LEADER 05170nam 22006135 450 001 9910483213003321 005 20200704005713.0 010 $a0-387-30398-7 024 7 $a10.1007/978-0-387-30398-7 035 $a(CKB)1000000000393879 035 $a(SSID)ssj0000318051 035 $a(PQKBManifestationID)11267546 035 $a(PQKBTitleCode)TC0000318051 035 $a(PQKBWorkID)10308084 035 $a(PQKB)11353298 035 $a(DE-He213)978-0-387-30398-7 035 $a(MiAaPQ)EBC3062620 035 $a(MiAaPQ)EBC6311455 035 $a(MiAaPQ)EBC5594000 035 $a(Au-PeEL)EBL5594000 035 $a(OCoLC)1076264214 035 $a(PPN)123732948 035 $a(EXLCZ)991000000000393879 100 $a20100301d2008 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aHandbook of Neurochemistry and Molecular Neurobiology$b[electronic resource] $eNeuroimmunology /$fedited by Armen Galoyan, Hugo Besedovsky 205 $a3rd ed. 2008. 210 1$aNew York, NY :$cSpringer US :$cImprint: Springer,$d2008. 215 $a1 online resource (XIII, 495 p. eReference.) 225 1 $aSpringer reference 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-387-30358-8 320 $aIncludes bibliographical references and index. 327 $aBRAIN CYTOKINES AS INTEGRATORS OF THE IMMUNE-NEUROENDOCRINE NETWORK ? H. O. Besedovsky and A. del Rey -- NEUROPEPTIDES IN THE IMMUNE SYSTEM: MEDIATORS OF STRESS AND INFLAMMATION ? D.S. Jessop -- EFFECTS OF THE IMMUNE SYSTEM ON BRAIN NEUROCHEMISTRY ? A. J. Dunn -- AGE-RELATED ALTERATIONS IN AUTONOMIC NERVOUS SYSTEM INNERVATION OF LYMPHOID TISSUE ? D. L. Bellinger, C. L. Lubahn, A. B. Millar, J. L. Carter, S. Vyas, S. D. Perez, and D. Lorton -- DRUGS THAT TARGET SYMPATHETIC-IMMUNE PATHWAYS FOR TREATMENT OF AUTOIMMUNE DISEASES ? D. Lorton, C. Lubahn, and D. Bellinger -- NEURO-IMMUNE ASSOCIATIVE LEARNING ? M.-B. Niemi, G. Pacheco-López, H. Engler, C. Riether, R. Doenlen, and M. Schedlowski -- THE BRAIN IMMUNE SYSTEM: CHEMISTRY AND BIOLOGY OF SIGNAL MOLECULES ? A. Galoyan -- THE DIALECT OF IMMUNE SYSTEM IN THE CNS: THE NERVOUS TISSUE AS IMMUNE COMPARTMENT FOR T CELLS AND DENDRITIC CELLS ? Z. Fabry, E. Reinke, A. Zozulya, M. Sandor, and I. Bechmann -- IMMUNOPROTEASOME ACTIVITY IN THE NERVOUS SYSTEM ? M. T. Rinaudo and M. Piccinini -- REGULATION OF THE INFLAMMATORY RESPONSE IN BRAIN ? W. Stenzel and G. Alber -- EVOLUTIONARY ORIGINS OF THE BRAIN'S IMMUNE PRIVILEGE. IMPLICATIONS FOR NOVEL THERAPEUTIC APPROACHES: GENE THERAPY ? P. R. Lowenstein, K. Kroeger, C. Barcia, J. Zirger, D. Larocque, and M. G. Castro -- ADENOSINE: AN ENDOGENOUS REGULATOR OF THE BRAIN IMMUNE SYSTEM ? G. Haskó and E. S. Vizi -- NEUROIMMUNE CROSS TALK ? G. Juhász -- ROLE OF GLIA IN CNS INFLAMMATION ? S. Pawate and N. R. Bhat -- AUTOIMMUNE PROCESSES IN THE CENTRAL NERVOUS SYSTEM ? C. J. Welsh and C. R. Young -- EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ? B. Gran, K. O?Brian, D. Fitzgerald, and A. Rostami -- IMMUNOLOGICAL ASPECTS OF CENTRAL NERVOUS SYSTEM DEMYELINATION ? S. Pawate and S. Sriram -- THE INFLAMMATORY COMPONENT OF NEURODEGENERATIVE DISEASES ? C. C. Ferrari and F. J. Pitossi -- MECHANISMS OF INFLAMMATION IN HIV-ASSOCIATED DEMENTIA ? B. Giunta, F. Fernandez, and J. Tan -- ROLE OF POLY(ADP-RIBOSE) POLYMERASE IN BRAIN INFLAMMATION AND NEUROINJURY ? G. S. Scott, K. Komjáti, V. C. Besson, and C. Szabó -- SCHIZOPHRENIA AND IMMUNE RESPONSES ? F. Gaughran, J. Welch. 330 $aThis volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain. 410 0$aSpringer reference. 606 $aNeurosciences 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aNeurosciences. 615 14$aNeurosciences. 676 $a616.80479 702 $aGaloyan$b Armen$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBesedovsky$b Hugo$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483213003321 996 $aHandbook of Neurochemistry and Molecular Neurobiology$92844863 997 $aUNINA