LEADER 05289nam 2200649Ia 450 001 9910465227903321 005 20200520144314.0 010 $a0-12-385472-5 035 $a(CKB)2560000000089216 035 $a(EBL)998897 035 $a(OCoLC)818109382 035 $a(SSID)ssj0000738871 035 $a(PQKBManifestationID)12327027 035 $a(PQKBTitleCode)TC0000738871 035 $a(PQKBWorkID)10673227 035 $a(PQKB)10139159 035 $a(MiAaPQ)EBC998897 035 $a(PPN)183333780 035 $a(Au-PeEL)EBL998897 035 $a(CaPaEBR)ebr10590766 035 $a(CaONFJC)MIL72891 035 $a(EXLCZ)992560000000089216 100 $a20060420d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPrinciples of clinical pharmacology$b[electronic resource] /$f[edited by] Arthur J. Atkinson, Jr. ... [et al.] 205 $a3rd ed. 210 $aLondon $cElsevier Academic Press$dc2012 215 $a1 online resource (649 p.) 300 $aDescription based upon print version of record. 311 $a0-12-385471-7 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Principles of Clinical Pharmacology; Copyright; Contents; Preface to the First Edition; Contributors; Chapter1 - Introduction to Clinical Pharmacology; BACKGROUND; PHARMACOKINETICS; REFERENCES; PARTI - PHARMACOKINETICS; Chapter2 - Clinical Pharmacokinetics; THE TARGET CONCENTRATION STRATEGY; CONCEPTS UNDERLYING CLINICAL PHARMACOKINETICS; MATHEMATICAL BASIS OF CLINICAL PHARMACOKINETICS; REFERENCES; STUDY PROBLEMS; Chapter3 - Compartmental Analysis of Drug Distribution; FIT-FOR-PURPOSE MODELING OF DRUG DISTRIBUTION; PHYSIOLOGICAL SIGNIFICANCE OF DRUG DISTRIBUTION VOLUMES 327 $aPHYSIOLOGICAL BASIS OF MULTICOMPARTMENTAL MODELS OF DRUG DISTRIBUTIONCLINICAL CONSEQUENCES OF DIFFERENT DRUG DISTRIBUTION PATTERNS; ESTIMATING MODEL PARAMETERS FROM EXPERIMENTAL DATA; REFERENCES; STUDY PROBLEMS; COMPUTER-BASED TUTORIALS; Chapter4 - Drug Absorption and Bioavailability; DRUG ABSORPTION; BIOAVAILABILITY; KINETICS OF DRUG ABSORPTION AFTER ORAL ADMINISTRATION; REFERENCES; STUDY PROBLEMS; COMPUTER-BASED TUTORIALS; Chapter5 - Effect of Renal Disease on Pharmacokinetics; DRUG DOSING IN PATIENTS WITH IMPAIRED RENAL FUNCTION; EFFECTS OF RENAL DISEASE ON RENAL DRUG EXCRETION MECHANISMS 327 $aEFFECTS OF IMPAIRED RENAL FUNCTION ON NON-RENAL METABOLISMEFFECTS OF RENAL DISEASE ON DRUG DISTRIBUTION; EFFECTS OF RENAL DISEASE ON DRUG ABSORPTION; REFERENCES; STUDY PROBLEM; Chapter6 - Pharmacokinetics in Patients Requiring Renal Replacement Therapy; KINETICS OF INTERMITTENT HEMODIALYSIS; KINETICS OF CONTINUOUS AND SUSTAINED RENAL REPLACEMENT THERAPY; CLINICAL CONSIDERATIONS; REFERENCES; COMPUTER-BASED TUTORIAL; Chapter7 - Effect of Liver Disease on Pharmacokinetics; HEPATIC ELIMINATION OF DRUGS; EFFECTS OF LIVER DISEASE ON PHARMACOKINETICS 327 $aUSE OF THERAPEUTIC DRUGS IN PATIENTS WITH LIVER DISEASEREFERENCES; Chapter8 - Non-Compartmental and Compartmental Approaches to Pharmacokinetic Data Analysis; INTRODUCTION; KINETICS, PHARMACOKINETICS AND PHARMACOKINETIC PARAMETERS; NON-COMPARTMENTAL ANALYSIS; COMPARTMENTAL ANALYSIS; NON-COMPARTMENTAL VS COMPARTMENTAL MODELS; CONCLUSION; REFERENCES; Chapter9 - Distributed Models of Drug Kinetics; INTRODUCTION; CENTRAL ISSUES; DRUG MODALITY I: DELIVERY ACROSS A PLANAR-TISSUE INTERFACE; DRUG MODALITY II: DELIVERY FROM A POINT SOURCE, DIRECT INTERSTITIAL INFUSION; SUMMARY; REFERENCES 327 $aChapter10 - Population PharmacokineticsINTRODUCTION; ANALYSIS OF PHARMACOKINETIC DATA; POPULATION PHARMACOKINETICS; MODEL APPLICATIONS; CONCLUSIONS; REFERENCES; PARTII - DRUG METABOLISM AND TRANSPORT; Chapter11 - Pathways of Drug Metabolism; INTRODUCTION; PHASE I BIOTRANSFORMATIONS; PHASE II BIOTRANSFORMATIONS (CONJUGATIONS); ADDITIONAL EFFECTS ON DRUG METABOLISM; REFERENCES; Chapter12 - Methods of Analysis of Drugs and Drug Metabolites; INTRODUCTION; CHOICE OF ANALYTICAL METHODOLOGY; PRINCIPLES OF ANALYSIS; EXAMPLES OF CURRENT ASSAY METHODS; ASSAY SELECTION; REFERENCES 327 $aChapter13 - Clinical Pharmacogenetics 330 $aPrinciples of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference cover 606 $aClinical pharmacology 606 $aPharmacology 608 $aElectronic books. 615 0$aClinical pharmacology. 615 0$aPharmacology. 676 $a615.1 676 $a615.58 701 $aAtkinson$b Arthur J$01034361 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910465227903321 996 $aPrinciples of clinical pharmacology$92453440 997 $aUNINA