LEADER 01860nam 2200529 450 001 9910480101503321 005 20170821175356.0 010 $a0-309-31271-X 035 $a(CKB)3710000000336165 035 $a(EBL)3379406 035 $a(SSID)ssj0001468602 035 $a(PQKBManifestationID)11902749 035 $a(PQKBTitleCode)TC0001468602 035 $a(PQKBWorkID)11536132 035 $a(PQKB)10154872 035 $a(MiAaPQ)EBC3379406 035 $a(EXLCZ)993710000000336165 100 $a20150121h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEnsuring patient access to affordable cancer drugs $eworkshop summary /$fSharyl J. Nass and Margie Patlak 210 1$aWashington, District of Columbia :$cThe National Academies Press,$d2014. 210 4$d©2014 215 $a1 online resource (74 p.) 300 $aDescription based upon print version of record. 311 $a0-309-31270-1 327 $a""FrontMatter""; ""Reviewers""; ""Acknowledgments""; ""Contents""; ""Boxes, Figures, and Table""; ""Acronyms""; ""Workshop Summary""; ""Appendix: Workshop Statement of Task and Agenda"" 606 $aHealth services accessibility$zUnited States 608 $aElectronic books. 615 0$aHealth services accessibility 676 $a362.1782 700 $aNass$b Sharyl J.$0857626 702 $aPatlak$b Margie 712 02$aNational Cancer Policy Forum. 712 02$aBoard on Health Care Services. 712 02$aInstitute of Medicine (U.S.) 712 12$aEnsuring Patient Access to Affordable Cancer Drugs (Workshop) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910480101503321 996 $aEnsuring patient access to affordable cancer drugs$91997908 997 $aUNINA LEADER 04263nam 22006615 450 001 9910409699503321 005 20250609112149.0 010 $a3-030-39267-8 024 7 $a10.1007/978-3-030-39267-3 035 $a(CKB)4100000011034444 035 $a(DE-He213)978-3-030-39267-3 035 $a(MiAaPQ)EBC6175305 035 $a(PPN)243761554 035 $a(MiAaPQ)EBC6175380 035 $a(EXLCZ)994100000011034444 100 $a20200413d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCorynebacterium glutamicum $eBiology and Biotechnology /$fedited by Masayuki Inui, Koichi Toyoda 205 $a2nd ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (VIII, 378 p. 74 illus., 34 illus. in color.) 225 1 $aMicrobiology Monographs,$x1862-5576 ;$v23 300 $aIncludes index. 311 08$a3-030-39266-X 327 $aPart I. Characteristics of Corynebacterium glutamicum -- Chromosome Organization and Cell Growth of Corynebacterium glutamicum -- Architecture and Biogenesis of the Cell Envelope of Corynebacterium glutamicum -- Respiratory Chain and Energy Metabolism of Corynebacterium glutamicum -- Part II. Regulation at Various Levels -- Sigma Factors of RNA Polymerase in Corynebacterium glutamicum -- Global Transcriptional Regulators Involved in Carbon, Nitrogen, Phosphorus, and Sulfur Metabolisms in Corynebacterium glutamicum -- Post-Translational Modifications in Corynebacterium glutamicum -- Part III. Amino Acids -- Recent Advances in Amino Acid Production -- Pathways at Work: Metabolic Flux Analysis of the Industrial Cell Factory Corynebacterium glutamicum -- Amino Acid Exporters in Corynebacterium glutamicum -- Part IV. Metabolic Design for a Wide Variety of Products -- Metabolic Engineering in Corynebacterium glutamicum -- Aromatic Compound Catabolism in Corynebacterium glutamicum -- Aromatic Compound Production by Corynebacterium glutamicum. 330 $aThis updated second edition covers the molecular biology, genome engineering tools and comprehensive analysis techniques for Corynebacterium glutamicum. Aside from modern omics-based approaches, the authors also focus on cell physiology, including cell division, central carbon metabolic pathways, and the respiratory chain. Readers will learn how primary mechanisms like energy metabolism can be applied in processes like biorefinery. Newly added topics include cell envelope structures and aromatic compound metabolism in C. glutamicum. These chapters will be particularly useful for those interested in the microbial production of commodity chemicals, fuels, and proteins. Corynebacteriacea are already some of the most important industrial microorganisms. Understanding the cell physiology of C. glutamicum will help manufacturers to increase their product range and productivity through efficient metabolic engineering. 410 0$aMicrobiology Monographs,$x1862-5576 ;$v23 606 $aMicrobiology 606 $aBiochemistry 606 $aMicrobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L23004 606 $aApplied Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/C12010 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aBacteris$2thub 606 $aEnginyeria genètica$2thub 606 $aBiologia molecular$2thub 608 $aLlibres electrònics$2thub 615 0$aMicrobiology. 615 0$aBiochemistry. 615 14$aMicrobiology. 615 24$aApplied Microbiology. 615 24$aBiochemistry, general. 615 7$aBacteris. 615 7$aEnginyeria genètica. 615 7$aBiologia molecular 676 $a579.373 702 $aInui$b Masayuki$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aToyoda$b Koichi$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910409699503321 996 $aCorynebacterium glutamicum$91944960 997 $aUNINA