LEADER 00859nam0-22003011i-450- 001 990004827280403321 005 20161026102737.0 035 $a000482728 035 $aFED01000482728 035 $a(Aleph)000482728FED01 035 $a000482728 100 $a19990604g19 ?9999km-y0itay50------ba 101 0 $aeng 102 $aGB 105 $ay-------001yy 200 1 $a<>poetical works$ewith explanatory notes$fof Henry Wadsworth Longfellow 210 $aLondon$cHumphrey Milford Oxford University Press$d[19 ?] 215 $av.$d16 cm 225 1 $a<>world's classics$v39 327 0 $a1. v. 676 $a811.4 700 1$aLongfellow,$bHenry Wadsworth$f<1807-1882>$0193061 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990004827280403321 952 $aVX LO 24$bFil. Mod.$fFLFBC 959 $aFLFBC 997 $aUNINA LEADER 04676nam 2200685 a 450 001 9910463349203321 005 20200520144314.0 010 $a3-11-026037-9 024 7 $a10.1515/9783110260373 035 $a(CKB)2670000000328236 035 $a(EBL)893175 035 $a(OCoLC)826482554 035 $a(SSID)ssj0000819052 035 $a(PQKBManifestationID)11463154 035 $a(PQKBTitleCode)TC0000819052 035 $a(PQKBWorkID)10844224 035 $a(PQKB)10951172 035 $a(MiAaPQ)EBC893175 035 $a(DE-B1597)171778 035 $a(OCoLC)880404765 035 $a(OCoLC)948656048 035 $a(DE-B1597)9783110260373 035 $a(Au-PeEL)EBL893175 035 $a(CaPaEBR)ebr10649214 035 $a(EXLCZ)992670000000328236 100 $a20120801d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aKallikrein-related peptidases$b[electronic resource] $hVolume 1$iCharacterization, regulation, and interactions within the protease web /$fViktor Magdolen ... [et al.], editors 210 $aBerlin $cWalter de Gruyter$dc2012 215 $a1 online resource (428 p.) 225 0 $aKallikrein-related peptidases ;$vVolume 1 300 $aDescription based upon print version of record. 311 $a3-11-048151-0 311 $a3-11-026036-0 320 $aIncludes bibliographical references and index. 327 $aGenomic structure of the KLK locus -- Single nucleotide polymorphisms in the human KLK locus and their implication in various diseases -- Evolution of Kallikrein-related peptidases -- Structural aspects of Kallikrein-related peptidases -- Molecular recognition properties of Kallikrein-related peptidases on synthetic and endogenous substrates -- Natural, engineered, and synthetic inhibitors of Kallikrein-related peptidases -- Kallikrein-related peptidases as pharmaceutical targets -- Expression of Kallikrein-related peptidases under (patho) physiological conditions -- Kallikrein-related peptidases within the proteolytic web -- Kallikrein-Kinin cascade: bioregulation by human tissue kallikrein 1 (HK1, KLK 1) -- Role of KLK4 in dental enamel formation. 327 $aKallikrein-related peptidases and semen -- Kallikrein-related peptidases and inhibitors of the skin -- Physiological and pathophysiological roles of Kallikrein-related peptidases in the central nervous system -- Kallikrein-related peptidases (KLKS), proteinase-mediated signaling and proteinase-activated receptors (PARS) -- Pathophysiology of Kallikrein-related peptidases in lung cancer -- Clinical relevance of Kallikrein-related peptidases in gastric and colorectal cancer -- Pathophysiology of Kallikrein-related peptidases in head and neck cancer -- PSA (prostate-specific antigen) and other Kallikrein-related peptidases in prostate cancer -- Cellular model systems to study the tumor biological role of Kallikrein-related peptidases in ovarian and prostate cancer -- Clinical relevance of Kallikrein-related peptidases in breast cancer -- Clinical relevance of Kallikrein-related peptidases in ovarian cancer -- MicroRNAs : a new control mechanism for Kallikrein-related peptidases in kidney and other cancers -- Genomic instability of the KLK-locus in cancer -- Kallikrein-related peptidases as biomarkers in personalized cancer medicine. 330 $aThis handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function. 606 $aKallikrein$xGenetics 606 $aKallikrein$xMetabolism 606 $aTumors$xGenetics 606 $aProteolytic enzymes$xMetabolism 608 $aElectronic books. 615 0$aKallikrein$xGenetics. 615 0$aKallikrein$xMetabolism. 615 0$aTumors$xGenetics. 615 0$aProteolytic enzymes$xMetabolism. 676 $a616.99/4042 701 $aMagdolen$b Viktor$01029981 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910463349203321 996 $aKallikrein-related peptidases$92491565 997 $aUNINA