LEADER 06476nam 22007572 450 001 9910464935503321 005 20160309144021.0 010 $a1-139-89118-9 010 $a1-107-24941-4 010 $a1-107-24858-2 010 $a1-299-70751-3 010 $a1-107-25107-9 010 $a1-107-25024-2 010 $a1-139-22644-4 010 $a1-107-24775-6 035 $a(CKB)3460000000128925 035 $a(EBL)1357350 035 $a(OCoLC)857638186 035 $a(SSID)ssj0000886933 035 $a(PQKBManifestationID)11492542 035 $a(PQKBTitleCode)TC0000886933 035 $a(PQKBWorkID)10834667 035 $a(PQKB)10280407 035 $a(UkCbUP)CR9781139226448 035 $a(MiAaPQ)EBC1357350 035 $a(WaSeSS)IndRDA00019406 035 $a(Au-PeEL)EBL1357350 035 $a(CaPaEBR)ebr10718585 035 $a(CaONFJC)MIL502002 035 $a(EXLCZ)993460000000128925 100 $a20120105d2013|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAdvances in statistical bioinformatics $emodels and integrative inference for high-throughput data /$fedited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2013. 215 $a1 online resource (xv, 481 pages) $cdigital, PDF file(s) 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a1-107-02752-7 311 $a1-107-24154-5 320 $aIncludes bibliographical references and index. 327 $a""Contents""; ""List of Contributors""; ""Preface""; ""1 An Introduction to Next-Generation Biological Platforms""; ""Virginia Mohlere, Wenting Wang, and Ganiraju Manyam""; ""1.1 Introduction""; ""1.2 The Biology of Gene Silencing""; ""1.2.1 DNA Methylation""; ""1.2.2 RNA Interference""; ""1.3 High-Throughput Profiling""; ""1.3.1 Molecular Inversion Probe Arrays""; ""1.3.2 Array Comparative Genomic Hybridization (aCGH)""; ""1.3.3 Genome-Wide Association Studies""; ""1.3.4 Reverse-Phase Protein Array""; ""1.4 Next-Generation Sequencing""; ""1.4.1 Whole-Genome and Whole-Exome Sequencing"" 327 $a""1.4.2 ChIP-Seq""""1.4.3 RNA-Seq""; ""1.4.4 BS-seq""; ""1.5 NGS Data Management and Analysis""; ""1.6 Platform Integration""; ""Acknowledgments""; ""References""; ""References""; ""2 An Introduction to The Cancer Genome Atlas""; ""Bradley M. Broom and Rehan Akbani""; ""2.1 Introduction""; ""2.2 History and Goals of the TCGA Project""; ""2.3 Sample Collection and Processing""; ""2.3.1 Step 1: Tissue Collection""; ""2.3.2 Step 2: Quality Control and DNA/RNA Extraction""; ""2.3.3 Step 3: Molecular Profiling and Sequencing""; ""2.3.4 Step 4: Data Collection and Public Distribution"" 327 $a""2.3.5 Step 5: Data Analysis""""2.4 Data Processing, Storage, and Access""; ""2.4.1 TCGA Barcodes and UUIDs""; ""2.4.2 The Data Coordinating Center""; ""2.4.3 Data Access Matrix""; ""2.4.4 Bulk Download""; ""2.4.5 HTTP""; ""2.4.6 CGHub""; ""2.4.7 Sample and Data Relationship Format (SDRF) and Investigation Description Format (IDF) Files""; ""2.4.8 File Format""; ""2.4.9 Version""; ""2.5 Tools for Visualizing and Analyzing TCGA Data""; ""2.5.1 cBio Cancer Genomics Portal""; ""2.5.2 MBatch Portal""; ""2.5.3 Next-Generation Clustered Heat Maps""; ""2.5.4 Regulome Explorer"" 327 $a""2.5.5 Integrative Genome Viewer""""2.5.6 Cancer Genomics Browser""; ""2.6 Summary""; ""Acknowledgments""; ""References""; ""References""; ""3 DNA Variant Calling in Targeted Sequencing Data""; ""Wenyi Wang, Yu Fan, and Terence P. Speed""; ""3.1 Introduction""; ""3.2 Background""; ""3.2.1 Single-Nucleotide Variation""; ""3.2.2 Long Padlock Probes""; ""3.2.3 Array-Based Resequencing""; ""3.3 Sequence Robust Multiarray Analysis""; ""3.3.1 Quality Control""; ""3.3.2 Variant Calling""; ""3.4 Application of SRMA""; ""3.4.1 Candidate Gene Study for Mitochondrial Diseases"" 