LEADER 02642nam 2200349 450 001 9910476883203321 005 20230516144918.0 035 $a(CKB)5470000000567125 035 $a(NjHacI)995470000000567125 035 $a(EXLCZ)995470000000567125 100 $a20230516d2021 uy 0 101 0 $afin 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLaatokka $eSuurja?rven kiehtova rantahistoria /$fMaria La?hteenma?ki 210 1$aHelsinki :$cFinnish Literature Society / SKS,$d2021. 215 $a1 online resource (315 pages) 311 $a951-858-396-X 330 $aFor the first time worldwide, this collection brings together analyses of the last two centuries of historical change around the shores and drainage basin of Lake Ladoga, Europe's largest lake. The main focus of the narrative is the Northern Ladoga region, which was a Finnish administrative area between 1812 and 1944. After the Second World War, the entire shoreline of Lake Ladoga was incorporated into the northeast part of Russia's border region, the Autonomous Republic of Karelia and the Leningrad Province. The main theme uniting this collection is how the relationship between humans and nature is shaped by industrialization and modernization in society. Other key issues include protecting nature and perspectives on particular places and times, which are reflected in the methodological and thematic choices made in this volume. The research framework set by the editor, Professor Maria La?hteenma?ki, is the new lakefront history (Finn. uusi rantahistoria), focusing on approaches to environmental, economic and sensory history of lakes. To draw broad conclusions, on the one hand, the multilevel changes on the lakefront cannot be understood without knowledge of the history of the wider drainage basin, and awareness of the geopolitics of the region and the climate changes. On the other hand, the human relationship to natural waters has changed significantly in 200 years. Thinking in terms of economic benefit has gradually given way to principles of sustainable development. Lake Ladoga is also being redefined from a spatial perspective, as nationalist ownership of the region is coupled with global concern about the state of Europe's largest lake. 517 $aLaatokka 606 $aShore protection 615 0$aShore protection. 676 $a627.58 700 $aLa?hteenma?ki$b Maria$0690445 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910476883203321 996 $aLaatokka$93363402 997 $aUNINA LEADER 04829nam 22007335 450 001 9911018746303321 005 20250725130238.0 010 $a3-031-99374-8 024 7 $a10.1007/978-3-031-99374-9 035 $a(MiAaPQ)EBC32235422 035 $a(Au-PeEL)EBL32235422 035 $a(CKB)39713184000041 035 $a(DE-He213)978-3-031-99374-9 035 $a(OCoLC)1531319686 035 $a(EXLCZ)9939713184000041 100 $a20250725d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCancer Immunology and Genetics: An Interdisciplinary Approach /$fedited by Nima Rezaei 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (1222 pages) 225 1 $aInterdisciplinary Cancer Research,$x2731-457X ;$v23 311 08$a3-031-99373-X 327 $aThymic Stromal Lymphopoietin and Malignancies -- Immunogenic Cancer Cell Death -- Epigenetics in Cancer Biology -- Microenvironment of Normal Looking Tissues Adjacent to Cancer: Matters Arising -- The Paradoxical Role of Immune Response in Cancer Microenvironment -- T Cells and Their Roles in Tumor Microenvironments -- Role of Regulatory Immune Cells in Tumour Microenvironment (TME) -- Exploring the Metabolic Reprogramming of Immune Cells in Tumor Microenvironments -- Innate Lymphoid Cells in Cancer Immunobiology and Immunotherapy -- Tumor-Associated Macrophages and Their Role in Cancer Progression and Treatment Strategies -- Tumor-associated Macrophages in Colorectal Cancer -- Impact of Siglec-Sialic Acid Axis on the Cancer Immune Response -- Mechanisms on Telomere Maintenance in Cancer Cells -- Classification of SNPs, Tips from the Basic Knowledge to the Clinical Outcomes -- The Potential Role of HLA-G on Cancer -- Two Sides of the Same Coin: Genes Involvement in Neurodegeneration and Cancer -- MicroRNA: Exploring Their Multifaceted Role in Cancer -- Role of miRNAs in cancer: Main Therapeutic, Diagnostic, and Oncogenic Features -- LncRNA: Secret Regulators of Cancer Metabolism -- Structure and Function of The H19 Long Non-Coding RNA in Cancer -- Genome Editing: Current Approaches and the Road Ahead in Cancer Research and Therapeutics -- Targeting Epigenetic Readers Using Small Molecule Binders and PROTAC Degraders -- Pharmacogenomics of Cancer Chemotherapy: Transporter Polymorphisms and Drug Response -- Genetic Variants Associated with Morphine Treatment in Cancer. 330 $aThe ?Cancer Immunology and Genetics: An Interdisciplinary Approach? is the twenty third volume of the ?Interdisciplinary Cancer Research? series, publishes comprehensive volume on cancer immunology and genetics. The volume starts with a chapter on thymic stromal lymphopoietin and cancers, followed by other chapters on immunogenic cancer cell death and epigenetics. Tumor microenvironments, innate lymphoid cells, and tumor-associated macrophages are explained in subsequent chapters. Other chapters focus on telomere maintenance in cancer cells, single nucleotide polymorphisms, Human leukocyte antigen, long non-coding RNA, and microRNA as oncogenic features as well as diagnostic and therapeutic approaches. Finally, genome editing, targeting epigenetic readers, and pharmacogenomics of cancer chemotherapy are discussed in the last chapters. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for those who wish to have an update on cancer immunology and genetics. 410 0$aInterdisciplinary Cancer Research,$x2731-457X ;$v23 606 $aCancer 606 $aCancer$xTreatment 606 $aOncology 606 $aImmunotherapy 606 $aTumors$xImmunological aspects 606 $aNanomedicine 606 $aCancer Biology 606 $aCancer Therapy 606 $aOncology 606 $aImmunotherapy 606 $aTumour Immunology 606 $aCancer Nanotechnology 615 0$aCancer. 615 0$aCancer$xTreatment. 615 0$aOncology. 615 0$aImmunotherapy. 615 0$aTumors$xImmunological aspects. 615 0$aNanomedicine. 615 14$aCancer Biology. 615 24$aCancer Therapy. 615 24$aOncology. 615 24$aImmunotherapy. 615 24$aTumour Immunology. 615 24$aCancer Nanotechnology. 676 $a571.978 676 $a616.994 700 $aRezaei$b Nima$0913363 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911018746303321 996 $aCancer Immunology and Genetics: An Interdisciplinary Approach$94414834 997 $aUNINA