LEADER 03075nam 2200541 450 001 9910467334503321 005 20200520144314.0 010 $a3-11-051504-0 010 $a3-11-051575-X 024 7 $a10.1515/9783110515756 035 $a(CKB)4100000002964631 035 $a(MiAaPQ)EBC5157812 035 $a(DE-B1597)472726 035 $a(OCoLC)1025395624 035 $a(DE-B1597)9783110515756 035 $a(Au-PeEL)EBL5157812 035 $a(CaPaEBR)ebr11566804 035 $a(EXLCZ)994100000002964631 100 $a20180621d2018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMacrolides $eproperties, synthesis and applications /$fBiljana Arsic [and five others] 210 1$aBerlin ;$aBoston :$cDe Gruyter,$d[2018] 215 $a1 online resource (112 pages) 311 $a3-11-051502-4 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tPreface -- $tContents -- $t1. The macrolide antibiotics and their semi-synthetic derivatives / $rArsic, Biljana / Barber, Jill / Novak, Predrag -- $t2. The semisynthetic routes towards better macrolide antibiotics / $rKragol, Goran -- $t3. Interactions of macrolides with their biological targets / $rNovak, Predrag -- $t4. Hybrids of macrolides and nucleobases or nucleosides: synthetic strategies and biological results / $rSodano, Federica / Rimoli, Maria Grazia -- $tIndex 330 $aMacrolide antibiotics represent a class of natural macrocyclic products, one of the most clinically important antibiotics. Unfortunately, the production and development of new macrolide antibiotics are not represented enough in the pharmaceutical industry today. The intention of the book is therefore not only to be a teaching tool for students and experts, but also to draw the attention of the general public to this extremely useful, cheap and relatively unharmful effective anti-macrobials, and potential anti-malarials. The authors introduce the different classes of macrolides and their derivatives, principles of their biological activity, their structure and interactions with biological targets as well as synthetic methods to produce new macrolide antibiotics of similar or improved properties. Special emphasis was put on conjugates of macrolides with nucleobases or nucleosides with numerous applications; among them the most important remains the attempt to overcome bacterial resistance. 606 $aAntibacterial agents 606 $aMacrolide antibiotics 606 $aSCIENCE / Chemistry / Organic$2bisacsh 608 $aElectronic books. 615 0$aAntibacterial agents. 615 0$aMacrolide antibiotics. 615 7$aSCIENCE / Chemistry / Organic. 676 $a615.7922 700 $aArsic$b Biljana, $01035874 702 $aArsic$b Biljana$f1980- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910467334503321 996 $aMacrolides$92455810 997 $aUNINA LEADER 02443nam 2200685Ia 450 001 9910461986203321 005 20211105231628.0 010 $a3-11-088218-3 024 7 $a10.1515/9783110882186 035 $a(CKB)2670000000250971 035 $a(EBL)3041984 035 $a(SSID)ssj0000780855 035 $a(PQKBManifestationID)11491832 035 $a(PQKBTitleCode)TC0000780855 035 $a(PQKBWorkID)10803167 035 $a(PQKB)11527386 035 $a(MiAaPQ)EBC3041984 035 $a(DE-B1597)54520 035 $a(OCoLC)979587025 035 $a(DE-B1597)9783110882186 035 $a(Au-PeEL)EBL3041984 035 $a(CaPaEBR)ebr10597877 035 $a(OCoLC)922944897 035 $a(EXLCZ)992670000000250971 100 $a19901212d1990 uy 0 101 0 $aeng 135 $aurnn#---|u||u 181 $ctxt 182 $cc 183 $acr 200 10$aGerman kinship terms, 750-1500$b[electronic resource] $edocumentation and analysis /$fWilliam Jervis Jones 205 $aReprint 2012 210 $aBerlin ;$aNew York $cW. de Gruyter$d1990 215 $a1 online resource (316 p.) 225 0 $aStudia Linguistica Germanica ;$v27 300 $aSummary in German. 311 0 $a3-11-012023-2 320 $aIncludes bibliographical references (p. [219]-272). 327 $tFront matter --$tPREFACE --$tCONTENTS --$tLIST OF DIAGRAMS --$t1. INTRODUCTION --$t2. A SYNCHRONIC VIEW --$t3. A CONTRASTIVE APPROACH --$t4. A DIACHRONIC VIEW --$t5. CONCLUSIONS --$t6. BIBLIOGRAPHY --$tSUMMARY --$tSUBJECT INDEX --$tBack matter 410 0$aStudia Linguistica demanica 606 $aGerman language$yOld High German, 750-1050$xLexicology 606 $aGerman language$yMiddle High German, 1050-1500$xLexicology 606 $aGerman language$yOld High German, 750-1050$xSemantics 606 $aGerman language$yMiddle High German, 1050-1500$xSemantics 606 $aKinship$vTerminology 608 $aElectronic books. 615 0$aGerman language$xLexicology. 615 0$aGerman language$xLexicology. 615 0$aGerman language$xSemantics. 615 0$aGerman language$xSemantics. 615 0$aKinship 676 $a437/.01 700 $aJones$b William Jervis$f1941-$0168358 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910461986203321 996 $aGerman kinship terms, 750-1500$91902735 997 $aUNINA