327 $a""3.4.2 Validation Results""""3.4.3 Biological Findings""; ""3.5 Conclusion""; ""Appendix""; ""References""; ""References""; ""4 Statistical Analysis of Mapped Reads from mRNA-Seq Data""; ""Ernest Turro and Alex Lewin""; ""4.1 Background""; ""4.1.1 RNA Biology""; ""4.1.2 RNA Technology""; ""4.2 Mapping and Assembly Strategies""; ""4.2.1 De Novo Assembly of the Transcriptome""; ""4.2.2 Genome-Guided Assembly of the Transcriptome""; ""4.2.3 Alignment to a Reference Transcriptome""; ""4.3 Modeling Expression Levels""; ""4.3.1 Poisson Model for Expression Quantification""; ""4.4 Normalization"" 327 $a""4.4.1 RPKM Normalization"" 330 $aProviding genome-informed personalized treatment is a goal of modern medicine. Identifying new translational targets in nucleic acid characterizations is an important step toward that goal. The information tsunami produced by such genome-scale investigations is stimulating parallel developments in statistical methodology and inference, analytical frameworks, and computational tools. Within the context of genomic medicine and with a strong focus on cancer research, this book describes the integration of high-throughput bioinformatics data from multiple platforms to inform our understanding of the functional consequences of genomic alterations. This includes rigorous and scalable methods for simultaneously handling diverse data types such as gene expression array, miRNA, copy number, methylation, and next-generation sequencing data. This material is written for statisticians who are interested in modeling and analyzing high-throughput data. Chapters by experts in the field offer a thorough introduction to the biological and technical principles behind multiplatform high-throughput experimentation. 606 $aBioinformatics$xStatistical methods 606 $aBiometry 606 $aGenetics$xTechnique 615 0$aBioinformatics$xStatistical methods. 615 0$aBiometry. 615 0$aGenetics$xTechnique. 676 $a572.80285 702 $aDo$b Kim-Anh$f1960- 702 $aQin$b Steven$f1972- 702 $aVannucci$b Marina$f1966- 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910464935503321 996 $aAdvances in statistical bioinformatics$91897046 997 $aUNINA LEADER 05264nam 2200649 450 001 9910815825803321 005 20230120014610.0 010 $a1-4832-9911-2 035 $a(CKB)3710000000199872 035 $a(EBL)1875354 035 $a(SSID)ssj0001266990 035 $a(PQKBManifestationID)12500937 035 $a(PQKBTitleCode)TC0001266990 035 $a(PQKBWorkID)11255172 035 $a(PQKB)11256561 035 $a(MiAaPQ)EBC1875354 035 $a(EXLCZ)993710000000199872 100 $a20141212h19801980 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aLanguage $esocial psychological perspectives : selected papers from the first International Conference on Social Psychology and Language held at the University of Bristol, England July 1979 /$fedited by Howard Giles, W. Peter Robinson and Philip Smith 205 $aFirst edition. 210 1$aOxford, England :$cPergamon Press,$d1980. 210 4$dİ1980 215 $a1 online resource (459 p.) 300 $aDescription based upon print version of record. 311 $a0-08-024696-6 320 $aIncludes bibliographical references at the end of each chapters and indexes. 