LEADER 02525nam 2200577 450 001 9910467016603321 005 20200125132828.0 010 $a2-8062-6440-5 035 $a(CKB)3790000000019291 035 $a(EBL)2104181 035 $a(MiAaPQ)EBC2104181 035 $a(PPN)233411143 035 $a(Au-PeEL)EBL2104181 035 $a(OCoLC)915311497 035 $a(EXLCZ)993790000000019291 100 $a20200125h20152015 uy 0 101 0 $afre 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aThomas Edison, le magicien de Menlo Park $ela vie lumineuse d'un inventeur insatiable /$fpar Benjamin Reyners ; Avec la collaboration de Christelle Klein-Scholz 210 1$aNamur, Belgium :$cLemaitre Publishing,$d[2015] 210 4$dİ2015 215 $a1 online resource (40 p.) 225 0 $aGrandes Inventions ;$vnume?ro 3 300 $aDescription based upon print version of record. 311 $a2-8062-6441-3 320 $aIncludes bibliographical references. 330 $a De?couvrez enfin tout ce qu'il faut savoir sur Thomas Edison et ses inventions en moins d'une heure !Inventeur de ge?nie, Thomas Edison est aussi l'un des plus prolifiques de tous les temps. Pourtant, rien ne laissait pre?sager un tel destin... Peu scolarise?, il est d'abord vendeur de journaux a? 12 ans, puis te?le?graphiste a? 15, avant de devenir l'un des meilleurs inge?nieurs de Wall Street a? seulement 22 ans. Il ne cesse de?s lors d'accumuler les succe?s. Dote? d'une curiosite? insatiable et passionne? depuis l'enfance par les expe?riences en tous genres, il cre?e coup sur coup les plus grandes inventio 410 0$aGrandes Inventions 606 $aInventors$zUnited States$vBiography 606 $aElectrical engineers$zUnited States$vBiography 606 $aTelephone$xHistory 606 $aBIOGRAPHY & AUTOBIOGRAPHY$xScience & Technology$2bisacsh 606 $aHISTORY$zUnited States$y20th Century$2bisacsh 608 $aElectronic books. 615 0$aInventors 615 0$aElectrical engineers 615 0$aTelephone$xHistory. 615 7$aBIOGRAPHY & AUTOBIOGRAPHY$xScience & Technology. 615 7$aHISTORY 676 $a621.3092 700 $aReyners$b Benjamin$0870635 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910467016603321 996 $aThomas Edison, le magicien de Menlo Park$91943598 997 $aUNINA LEADER 06367nam 2200769 450 001 9910153635703321 005 20230525195533.0 010 $a1-61504-733-6 024 7 $a10.4199/C00144ED1V01Y201610ISP067 035 $a(CKB)3710000000962284 035 $a(MiAaPQ)EBC4744545 035 $a(CaBNVSL)swl00406953 035 $a(OCoLC)964085804 035 $a(MOCL)201610ISP067 035 $a(EXLCZ)993710000000962284 100 $a20161206d2017 fy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aMolecular mechanisms of body water homeostasis /$fCarolyn M. Ecelbarger, Dharmendra Kumar Chaudhary, Hwal Lee, Swasti Tiwari 210 1$a[San Rafael, California] :$cMorgan & Claypool,$d2017. 215 $a1 online resource (112 pages) $ccolor illustrations 225 1 $aColloquium series on integrated systems physiology,$x2154-5626 ;$v# 68 300 $aPart of: Colloquium digital library of life sciences. 311 $a1-61504-732-8 320 $aIncludes bibliographical references (pages 75-97). 327 $a1. Water, water everywhere -- 1.1 Chapter overview -- 1.2 Body water composition -- 1.2.1 Changes in water homeostasis over the lifespan -- 1.2.2 Body water intake requirements -- 1.3 Measurement of total body water (TBW) -- 1.3.1 Body water compartmentalization -- 1.4 Dehydration -- 1.4.1 Exercise and water requirements -- 1.5 Environmental modulators of body water composition -- 1.5.1 High altitude -- 1.5.2 Extremes in temperature or humidity -- 1.5.3 Dietary alterations -- 327 $a2. The brain, AVP, and water balance -- 2.1 Chapter overview -- 2.2 The brain -- 2.3 Vasopressin and related neuropeptides -- 2.3.1 Regulation of vasopressin production and release -- 2.4 Vasopressin receptors -- 2.4.1 Receptor cloning -- 2.4.2 Receptor activation and signaling -- 2.4.3 Receptor localization -- 2.5 Vasopressin actions -- 2.5.1 Vasopressin and glomerular filtration rate (GFR) -- 2.5.2 Vasopressin and blood pressure control -- 2.5.2.1 AVPR2 are coupled to nitric oxide generation -- 2.5.2.2 Hypertension may