LEADER 05654nam 2200697 450 001 9910462987203321 005 20200520144314.0 010 $a1-118-77041-2 010 $a1-118-77032-3 035 $a(CKB)2670000000494036 035 $a(EBL)1574360 035 $a(SSID)ssj0001061495 035 $a(PQKBManifestationID)11669498 035 $a(PQKBTitleCode)TC0001061495 035 $a(PQKBWorkID)11099229 035 $a(PQKB)11605705 035 $a(MiAaPQ)EBC1574360 035 $a(DLC) 2013030467 035 $a(Au-PeEL)EBL1574360 035 $a(CaPaEBR)ebr10881248 035 $a(CaONFJC)MIL615346 035 $a(OCoLC)854761798 035 $a(EXLCZ)992670000000494036 100 $a20140619h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPhysicochemical and biomimetic properties in drug discovery $echromatographic techniques for lead optimization /$fKlara Valko 210 1$aHoboken, New Jersey :$cWiley,$d2014. 210 4$dİ2014 215 $a1 online resource (581 p.) 300 $aDescription based upon print version of record. 311 $a1-118-15212-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title Page; Copyright; Preface; Chapter 1: The Drug Discovery Process; Summary; Question for Review; References; Chapter 2: Drug-Likeness and Physicochemical Property Space of known Drugs; Summary; Questions for Review; References; Chapter 3: Basic Pharmacokinetic Properties; Absorption; Plasma Protein Binding; Distribution; Volume of Distribution; Unbound Volume of Distribution; Half-Life; Metabolism and Clearance; Free Drug Hypothesis; Summary; Questions for Review; References; Chapter 4: Principles and Methods of Chromatography for the Application of Property Measurements 327 $aTheoretical Background of ChromatographyRetention Factor and its Relation to the Distribution Constant Between the Mobile and the Stationary Phases; Measure of Separation Efficiency; Resolution and Separation Time; Gradient Elution; Applicability of Chromatography for Measurements of Molecular Properties; Summary; Questions for Review; References; Chapter 5: Molecular Physicochemical Properties that Influence Absorption and Distribution-Lipophilicity; Partition Coefficient; Lipophilicity Measurements by Reversed Phase Chromatography with Isocratic Elution 327 $aLipophilicity Measurements by Reversed Phase Chromatography with Gradient ElutionLipophilicity of Charged Molecules-pH Dependence of Lipophilicity; Biomimetic Lipophilicity Measurements by Chromatography; Comparing Various Lipophilicity Measures by the Solvation Equation Model; Summary; Questions for Review; References; Chapter 6: Molecular Physicochemical Properties that Influence Absorption and Distribution-Solubility; Definition of Solubility; Molecular Interactions with Water; Various Solubility Measurements that can be Applied During the Drug Discovery Process 327 $aConditions that Affect SolubilitySolubility-pH Profile; Solubility and Dissolution in Biorelevant Media; Composition of Fasted State Simulated Intestinal Fluid (FaSSIF); Preparation of FaSSIF Solution; Composition of Fed State Simulated Intestinal Fluid (FeSSIF); Preparation of FeSSIF Solution; Summary; Questions for Review; References; Chapter 7: Molecular Physicochemical Properties that Influence Absorption and Distribution-Permeability; Biological Membranes; Artificial Membranes; Physicochemical Principles of Permeability; Experimental Methods to Measure Artificial Membrane Permeability 327 $aRelationships Between Permeability, Lipophilicity, and SolubilityChromatography as a Potential Tool for Measuring the Rate of Permeation; Summary; Questions for Review; References; Chapter 8: Molecular Physicochemical Properties that Influence Absorption and Distribution-Acid Dissociation Constant-pKa; Definition of pKa; Methods for Determining pKa; Spectrophotometric Determination of pKa; Determination of pKa by Capillary Electrophoresis; Chromatographic Approaches for the Determination of pKa; Summary; Questions for Review; References 327 $aChapter 9: Models with Measured Physicochemical and Biomimetic Chromatographic Descriptors-Absorption 330 $aDemonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measure 606 $aDrug development$xStatistical methods 606 $aChromatographic analysis 606 $aClinical trials$xStatistical methods 606 $aPharmaceutical biotechnology 608 $aElectronic books. 615 0$aDrug development$xStatistical methods. 615 0$aChromatographic analysis. 615 0$aClinical trials$xStatistical methods. 615 0$aPharmaceutical biotechnology. 676 $a615.1/9 700 $aValko?$b Kla?ra$0995159 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910462987203321 996 $aPhysicochemical and biomimetic properties in drug discovery$92279527 997 $aUNINA