LEADER 03089nam 2200469 450 001 9910483169003321 005 20210323123203.0 010 $a3-030-66306-X 024 7 $a10.1007/978-3-030-66306-3 035 $a(CKB)4100000011704500 035 $a(DE-He213)978-3-030-66306-3 035 $a(MiAaPQ)EBC6452025 035 $a(PPN)253250277 035 $a(EXLCZ)994100000011704500 100 $a20210323d2021 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBotulinum toxin therapy /$fScott M. Whitcup, Mark Hallett, editors 205 $a1st ed. 2021. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$dİ2021 215 $a1 online resource (VIII, 289 p.) 225 1 $aHandbook of experimental pharmacology ;$vVolume 263 311 $a3-030-66305-1 327 $aPart 1. Basic Science -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- Botulinum Neurotoxins: Mechanism of Action -- Manufacturing and Clinical Formulations of Botulinum Neurotoxins -- Novel Native and Engineered Botulinum Neurotoxins -- Part 2. Clinical Practice -- Clinical Pharmacology of Botulinum Toxin Drugs -- The Use of Botulinum Toxin for Treatment of the Dystonias -- The Use of Botulinum Toxin for Treatment of Spasticity -- Use of Botulinum Toxin in Ophthalmology -- Hyperhidrosis and Aesthetics -- Use of Botulinum Toxin in Genitourinary System -- Gastrointestinal Uses of Botulinum Toxin -- The Use of Botulinum Toxin in the Management of Headache Disorders -- Botulinum Toxin and Pain -- The Use of Botulinum Toxin for Treatment of Depression. 330 $aIn a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use and the development of novel therapeutic toxins for the future. Part 2 reviews the use of botulinum toxins in clinical practice. It discusses the clinical pharmacology of botulinum toxin drugs and their use in a wide variety of clinical conditions including headache, spasticity, pain, disorders of the genitourinary and gastrointestinal tract, strabismus, and medical aesthetics. 410 0$aHandbook of experimental pharmacology ;$vVolume 263. 606 $aPsychopharmacology 615 0$aPsychopharmacology. 676 $a615.78 702 $aWhitcup$b Scott M. 702 $aHallett$b Mark 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483169003321 996 $aBotulinum toxin therapy$91829245 997 $aUNINA