correlate with urinary concentrating ability -- 327 $a3. Renal control of water reabsorption -- 3.1 Chapter overview -- 3.2 Blood filtration -- 3.3 The countercurrent multiplier mechanism -- 3.3.1 The Na-K-2Cl cotransporter (NKCC2) -- 3.3.2 Gradient in the inner medulla -- 3.4 The collecting duct -- 3.5 Urea transporters -- 3.6 Renal aquaporins -- 3.6.1 Aquaporin 1 -- 3.6.2 Aquaporin 2 -- 3.6.2.1 Short-term AQP2 regulation -- 3.6.2.2 Long-term AQP2 regulation -- 3.6.2.3 Regulators of AQP2 -- 3.6.3 Aquaporins 3 and 4 -- 3.6.4 Other aquaporins -- 327 $a4. Hyponatremia -- 4.1 Chapter overview -- 4.2 Causes and forms of hyponatremia -- 4.3 Hyponatremia and the brain -- 4.4 Hyponatremia and bone health -- 4.5 The syndrome of inappropriate antidiuretic hormone (SIADH) -- 4.5.1 Exercise-induced hyponatremia -- 4.6 Vasopressin escape and molecular mechanismS -- 4.7 Therapies/interventions -- 327 $a5. Diabetes insipidus -- 5.1 Chapter overview -- 5.2 Central diabetes insipidus (CDI) -- 5.3 Nephrogenic diabetes insipidus (NDI) -- 5.3.1 Mutations in the vasopressin V2 receptor -- 5.3.2 Mutations in AQP2 -- 5.4 Acquired NDI -- 5.5 Treatments for DI -- 327 $a6. Additional pathophysiological states associated with impaired water balance -- 6.1 Chapter overview -- 6.2 Heart failure -- 6.3 Hypertension -- 6.4 Cirrhosis of the liver -- 6.5 Compulsive water drinking -- 6.6 Burn injuries -- 6.7 Medications that alter fluid dynamics -- 6.7.1 Diuretics -- 6.7.2 Aquaretics -- 6.7.3 Peroxisome proliferator-activated receptor, subtype [gamma] (PPAR [gamma]) agonists -- 327 $aReferences -- Author biographies. 330 3 $aThis book discusses our intimate relationship with and dependence on water, how the body regulates its water levels, and various pathophysiological states associated with impairments in body water homeostasis. The human body consists of 70-80% water. Therefore, concise control of water homeostasis is essential to survival and involves coordination of several systems, but primarily the brain and kidney systems. Water requirements of the average healthy human range between 2-4 L/d, and a major portion of this can come from food sources. The major hormonal regulator of water balance is the anti-diuretic hormone, vasopressin. Vasopressin, a 9-amino acid peptide, is produced in the hypothalamus, stored in the posterior pituitary, and secreted when plasma osmolality rises. Vasopressin acts on the kidney to conserve water. The kidneys filter 180 L of blood per day, consisting of about 50-65% water, and reabsorb around 99% of this in the proximal tubule, distal tubule, and collecting duct, producing only 1-2 L of urine. The vasopressin-sensitive distal tubule and collecting duct are responsible for fine-tuning water reabsorption. Conditions exist, however, where urine cannot be concentrated effectively. This is known as diabetes insipidus and can lead to dehydration and failure to thrive. At the other extreme, hyponatremia (low serum sodium) is the inability to adequately dilute urine or get rid of free body water in excess of body needs, a serious and sometimes fatal condition. 410 0$aColloquium digital library of life sciences. 410 0$aColloquium series on integrated systems physiology ;$v# 68.$x2154-5626 606 $aOsmoregulation 606 $aWater in the body 606 $aOsmoregulation 606 $aBody Water 610 $awater homeostasis 610 $atotal body water 610 $akidney 610 $ahydration 610 $aaquaporin 610 $adiabetes insipidus 610 $ahyponatremia 610 $avasopressin 610 $aosmolality 615 0$aOsmoregulation. 615 0$aWater in the body. 615 2$aOsmoregulation. 615 20$aBody Water. 676 $a572.3 700 $aEcelbarger$b Carolyn M.$01264405 702 $aChaudhary$b Dharmendra Kumar 702 $aLee$b Hwal 702 $aTiwari$b Swasti 801 0$bCaBNVSL 801 1$bCaBNVSL 801 2$bCaBNVSL 906 $aBOOK 912 $a9910153635703321 996 $aMolecular mechanisms of body water homeostasis$92964335 997 $aUNINA