LEADER 05035nam 2200649 450 001 9910464651903321 005 20200520144314.0 010 $a3-11-027896-0 010 $a3-11-038142-7 024 7 $a10.1515/9783110278965 035 $a(CKB)3360000000514920 035 $a(EBL)1094235 035 $a(SSID)ssj0001401390 035 $a(PQKBManifestationID)12594288 035 $a(PQKBTitleCode)TC0001401390 035 $a(PQKBWorkID)11350293 035 $a(PQKB)11311200 035 $a(MiAaPQ)EBC1094235 035 $a(DE-B1597)175331 035 $a(OCoLC)898422381 035 $a(OCoLC)979745314 035 $a(DE-B1597)9783110278965 035 $a(Au-PeEL)EBL1094235 035 $a(CaPaEBR)ebr11006651 035 $a(CaONFJC)MIL807980 035 $a(EXLCZ)993360000000514920 100 $a20140701h20152015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAnimal cell biotechnology $ein biologics production /$fedited by Hansjo?rg Hauser, Roland Wagner 210 1$aBerlin ;$aBoston :$cWalter de Gruyter GmbH & Company KG,$d[2015] 210 4$d©2015 215 $a1 online resource (718 p.) 300 $aDescription based upon print version of record. 311 $a3-11-027886-3 320 $aIncludes bibliographical references and index. 327 $aUse and perspectives of animal cell culture / Roland Wagner, Hansjo?rg Hauser -- Generation of cell lines and biotechnological applications / Christoph Lipps, Tobias May, Dagmar Wirth -- Cho history, cho evolution and cho genomics : an unsolvable enigma? / Florian Wurm -- Cell lines for vaccine production / Ingo Jordan, Volker Sandig -- Molecular cytogenetics characterization / Roderick A.F. MacLeod, Hans G. Drexler -- Cross-contamination and microbiological contaminations / Wilhelm G. Dirks, Cord C. Uphoff -- Cell line evolution and engineering / Hitto Kaufmann -- Gene amplification and chromosomes / Takeshi Omasa, Kyoungho Lee -- Synthetic mammalian designer cells / David Ausla?nder, Martin Fussenegger -- Rational approaches for transgene expression : targeted integration and episomal maintenance / Natascha Kruse, Shawal Spencer, Dagmar Wirth -- Manipulation of cell growth, metabolism and product quality attributes / Hans Henning von Horsten, Karsten Winkler, Volker Sandig -- Control of biotherapeutics glycosylation / Sandra V. Bennun, Kelley M. Heffner, Emily Blake, Andrew Chung, Michael J. Betenbaugh -- Manufacturing of complex protein products / Lore Florin, Søren K. Rasmussen, Torben P. Frandsen, Anne B. Tolstrup -- Physiology and metabolism of animal cells for production / Venkata Tayi, Michael Butler -- Functional omics for cell lines and processes / Karina Brinkrolf, Raimund Hoffrogge, Matthias Hackl, Andreas Tauch, Martina Baumann, Thomas Noll, Alexander Goesmann, Alfred Pu?hler, Nicole Borth -- Nutrient media for cell culture technology / Claudia Altamirano, Julio Berrios, Mauricio Vergara -- Bioreactors for animal cell culture / Detlef Eisenkraetzer -- High cell density cultivation processes / Natalia Ceaglio, Mariela Bollati-Fogoli?n, Marcos Oggero, Marina Etcheverrigaray, Ricardo B. Kratje -- Industrial cell culture process scale-up strategies and considerations / Weiwei Hu, Kelly Wiltberger -- Extraction and purification of biologics from cell culture / Nuno Fontes, Jens Vogel -- Concepts and technologies for advanced process monitoring and control / John Paul Smelko, Thomas Ryll, Dethardt Mu?ller -- Analytical techniques and quality control of protein therapeutics / Amy Hong Que, Yang Wang, Steven Ziyi Kan -- Process characterization for upstream and downstream development / Vijay Janakiraman, Matt Westoby, Lin Conley -- Spatiotemporally controlled delivery of biopharmaceuticals / Balder Rebmann, Peter van Hoogevest, Matias Zurbriggen, Wilfried Weber. 330 $aThis book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology. 606 $aAnimal cell biotechnology 606 $aPharmaceutical biotechnology 608 $aElectronic books. 615 0$aAnimal cell biotechnology. 615 0$aPharmaceutical biotechnology. 676 $a660.6 686 $aWX 6603$2rvk 702 $aHauser$b Hansjo?rg$f1949- 702 $aWagner$b Roland$f1956- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910464651903321 996 $aAnimal cell biotechnology$92455978 997 $aUNINA