LEADER 03273nam 2200565 450 001 9910482959303321 005 20220701113009.0 010 $a3-030-72599-5 024 7 $a10.1007/978-3-030-72599-0 035 $a(CKB)4100000011918710 035 $a(DE-He213)978-3-030-72599-0 035 $a(MiAaPQ)EBC6611777 035 $a(Au-PeEL)EBL6611777 035 $a(OCoLC)1251442316 035 $a(PPN)255888147 035 $a(EXLCZ)994100000011918710 100 $a20220120d2021 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAntibodies for treating cancer $ebasics, development, and applications /$fMelvyn Little 205 $a1st ed. 2021. 210 1$aCham, Switzerland :$cSpringer,$d[2021] 210 4$d©2021 215 $a1 online resource (XI, 151 p. 34 illus. in color.) 311 $a3-030-72598-7 327 $a1 Life-saving antibodies ? history of immunization -- 2 Current approaches for immunising against cancer -- 3 Function and Structure of antibodies -- 4 Of mice and men - production of therapeutic antibodies -- 5 Novel modular antibodies -- 6 Antibodies as ?Magic Bullets? -- 7 Mediation of tumor cell destruction -- 8 Engagement of immune killer cells -- 9 Approved antibodies for cancer therapy -- 10 Bringing therapeutic antibodies on the market -- 11 Future developments ? outlook. 330 $aThis book presents a compact overview of the history, evolution and fascinating novel applications of antibodies for the treatment of cancer, leading the reader step by step to the latest advances. Interesting anecdotes, together with self-explanatory and clearly structured figures with a humorous touch, facilitate the reader?s understanding of this complex topic. Clinical cases round out the book, making it a valuable aid for professionals in their everyday practice. The growing importance of the topics covered here was highlighted by the joint award of the 2018 Nobel Prize in Chemistry to Frances H. Arnold (directed evolution of enzymes), George P. Smith (phage display of peptides) and Sir Gregory P. Winter (phage display of antibodies). Furthermore, the 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation. Many of the antibodies that are now being brought to market target precisely these immune checkpoint modulators. The book addresses a broad readership, ranging from professionals and experts in the field to residents and medical students. 606 $aAntineoplastic antibiotics 606 $aHealth 606 $aImmunoglobulines$2thub 606 $aImmunoterąpia$2thub 606 $aCąncer$2thub 608 $aLlibres electrņnics$2thub 615 0$aAntineoplastic antibiotics. 615 0$aHealth. 615 7$aImmunoglobulines 615 7$aImmunoterąpia 615 7$aCąncer 676 $a616.99406 700 $aLittle$b Melvyn$f1945-$01075029 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910482959303321 996 $aAntibodies for treating cancer$92583281 997 $aUNINA