327 $aFront Cover; Language: Social Psychological Perspectives; Copyright Page; Dedication; Table of Contents; Preface; Chapter 1.Social Psychological Perspectives on Language: Prologue; References; PART I:SYMPOSIUM: LANGUAGE ACQUISITION; Chapter 2.Language Acquisition: Introduction; References; Chapter 3. Contingent Queries: The First Chapter1; ABSTRACT; Key words; INTRODUCTION; METHOD; RESULTS AND DISCUSSION; CONCLUSIONS; REFERENCES; Chapter 4. The Acquisition of Social Speech Routines and Politeness Formulas1; ABSTRACT; Key words; TRICK OR TREAT; HI, THANKS AND GOODBYE; CONCLUSIONS; REFERENCES 327 $aChapter 5. Language and Play: A Comparative Analysis of Parental Initiatives1ABSTRACT; Key words; INTRODUCTION; METHOD; RESULTS; DISCUSSION; REFERENCES; Chapter 6.Mother-Child Conversation and Semantic Development; ABSTRACT; Key words; METHOD; RESULTS; DISCUSSION; REFERENCES; Chapter 7. Adjustments in Adult-Child Conversation: Some Effects of Interaction1; ABSTRACT; Key words; INTRODUCTION AND METHOD; RESULTS AND DISCUSSION; REFERENCES; PART II: SYMPOSIUM: CONVERSATION AND INTERPERSONAL INTERACTION; Chapter 8.Self-Consciousness and the Study of Interpersonal Interaction: Approaches and Issues 327 $aThought and Talk Excuse me, but have I been talking to myself?; Implications for the Symposium; Conclusion; REFERENCES; Chapter 9. The Language of Relationships: I. Description1; ABSTRACT; Key words; INTRODUCTION; CHARACTERISTICS OF INTERPERSONAL RELATIONSHIPS; A RELATIONAL ANALYSIS SYSTEM; METHOD; RESULTS; CONCLUSIONS AND IMPLICATIONS; SUMMARY; REFERENCES; Chapter 10.The Social Role of Slang; ABSTRACT; Key words; REFERENCES; Chapter 11.Consequences of Language Intensity and Compliance-Gaining Strategies in an Initial Heterosexual Encounter; ABSTRACT; Key words; INTRODUCTION AND RATIONALE 327 $aMETHODRESULTS; DISCUSSION; REFERENCES; Chapter 12.Accommodation in Children's Mixed-Age Social Interactions; ABSTRACT; Key Words; INTRODUCTION; RESEARCH ON CHILDREN'S MIXED-AGE INTERACTIONS; MEASURES OF LANGUAGE ACCOMMODATION; REFERENCES; PART III:SYMPOSIUM: SEX ROLES AND LANGUAGE; Chapter 13.Perceptions and Politics in Language and Sex Research; ABSTRACT; Key words; REFERENCES; Chapter 14.Language, Thought and Social Attitudes; ABSTRACT; Key words; INTRODUCTION; EXPERIMENT I; METHOD; RESULTS AKD DISCUSSION; EXPERIMENT II: A REPLICATION AM) EXTENSION; METHOD; EESULTS AND DISCUSSION 327 $aGENERAL DISCUSSIONREFERENCES; APPENDIX; Chapter 15.Conversational Dominance as a Function of Gender and Expertise1; ABSTRACT; Key words; INTRODUCTION; METHOD; RESULTS AM) DISCUSSION; REFERENCES; Chapter 16.Sex and Communication: A Brief Presentation of an Experimental Approach; ABSTRACT; Key words; INTRODUCTION; METHOD; RESULTS AND DISCUSSION; CONCLUSION; REFERENCES; Chapter 17.Androgyny, Dyadic Compatibility and Conversational Behaviour1; ABSTRACT; Key words; METHOD; RESULTS; DISCUSSION; REFERENCES; Chapter 18.Judging Masculine and Feminine Social Identities from Content-Controlled Speech 327 $aABSTRACT 330 $aProvides a comprehensive review of the relationships between language and social behaviour. The papers will be of interest not only to psychologists concerned with language and social behaviour, but also to linguists, sociologists and social workers, anthropologists and psychiatrists 606 $aPsycholinguistics$vCongresses 606 $aSociolinguistics$vCongresses 606 $aSocial psychology$vCongresses 615 0$aPsycholinguistics 615 0$aSociolinguistics 615 0$aSocial psychology 676 $a401.9 676 $a401/.9 702 $aGiles$b Howard$f1946- 702 $aRobinson$b William Peter 702 $aSmith$b Philip M.$f1953- 712 12$aInternational Conference on Social Psychology and Language) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910815825803321 996 $aLanguage$958398 997 $aUNINA