LEADER 03716nam 2200661 450 001 9910463755703321 005 20200520144314.0 010 $a0-19-937047-8 010 $a0-19-937048-6 010 $a0-19-992915-7 035 $a(CKB)2670000000545519 035 $a(EBL)1647165 035 $a(OCoLC)874563137 035 $a(SSID)ssj0001182829 035 $a(PQKBManifestationID)11639815 035 $a(PQKBTitleCode)TC0001182829 035 $a(PQKBWorkID)11185042 035 $a(PQKB)10589878 035 $a(StDuBDS)EDZ0001446539 035 $a(MiAaPQ)EBC1647165 035 $a(Au-PeEL)EBL1647165 035 $a(CaPaEBR)ebr10852029 035 $a(CaONFJC)MIL584407 035 $a(EXLCZ)992670000000545519 100 $a20140329h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHuntington's disease /$fedited by Gillian Bates, Sarah Tabrizi and Lesley Jones ; Ve?ronique M. Andre? [and thirty seven others], contributors 205 $aFourth edition. 210 1$aNew York :$cOxford University Press,$d2014. 210 4$dİ2014 215 $a1 online resource (513 p.) 225 1 $aOxford Monographs on Medical Genetics 300 $aDescription based upon print version of record. 311 $a0-19-992914-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a""Cover""; ""Huntingtona???s Disease""; ""Series""; ""Copyright""; ""Contents""; ""Contributors""; ""Section one Clinical Aspects of Huntingtona???s Disease""; ""1 Huntingtona???s Disease in a Historical Context""; ""2 Clinical Neurology""; ""3 Neuropsychiatry and Neuropsychology""; ""4 Juvenile Huntingtona???s Disease""; ""5 Premanifest and Early Huntingtona???s Disease""; ""Section two Genetics of Huntingtona???s Disease""; ""6 Genetic and Molecular Studies""; ""7 Epidemiology""; ""8 Genetic Counseling and Testing""; ""Section three Neurobiology of Huntingtona???s Disease"" 327 $a""9 Neuropathology in the Human Brain""""10 Altered Neuronal Circuitry""; ""Section Four Molecular Biology of Huntingtona???s Disease""; ""11 Normal Function of Huntingtin""; ""12 Structural Biology: Order, Disorder, and Conformational Flux""; ""13 Pathogenic Mechanisms""; ""14 Peripheral Pathology""; ""Section five Therapeutic Interventions in Huntingtona???s Disease""; ""15 Comprehensive Care""; ""16 Preclinical Experimental Therapeutics""; ""17 Experimental Therapeutics: Moving Forward in Clinical Trials""; ""Index"" 330 $aThis fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections: DT Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages DT The genetics of Huntington 410 0$aOxford monographs on medical genetics. 606 $aHuntington's chorea 608 $aElectronic books. 615 0$aHuntington's chorea. 676 $a616.85/1 702 $aBates$b Gillian 702 $aTabrizi$b Sarah 702 $aJones$b Lesley$f1957- 702 $aAndre?$b Ve?ronique M. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910463755703321 996 $aHuntington's disease$92007245 997 $aUNINA