LEADER 03986nam 2200793 450 001 9910464716303321 005 20210422204948.0 010 $a0-231-53795-6 024 7 $a10.7312/ores16954 035 $a(CKB)3710000000113950 035 $a(EBL)1684958 035 $a(SSID)ssj0001193766 035 $a(PQKBManifestationID)12447903 035 $a(PQKBTitleCode)TC0001193766 035 $a(PQKBWorkID)11145982 035 $a(PQKB)10456766 035 $a(StDuBDS)EDZ0001251105 035 $a(MiAaPQ)EBC1684958 035 $a(DE-B1597)458458 035 $a(OCoLC)1002221965 035 $a(OCoLC)1004868115 035 $a(OCoLC)1011438839 035 $a(OCoLC)879946504 035 $a(OCoLC)979683186 035 $a(OCoLC)984641702 035 $a(OCoLC)987921348 035 $a(OCoLC)992483082 035 $a(OCoLC)999354057 035 $a(DE-B1597)9780231537957 035 $a(Au-PeEL)EBL1684958 035 $a(CaPaEBR)ebr10871898 035 $a(CaONFJC)MIL614893 035 $a(EXLCZ)993710000000113950 100 $a20140531h20142014 uy 0 101 0 $aeng 135 $aur|nu---|u||u 181 $ctxt 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe collapse of western civilization $ea view from the future /$fNaomi Oreskes and Erik M. Conway 210 1$aNew York, New York :$cColumbia University Press,$d2014. 210 4$dİ2014 215 $a1 online resource (105 p.) 300 $aDescription based upon print version of record. 311 $a0-231-16954-X 320 $aIncludes bibliographical references. 327 $tFront matter --$tContents --$tAcknowledgments --$tIntroduction --$t1. The Coming of the Penumbral Age --$t2. The Frenzy of Fossil Fuels --$t3. Market Failure --$tEpilogue --$tLexicon of Archaic Terms --$tInterview with the Authors --$tNotes --$tAbout the Authors 330 $aThe year is 2393, and the world is almost unrecognizable. Clear warnings of climate catastrophe went ignored for decades, leading to soaring temperatures, rising sea levels, widespread drought and-finally-the disaster now known as the Great Collapse of 2093, when the disintegration of the West Antarctica Ice Sheet led to mass migration and a complete reshuffling of the global order. Writing from the Second People's Republic of China on the 300th anniversary of the Great Collapse, a senior scholar presents a gripping and deeply disturbing account of how the children of the Enlightenment-the political and economic elites of the so-called advanced industrial societies-failed to act, and so brought about the collapse of Western civilization. In this haunting, provocative work of science-based fiction, Naomi Oreskes and Eric M. Conway imagine a world devastated by climate change. Dramatizing the science in ways traditional nonfiction cannot, the book reasserts the importance of scientists and the work they do and reveals the self-serving interests of the so called "carbon combustion complex" that have turned the practice of science into political fodder. Based on sound scholarship and yet unafraid to speak boldly, this book provides a welcome moment of clarity amid the cacophony of climate change literature. 606 $aCivilization, Western$xForecasting 606 $aCivilization, Western$y21st century 606 $aScience and civilization 606 $aProgress$xForecasting 606 $aTwenty-first century$vForecasts 608 $aElectronic books. 615 0$aCivilization, Western$xForecasting. 615 0$aCivilization, Western 615 0$aScience and civilization. 615 0$aProgress$xForecasting. 615 0$aTwenty-first century 676 $a909/.09821 700 $aOreskes$b Naomi$0793631 702 $aConway$b Erik M. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910464716303321 996 $aThe collapse of western civilization$92442951 997 $aUNINA LEADER 04942nam 2201345z- 450 001 9910557666403321 005 20220111 035 $a(CKB)5400000000044842 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/76871 035 $a(oapen)doab76871 035 $a(EXLCZ)995400000000044842 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDrug-Drug Interactions 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 online resource (242 p.) 311 08$a3-0365-2035-X 311 08$a3-0365-2036-8 330 $aDrug-drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient. Traditionally, DDI have been evaluated around the selective action of drugs on specific CYP enzymes. The interaction of drugs with CYP remains very important in drug interactions but, recently, other important mechanisms have also been studied as contributing to drug interaction including transport- or UDP-glucuronyltransferase as a Phase II reaction-mediated DDI. In addition, novel mechanisms of regulating DDIs can also be suggested. In the case of the substance targeted for interaction, not only the DDIs but also the herb-drug or food-drug interactions have been reported to be clinically relevant in terms of adverse side effects. Reporting examples of drug interactions on a marketed drug or studies on new mechanisms will be very helpful for preventing the side effects of the patient taking these drugs. This Special Issue aims to highlight current progress in understanding both the clinical and nonclinical interactions of commercial drugs and the elucidation of the mechanisms of drug interactions. 606 $aBiology, life sciences$2bicssc 606 $aResearch & information: general$2bicssc 610 $a(?)-sophoranone 610 $a1A2 610 $a2B6 610 $a2C19 610 $a2C8 610 $a2C9 610 $a2D6 610 $a3A4 610 $aADME 610 $aadverse drug reactions 610 $abiflavonoid 610 $achronic kidney disease 610 $acompetitive inhibition 610 $acomputational prediction 610 $aCYP 610 $aCYP1A1 610 $aCYP1A2 610 $aCYP2C9 610 $aCYP2D6 610 $aCYP3A 610 $aCYP3A4 610 $acytochrome P450 610 $acytochromes P450 610 $aDDI 610 $aDexamethasone 610 $adrug interaction 610 $adrug interactions 610 $adrug metabolism 610 $adrug transporter 610 $adrug-drug interaction 610 $adrug-drug interaction 610 $adrug-drug interactions 610 $adrug-drug interactions 610 $aexpression 610 $afexofenadine 610 $agepants 610 $ahigh plasma protein binding 610 $ain silico 610 $ain vitro 610 $ain vivo 610 $ainhibitor 610 $aixazomib 610 $aKetoconazole 610 $alasmiditan 610 $aLexicomp 610 $alow permeability 610 $aLoxoprofen 610 $amechanism-based inhibition 610 $ametabolic DDI 610 $ametabolism 610 $amigraine 610 $amonoclonal antibodies 610 $anon-competitive inhibition 610 $aO-desmethyltramadol 610 $aOATP1B1 610 $aOATP1B3 610 $aorganic anion transporting polypeptide 1A2 (OATP1A2) 610 $aP-glycoprotein (P-gp) 610 $aP450 610 $apharmacokinetics 610 $aphysiologically-based pharmacokinetics 610 $aplasma concentration 610 $apolypharmacy 610 $apotent inhibition 610 $aQSAR 610 $aregulation 610 $aRumex acetosa 610 $aselamariscina A 610 $asignal detection algorithms 610 $aspontaneous reporting systems 610 $asubset analysis 610 $asubstrate 610 $asystemic exposure 610 $atadalafil 610 $aticagrelor 610 $atissue-specific 610 $atramadol 610 $atyrosine kinase inhibitors 610 $aubiquitination 610 $auridine 5'-diphosphoglucuronosyl transferase 615 7$aBiology, life sciences 615 7$aResearch & information: general 700 $aKim$b Dong Hyun$4edt$01304704 702 $aLee$b Sangkyu$4edt 702 $aKim$b Dong Hyun$4oth 702 $aLee$b Sangkyu$4oth 906 $aBOOK 912 $a9910557666403321 996 $aDrug-Drug Interactions$93027633 997 $aUNINA