LEADER 04210nam 2200625Ia 450 001 9910464968203321 005 20200520144314.0 010 $a1-283-59355-6 010 $a9786613906007 010 $a1-84816-904-3 035 $a(CKB)2560000000093119 035 $a(EBL)1019631 035 $a(OCoLC)811504384 035 $a(SSID)ssj0000771638 035 $a(PQKBManifestationID)12308481 035 $a(PQKBTitleCode)TC0000771638 035 $a(PQKBWorkID)10810874 035 $a(PQKB)10510921 035 $a(MiAaPQ)EBC1019631 035 $a(WSP)00002768 035 $a(Au-PeEL)EBL1019631 035 $a(CaPaEBR)ebr10596909 035 $a(CaONFJC)MIL390600 035 $a(EXLCZ)992560000000093119 100 $a20120924d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMalaria Genome Projects$b[electronic resource] $epromise, progress, and prospects /$fIrwin W. Sherman 210 $aLondon $cImperial College Press ;$aHackensack, NJ $cWorld Scientific$dc2012 215 $a1 online resource (389 p.) 300 $aDescription based upon print version of record. 311 $a1-84816-903-5 320 $aIncludes bibliographical references and index. 327 $aDedication; Contents; Preface; Chapter 1. Introduction; Plasmodium discovered; Plasmodium transmitted; Plasmodium in hiding; Chapter 2. Respice: Before the Genome Project; Chapter 3. The Nature of Plasmodium falciparum and its Genome; A home for the genome; Location, location, location; The malaria genome capers; Chapter 4. Chipping Away at the Genome; Turning "on," turning "off"; Evasion; Chapter 5. The Importance of Import; Chapter 6. Remodeling the Genome's Home; Chapter 7. Getting on the Inside; Chapter 8. The Great Escape; Chapter 9. The Neglected Malaria, Plasmodium vivax; Resistance 327 $aSecrets hidden in the genomeChapter 10. The Anopheles Genome and Transmission Control; Making mosquitoes immune; Making mosquitoes insecticide resistant; Replacement and/or reduction; Chapter 11. The Monkey's Tale; Chapter 12. A Not So Sweet Solution; Isoenzymes, the Achilles' heels of Plasmodium; Tackling the Krebs "cycle"; Chapter 13. To Search and Find; Rapid diagnostic tests; Nucleic acid-based tests; Loop-mediated isothermal amplification; Chapter 14. The Elusive Vaccines; Antigens before the genome; Two blood-stage vaccine candidates; The road to merozoite surface protein 327 $aThe road to apical membrane antigen 1A failed promise, SPf66; Transmission-blocking vaccines; The sporozoite vaccine revisited; Development of the pre-blood-stage vaccine, RTS, S; Back to the future; Learning from the liver; Vaccine approaches before sequencing the genome; Vaccine approaches after sequencing the genome; Chapter 15. New Medicines, Old Problems; The old problem of resistance; Chloro quine; Resistance to anti-folate drugs; Mefloquine and multidrug resistance; The fall of mefloquine; Atovaquone; Artemisia to artemisinins; Chapter 16. Prospice: Looking to the Future; References 327 $aIndex 330 $aThe year 2012 marks the tenth anniversary of the announcement of the genome sequence of the human malaria parasite Plasmodium falciparum and that of its mosquito vector Anopheles. The genome sequences were a result of the Plasmodium falciparum Genome Project.This book covers in detail the biology of malaria parasites and the mosquitoes that transmit the disease, how the Genome Projects came into being, the people who created them, and the cadre of scientists who are attempting to see the promise of the Projects realized. The promise was: a more complete understanding of the genes of the parasi 606 $aMalaria$xMolecular aspects 606 $aPlasmodium falciparum$xGenome mapping 608 $aElectronic books. 615 0$aMalaria$xMolecular aspects. 615 0$aPlasmodium falciparum$xGenome mapping. 676 $a616.9362 700 $aSherman$b Irwin W$0870972 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910464968203321 996 $aMalaria Genome Projects$92240155 997 $aUNINA