LEADER 05500nam 2200685Ia 450 001 9910464764903321 005 20200520144314.0 010 $a1-283-85067-2 010 $a981-4299-79-0 035 $a(CKB)3400000000087207 035 $a(EBL)1080965 035 $a(OCoLC)819070465 035 $a(SSID)ssj0000682433 035 $a(PQKBManifestationID)11390098 035 $a(PQKBTitleCode)TC0000682433 035 $a(PQKBWorkID)10677644 035 $a(PQKB)10181325 035 $a(MiAaPQ)EBC1080965 035 $a(WSP)00002834 035 $a(Au-PeEL)EBL1080965 035 $a(CaPaEBR)ebr10627497 035 $a(CaONFJC)MIL416317 035 $a(EXLCZ)993400000000087207 100 $a20120322d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aChronic hepatitis B and C$b[electronic resource] $ebasic science to clinical applications /$feditor, Chiaho Shih 210 $aSingapore ;$aHackensack, NJ $cWorld Scientific$dc2013 215 $a1 online resource (415 p.) 300 $aDescription based upon print version of record. 311 $a981-4299-78-2 320 $aIncludes bibliographical references and index. 327 $aPreface; Foreword; Contents; Contributors; Hepatitis B Virus; Chapter 1 Natural Course of Chronic Hepatitis B Virus Infection Chia-Ming Chu and Yun-Fan Liaw; Introduction; Epidemiology of Chronic HBV Infection; Clinical Presentation; Phases of Chronic HBV Infection; Immune Tolerant Phase; Immune Clearance Phase; Hepatitis Activity and Acute Hepatitis Flares (HBeAg-positive Chronic Hepatitis) during Immune Clearance Phase; HBeAg to anti-HBe Seroconversion; HBeAg Persistence and Its Outcome; Inactive/Residual Phase; Spontaneous HBsAg Seroclearance; Reactivation of Hepatitis B; HBeAg Reversion 327 $aHBeAg-Negative Chronic HepatitisConcurrent Viral Superinfection as Part of Natural Course; Hepatitic C Virus; Hepatitis D Virus; Human Immunodeficiency Virus; Sequelae and Mortality; Cirrhosis and Contributing Factors; Hepatic Decompensation and Mortality; HCC and Contributing Factors; Survival of Cirrhosis; Conclusion; References; Chapter 2 Immune Response and Viral Hepatitis B David R. Milich; Introduction; Serology of Acute and Chronic HBV Infections; The PreS Envelope Antigens; Increased Complexity of the Serology of Chronic HBV Infection 327 $aHuman T Cell Responses in Acute and Chronic HBV InfectionCD4 + Th Cell Response; CD8 + CTL Response; Innate Immunity to HBV; Mechanisms of Liver Injury and Clearance; Transgenic Models of Immune-mediated Liver Injury; HBV Persistence; Tolerogenicity of HBc/HBeAgs; Immune Escape Variants; Manifestations of HBV-Specific T Cell Tolerance; Immunogenetics; Summary; Acknowledgment; References; Chapter 3 Epidemiology of Viral Hepatitis B-related Hepatocellular Carcinoma Katherine A. McGlynn, Alison A. Evans and W. Thomas London; Introduction; History; Global Prevalence of Chronic HBV Infection 327 $aLiver Cancer Incidence, Mortality, and SurvivalDemographic Factors; Age; Sex; Ethnicity; Risk Factors; Aflatoxin; Alcohol; Tobacco; Pesticides; Iron-related Conditions; Endogenous and Exogenous Hormones; Host Susceptibility; Susceptibility to Chronic HBV Infection; Susceptibility to HCC Once Chronic HBV Infection is Established; Viral Factors; Viral Load; Viral Genotype; Viral Mutations; HBV and Other Cancers; Future Directions and Unresolved Issues; References; Chapter 4 Molecular Biology of HBV-related Hepatocellular Carcinoma Amanda J. Hodgson and Betty L. Slagle; Abstract; Introduction 327 $aLessons from Other Tumor VirusesHBV and HCC; A Model for HBV-associated HCC; Immune-mediated Pathogenesis; Early Immune Response to HBV Infection; Immune-mediated Clearance of HBV; Immune Pathogenesis During Chronic Infection; Effect of HBx on Liver Regeneration; Liver Regeneration in HBV Transgenic Mice; Role of Viral Integration in HCC; General Features of HBV Integration; Lessons Learned from the WHV System; HBV Integration in Human HCCs; Potential Oncogenic Properties of HBV Gene Products; PreS1; PreS2 Truncations; Regulatory HBx Protein; HBx and the Cell Cycle 327 $aActivation of Signal Transduction Pathways 330 $aThe scope of the book is very broad, covering a wide range of areas in HBV/HDV and HCV research, including both basic and clinical science. The selected topics range from epidemiology, immunology, molecular virology and oncology, to clinical therapy.Chronic Hepatitis B and C consists of 14 chapters, each being a review of a special topic on HBV or HCV. While review articles on a special topic can be found in periodical journals, they tend to be more restricted in presentation. Therefore, this book will provide more in-depth coverage of what are presented as "unpublished results" and "data not 606 $aChronic diseases 606 $aHepatitis B$xPathophysiology 606 $aHepatitis C$xPathophysiology 606 $aHepatitis C$xTreatment 608 $aElectronic books. 