LEADER 03032nam 2200481 450 001 9910482992303321 005 20210326134044.0 010 $a3-030-63817-0 024 7 $a10.1007/978-3-030-63817-7 035 $a(CKB)4100000011743109 035 $a(DE-He213)978-3-030-63817-7 035 $a(MiAaPQ)EBC6467021 035 $a(PPN)253254094 035 $a(EXLCZ)994100000011743109 100 $a20210326d2021 uy 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCollagen biografts for tunable drug delivery /$fRucha Joshi 205 $a1st ed. 2021. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$dİ2021 215 $a1 online resource (XII, 107 p. 41 illus., 30 illus. in color.) 225 1 $aSpringerBriefs in Applied Sciences and Technology 311 $a3-030-63816-2 327 $aIntroduction -- Creating Tunable Collagen Matrices - An Approach Inspired by In-Vivo Collagen Synthesis and Self-Assembly -- Application of Collagen Fibril Biografts for Enhancing Local Vascularization in an In-Vivo Chick Chorioallantoic Membrane (CAM) Model -- Appendix A: Type I Collagen Based Drug Delivery Formats -- Appendix B: State-of-the-Art Methods of Tuning Collagen Based Molecular Release. 330 $aThis book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen ; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery. 410 0$aSpringerBriefs in applied sciences and technology. 606 $aCollagen$xTherapeutic use 606 $aBiomedical materials$xTherapeutic use 615 0$aCollagen$xTherapeutic use. 615 0$aBiomedical materials$xTherapeutic use. 676 $a610.284 700 $aJos?i?$b R?ca?$01226370 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910482992303321 996 $aCollagen biografts for tunable drug delivery$92847549 997 $aUNINA