LEADER 05471nam 2200649Ia 450 001 9910463774003321 005 20200520144314.0 010 $a1-61705-127-6 035 $a(CKB)2670000000402557 035 $a(EBL)1336610 035 $a(OCoLC)855505062 035 $a(SSID)ssj0000950467 035 $a(PQKBManifestationID)12422870 035 $a(PQKBTitleCode)TC0000950467 035 $a(PQKBWorkID)11005766 035 $a(PQKB)10831498 035 $a(MiAaPQ)EBC1336610 035 $a(Au-PeEL)EBL1336610 035 $a(CaPaEBR)ebr10742088 035 $a(CaONFJC)MIL539929 035 $a(OCoLC)852503158 035 $a(EXLCZ)992670000000402557 100 $a20130123d2013 uy 0 101 0 $aeng 135 $aurunu---uuuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMultiple sclerosis and related disorders$b[electronic resource] $eclinical guide to diagnosis, medical management, and rehabilitation /$feditors, Alexander D. Rae-Grant, Robert J. Fox, Francois Bethoux 210 $aNew York $cDemos Medical$dc2013 215 $a1 online resource (xiv, 325 pages) $cillustrations 300 $aDescription based upon print version of record. 311 $a1-936287-75-7 320 $aIncludes bibliographical references and index. 327 $aCover; Title; Copyright; Contents; Contributors; Foreword; Preface; Part I. Basics for Clinicians; 1. History of Multiple Sclerosis; Early Cases of MS; Early Descriptions of MS; Description by Charcot; Early Monographs; Early Reports; Three Landmark Reviews of MS; Theories About Causation; Search for an Infection; Epidemiology; Genetics of MS; Vascular Theory; The Immunological Theory; MS Plaque; Investigations; Cognitive Changes in MS; Therapy; Multiple Sclerosis Societies; References; 2. Overview of Multiple Sclerosis; New Directions in Understanding MS; New Directions in Diagnosing MS 327 $aNew Directions in Monitoring MSNew Directions in Treatment of MS Disease Activity; New Directions in Treatment of MS Symptoms; Greater Recognition of The Importance of Other Health Measures in MS; Embracing a Team Approach To MS; Ongoing Challenges and Future Promise; Bibliography; 3. Pathology and Pathophysiology of Multiple Sclerosis; Demyelination within GM and WM in MS; Inflammation in MS; WM Inflammation in MS; GM Inflammation in MS; Neuronal and Axonal degeneration in MS; Pathophysiology of Neurodegeneration in MS; Summary; References 327 $a4. Epidemiology and Natural History of Multiple SclerosisEpidemiology, Survival, Incidence, and Prevalence of Multiple Sclerosis; Environmental Risk Factors for MS; The Natural History of MS; Environmental Risk Factors and The Natural History of MS; Benign MS; References; 5. Multiple Sclerosis Genetics; Race and Geography; Familial Aggregation; The First Molecular Markers for MS: Human Leukocyte Antigens; Linkage Analysis; MS as A Complex Trait; Genomic Linkage Screens; Missing Heritability; Vitamin D Genetics; Exome and Genome Sequencing; The MHC and MS Susceptibility 327 $aCurrent Directions and LimitationsReferences; Part II. Diagnosis; 6. Symptoms and Signs of Multiple Sclerosis; Illustrative Case; Introduction; Evaluation of Symptoms; Symptom Review by System; Nonspecific Versus Specific Symptoms; Conclusion-Finding Patterns Which Fit Together; References; 7. Diagnosis of Multiple Sclerosis; Diagnostic Criteria: A Very Short History; Diagnosing MS: The Mcdonald Criteria (2010); Defining The Phenomenology of MS; Putting The Mcdonald Criteria (2010) Into Practice; Diagnosing MS by Combined Clinical and MRI Criteria 327 $aThe Utility of Cerebrospinal Fluid Examination in the Diagnosis of MS: Why Do a Lumbar Puncture?Diagnostic Categories Resulting from Applying the Mcdonald Criteria; Limitations of the Mcdonald (2010) Criteria; Future Directions in the Diagnosis of MS; References; 8. Magnetic Resonance Imaging in Multiple Sclerosis; Relevant MRI Physics; Characterization of MS on Conventional MRI; Technical Considerations and Pitfalls; Clinical Applications in Disease Monitoring; MRI Safety; References; 9. Tools and Tests for Multiple Sclerosis; Blood Tests; Lumbar Puncture/Spinal Fluid Analysis 327 $aEvoked Potentials 330 $aMultiple Sclerosis and Related Disorders provides evidence-based data and experience-based guidance for delivering quality long-term care to MS patients. Information on disease history, pathophysiology, and biology is included to provide clinicians with a framework for understanding current diagnosis, monitoring, and treatment strategies for these disorders. In addition to thoroughly reviewing the newest disease-modifying treatments, the authors have devoted significant focus to the symptoms that frequently manifest and their treatment options. Symptoms and functional limitations are the ""fac 606 $aMultiple sclerosis 606 $aMultiple sclerosis$xTreatment 608 $aElectronic books. 615 0$aMultiple sclerosis. 615 0$aMultiple sclerosis$xTreatment. 676 $a616.8/34 701 $aRae-Grant$b Alexander$0849138 701 $aFox$b Robert$f1969-$01044245 701 $aBe?thoux$b Franc?ois$01044246 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910463774003321 996 $aMultiple sclerosis and related disorders$92469755 997 $aUNINA