615 0$aChronic diseases. 615 0$aHepatitis B$xPathophysiology. 615 0$aHepatitis C$xPathophysiology. 615 0$aHepatitis C$xTreatment. 676 $a616.3/623 701 $aShih$b Chiaho$0963908 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910464764903321 996 $aChronic hepatitis B and C$92185938 997 $aUNINA LEADER 03677nam 22006372 450 001 9910454199703321 005 20151005020622.0 010 $a1-107-20194-2 010 $a1-281-98293-8 010 $a9786611982935 010 $a0-511-46324-3 010 $a0-511-46551-3 010 $a0-511-46244-1 010 $a0-511-46477-0 010 $a0-511-75548-1 010 $a0-511-46403-7 035 $a(CKB)1000000000693071 035 $a(EBL)410150 035 $a(OCoLC)437089379 035 $a(SSID)ssj0000254844 035 $a(PQKBManifestationID)11209336 035 $a(PQKBTitleCode)TC0000254844 035 $a(PQKBWorkID)10212267 035 $a(PQKB)10492363 035 $a(UkCbUP)CR9780511755484 035 $a(MiAaPQ)EBC410150 035 $a(Au-PeEL)EBL410150 035 $a(CaPaEBR)ebr10279692 035 $a(CaONFJC)MIL198293 035 $a(EXLCZ)991000000000693071 100 $a20100422d2009|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSynthetic CDOs $emodelling, valuation and risk management /$fCraig Mounfield$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2009. 215 $a1 online resource (xvi, 369 pages) $cdigital, PDF file(s) 225 1 $aMathematics, finance, and risk ;$v7 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a0-521-89788-2 320 $aIncludes bibliographical references (p. 357-363) and index. 327 $a1. A primer on collateralised debt obligations; 2. The modelling of obligor default; 3. Valuation of credit default swaps; 4. Credit indices; 5. Valuation of default baskets; 6. Synthetic CDO valuation methodologies; 7. Phenomenology of the standard market model; 8. Risk quantification and sensitivities of synthetic CDOs; 9. Implied and base correlations; 10. Extensions of the standard market model; 11. Exotic CDOs; 12. Correlation trading of synthetic CDO tranches; 13. Risk management of a portfolio of synthetic CDOs; 14. Hedging simulation of structured credit products; A. Explanation of common notation; B. Simulated annealing. 330 $aCredit derivatives have enjoyed explosive growth in the last decade, particularly synthetic Collateralised Debt Obligations (synthetic CDOs). This book describes the state-of-the-art in quantitative and computational modelling of CDOs. Beginning with an overview of the structured finance landscape, readers are introduced tothe basic modelling concepts necessary to model and value simple credit derivatives. The modelling, valuation and risk management of synthetic CDOs are described and a detailed picture of the behaviour of these complex instruments is built up. The final chapters introduce more advanced topics such as portfolio management of synthetic CDOs and hedging techniques. Detailing the latest models and techniques, this is essential reading for quantitative analysts, traders and risk managers working in investment banks, hedge funds and other financial institutions, and for graduates intending to enter the industry. It is also ideal for academics who need to keep informed with current best practice in the credit derivatives industry. 410 0$aMathematics, finance, and risk ;$v7. 606 $aCollateralized debt obligations 615 0$aCollateralized debt obligations. 676 $a332.63/2 700 $aMounfield$b Craig$f1969-$01034392 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910454199703321 996 $aSynthetic CDOs$92453499 997 $aUNINA LEADER 01377nam 2200385Ka 450 001 9910698369703321 005 20070906154608.0 035 $a(CKB)4330000002020484 035 $a(OCoLC)168553852 035 $a(EXLCZ)994330000002020484 100 $a20070906d2006 ua 0 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aWind energy applications for municipal water services$b[electronic resource] $eopportunities, situation analyses, and case studies : preprint /$fL. Flowers, L. Miner-Nordstrom 210 1$aGolden, CO :$cNational Renewable Energy Laboratory,$d[2006] 215 $a29 pages $cdigital, PDF file 225 1 $aNREL/CP ;$v500-39178 300 $aTitle from title screen (viewed on Sept. 6, 2007). 300 $a"January 2006." 517 $aWind Energy Applications for Municipal Water Services 606 $aWind power$xAnalysis 606 $aWater conservation$zUnited States 615 0$aWind power$xAnalysis. 615 0$aWater conservation 700 $aFlowers$b L$01389157 701 $aMiner-Nordstrom$b L$01400194 712 02$aNational Renewable Energy Laboratory (U.S.) 801 0$bGPO 801 1$bGPO 906 $aBOOK 912 $a9910698369703321 996 $aWind energy applications for municipal water services$93466655 997 $aUNINA