LEADER 04766nam 22008415 450 001 9910483148503321 005 20251226195056.0 024 7 $a10.1007/b105490 035 $a(CKB)1000000000212699 035 $a(SSID)ssj0000319791 035 $a(PQKBManifestationID)11227258 035 $a(PQKBTitleCode)TC0000319791 035 $a(PQKBWorkID)10338581 035 $a(PQKB)11290976 035 $a(DE-He213)978-3-540-32280-1 035 $a(MiAaPQ)EBC3067989 035 $a(PPN)123091608 035 $a(BIP)11530560 035 $a(EXLCZ)991000000000212699 100 $a20100701d2005 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aRegulatory Genomics $eRECOMB 2004 International Workshop, RRG 2004, San Diego, CA, USA, March 26-27, 2004, Revised Selected Papers /$fedited by Eleazar Eskin, Chris Workman 205 $a1st ed. 2005. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2005. 215 $a1 online resource (VIII, 116 p.) 225 1 $aLecture Notes in Bioinformatics,$x2366-6331 ;$v3318 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$aPrinted edition: 9783540244561 320 $aIncludes bibliographical references and index. 327 $aPredicting Genetic Regulatory Response Using Classification: Yeast Stress Response -- Detecting Functional Modules of Transcription Factor Binding Sites in the Human Genome -- Fishing for Proteins in the Pacific Northwest -- PhyloGibbs: A Gibbs Sampler Incorporating Phylogenetic Information -- Application of Kernel Method to Reveal Subtypes of TF Binding Motifs -- Learning Regulatory Network Models that Represent Regulator States and Roles -- Using Expression Data to Discover RNA and DNA Regulatory Sequence Motifs -- Parameter Landscape Analysis for Common Motif Discovery Programs -- Inferring Cis-region Hierarchies from Patterns in Time-Course Gene Expression Data -- Modeling and Analysis of Heterogeneous Regulation in Biological Networks. 330 $aResearch in the ?eld of gene regulation is evolving rapidly in an ever-changing s- enti'c environment. Microarray techniques and comparative genomics have enabled more comprehensive studies of regulatory genomics and are proving to be powerful tools of discovery. The application of chromatin immunoprecipitation and microarrays (chIP-on-chip) to directly study the genomic binding locations of transcription factors has enabled more comprehensive modeling of regulatory networks. In addition, c- plete genome sequences and the comparison of numerous related species has dem- strated that conservation in non-coding DNA sequences often provides evidence for cis-regulatory binding sites. That said, much is still to be learned about the regulatory networks of these sequenced genomes. Systematic methods to decipher the regulatory mechanism are also crucial for c- roboratingthese regulatorynetworks.Thecoreof thesemethodsarethe motifdiscovery algorithms that can help predict cis-regulatory elements. These DNA-motif discovery programsarebecomingmoresophisticatedandare beginningto leverageevidencefrom comparative genomics (phylogenetic footprinting) and chIP-on-chip studies. How to use these new sources of evidence is an active area of research. 410 0$aLecture Notes in Bioinformatics,$x2366-6331 ;$v3318 606 $aBiochemistry 606 $aAlgorithms 606 $aComputer science$xMathematics 606 $aDiscrete mathematics 606 $aArtificial intelligence$xData processing 606 $aDatabase management 606 $aBioinformatics 606 $aBiochemistry 606 $aAlgorithms 606 $aDiscrete Mathematics in Computer Science 606 $aData Science 606 $aDatabase Management 606 $aBioinformatics 615 0$aBiochemistry. 615 0$aAlgorithms. 615 0$aComputer science$xMathematics. 615 0$aDiscrete mathematics. 615 0$aArtificial intelligence$xData processing. 615 0$aDatabase management. 615 0$aBioinformatics. 615 14$aBiochemistry. 615 24$aAlgorithms. 615 24$aDiscrete Mathematics in Computer Science. 615 24$aData Science. 615 24$aDatabase Management. 615 24$aBioinformatics. 676 $a572 701 $aEskin$b Eleazar$01652094 701 $aWorkman$b Chris$01763076 712 12$aInternational Conference on Research in Computational Molecular Biology$d(8th :$f2004 :$eSan Diego, Calif.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910483148503321 996 $aRegulatory genomics$94203333 997 $aUNINA