter 2: Proteoglycans in zebrafish development -- Chapter 3: The pivotal role of versican turnover by ADAMTS proteases in mammalian reproduction and development -- Chapter 4: Use of chondroitin sulfate to aid in vitro stem cell differentiation -- Chapter 5: Regulatory functions of heparan sulfate in stem cell self-renewal and differentiation -- Chapter 6: Proteoglycans as mediators of neurogenesis and stem cell differentiation -- Chapter 7: Syndecan-3: a signaling conductor in the musculoskeletal system -- Chapter 8: Proteoglycans of the neural stem cell niche -- Chapter 9: Heparan sulfate in normal and cancer stem cells of the brain -- Chapter 10: Hyaluronic acid-CD44 interaction in the physio- and pathological stem cell niche -- Chapter 11: Proteoglycans in glioma stem cells -- Chapter 12: Role of Syndecan-1 in Cancer Stem cells.
330   $aThis book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
410  0$aBiology of extracellular matrix ;$vVolume 9.
606   $aProteoglycans
606   $aGlycosaminoglycans
606   $aStem cells
606   $aStem Cells
606   $aProteoglycans
606   $aGlicoproteïnes$2thub
606   $aBiomolècules$2thub
606   $aCèl·lules mare$2thub
608   $aLlibres electrònics$2thub
615  0$aProteoglycans.
615  0$aGlycosaminoglycans.
615  0$aStem cells.
615  2$aStem Cells.
615  2$aProteoglycans
615  7$aGlicoproteïnes
615  7$aBiomolècules
615  7$aCèl·lules mare
676   $a572.68
702   $aGo?tte$b Martin
702   $aForsberg-Nilsson$b Karin
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910483438803321
996   $aProteoglycans in Stem Cells$92209016
997   $aUNINA