LEADER 05337nam 2200661Ia 450 001 9910455572103321 005 20200520144314.0 010 $a1-908978-64-3 010 $a1-282-75980-9 010 $a9786612759802 010 $a1-84816-295-2 035 $a(CKB)2490000000001722 035 $a(EBL)1681672 035 $a(OCoLC)729020326 035 $a(SSID)ssj0000425148 035 $a(PQKBManifestationID)11290950 035 $a(PQKBTitleCode)TC0000425148 035 $a(PQKBWorkID)10476595 035 $a(PQKB)11034952 035 $a(MiAaPQ)EBC1681672 035 $a(WSP)00000610 035 $a(Au-PeEL)EBL1681672 035 $a(CaPaEBR)ebr10422286 035 $a(CaONFJC)MIL275980 035 $a(EXLCZ)992490000000001722 100 $a20081119d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPerspectives on vasopressin$b[electronic resource] /$feditor, John Francis Laycock 210 $aLondon $cImperial College Press$dc2010 215 $a1 online resource (357 p.) 300 $aDescription based upon print version of record. 311 $a1-84816-294-4 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; Chapter 1. Introduction to Vasopressin (John Laycock); 1. Brief Historical Perspective; 2. General Development, Anatomy and Structure of the Neurohypophysial System; 3. Synthesis, Storage and Release of Neurohypophysial Hormones; 4. Vasopressin Assays; 5. Physiological Actions; 6. Receptors and Mechanisms of Action; 7. Circulation and Metabolism; 8. Control of Release of Vasopressin; 9. Clinical Aspects of Vasopressin; 10. Conclusion; Bibliography; Chapter 2. Comparative and Evolutionary Aspects of Vasopressin (Jacques Hanoune); 1. Introduction 327 $a2. Evolutionary Aspects of the Vasopressin Family3. Evolutionary Aspects of the Vasopressin Receptor Family; 4. Evolutionary Aspects of the Aquaporin Family; 5. Conclusion; Bibliography; Chapter 3. The Neurohypophysial System: Synthesis and Metabolism of Vasopressin (Jacques Hanoune); 1. Developmental Aspects of the Endocrine Hypothalamus; 2. Biosynthesis; a) Gene structure; b) Processing of the mature peptide; 3. Control of Vasopressin Secretion; a) Control by extracellular osmolality and volaemia; b) Additional factors ; 4. Extra-hypothalamic Expression of Vasopressin; a) Adrenal medulla 327 $ab) Testisc) Blood vessels and heart; d) Other organs; 5. Peripheral Degradation and Metabolic Clearance; Bibliography; Chapter 4. Vasopressin Receptors, the Signalling Cascade and Mechanisms of Action (Jacques Hanoune); 1. Introduction: A Short Historical Survey of Vasopressin Receptors; 2. Pharmacological Characterization of the Vasopressin Receptors; 3. Biochemical Characterization of the Vasopressin Receptors; 4. Tissue Expression; a) V1a receptor; b) V1b (V3) receptor; c) V2 receptor; 5. Vasopressin Receptors and G Proteins: An Overview; 6. Structure of the Vasopressin Receptors 327 $aa) General featuresb) Modelling of vasopressin receptors; 7. Structural Basis of the Receptor-Ligand Interaction; a) Binding of agonists; b) Binding of antagonists; 8. Domains Responsible for G Protein-Coupling Selectivity; 9. Dimerization of Receptors; 10. Signalling Pathways; a) The heterotrimeric G protein; b) The cyclic AMP pathway; c) The calcium/phosphatidyl inositol pathway; d) The V2 receptor pathway; e) The V1a receptor pathway; f ) The V1b receptor pathway; g) The proteomic approach; 11. Pre- and Post-transcriptional Regulation of Vasopressin Receptor Expression 327 $a12. Downregulation of Vasopressin Receptors: Desensitization and Internalization13. Are There Other Vasopressin Receptors?; Bibliography; Chapter 5. Pharmacology of the Vasopressin Receptors (Jacques Hanoune); 1. Introduction; 2. Radio-labelled Ligands; 3. Pharmacology of the Vasopressin V1a Receptor; 4. Pharmacology of the Vasopressin V1b Receptor; 5. Pharmacology of the Vasopressin V2 Receptor; 6. Mixed Vasopressin V1a/V2 Receptor Antagonists; 7. Inter-species and Inter-organ Variability; 8. Conclusion; Bibliography; Chapter 6. Vasopressin and Its Renal Effects (John Laycock) 327 $a1. Introduction 330 $a Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours. This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotr 606 $aVasopressin 606 $aVasopressin$xPhysiological effect 608 $aElectronic books. 615 0$aVasopressin. 615 0$aVasopressin$xPhysiological effect. 676 $a612.492 701 $aLaycock$b John F$0954157 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910455572103321 996 $aPerspectives on vasopressin$92158002 997 $aUNINA LEADER 01067nam 2200253la 450 001 9910482382603321 005 20221108070053.0 035 $a(UK-CbPIL)2090336392 035 $a(CKB)5500000000091346 035 $a(EXLCZ)995500000000091346 100 $a20210618d1599 uy | 101 0 $adut 135 $aurcn||||a|bb| 200 10$aVoorstel ende redenen die de coninck van Vranckr?ck den gedeputeerden vanden Parlemente heeft voorghehouden op den 7. januarij 1599. Translated from the French into Dutch$b[electronic resource] 210 $aAmsterdam $cHerman Allertsz Koster$d1599 215 $aOnline resource (8°) 300 $aReproduction of original in Koninklijke Bibliotheek, Nationale bibliotheek van Nederland. 700 $aAnon$0815482 801 0$bUk-CbPIL 801 1$bUk-CbPIL 906 $aBOOK 912 $a9910482382603321 996 $aVoorstel ende redenen die de coninck van Vranckr?ck den gedeputeerden vanden Parlemente heeft voorghehouden op den 7. januarij 1599. Translated from the French into Dutch$91932459 997 $aUNINA