LEADER 05512nam 2200721Ia 450 001 9910462305603321 005 20200520144314.0 010 $a0-19-932281-3 010 $a1-280-67997-2 010 $a9786613656902 010 $a0-19-984259-0 035 $a(CKB)2670000000203386 035 $a(EBL)931256 035 $a(OCoLC)794664537 035 $a(SSID)ssj0000621025 035 $a(PQKBManifestationID)11926329 035 $a(PQKBTitleCode)TC0000621025 035 $a(PQKBWorkID)10616113 035 $a(PQKB)10478850 035 $a(StDuBDS)EDZ0000126993 035 $a(MiAaPQ)EBC931256 035 $a(WaSeSS)Ind00029637 035 $a(Au-PeEL)EBL931256 035 $a(CaPaEBR)ebr10569236 035 $a(CaONFJC)MIL365690 035 $a(EXLCZ)992670000000203386 100 $a20110615d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aJasper's basic mechanisms of the epilepsies$b[electronic resource] /$fedited by Jeffrey L. Noebels ... [et al.] 205 $a4th ed. 210 $aOxford ;$aNew York $cOxford University Press$dc2012 215 $a1 online resource (1258 p.) 225 1 $aContemporary neurology series ;$v80 300 $aDescription based upon print version of record. 311 $a0-19-974654-0 320 $aIncludes bibliographical references and index. 327 $aCover; Contents; Contributors; SECTION 1 INTRODUCTION; 1. THE NEXT DECADE OF RESEARCH IN THE BASIC MECHANISMS OF THE EPILEPSIES; SECTION 1: INTRODUCTION; SECTION 2: FUNDAMENTALS OF NEURONAL EXCITABILITY RELEVANT TO SEIZURES AND EPILEPSY; SECTION 3: MECHANISMS OF SEIZURE SUSCEPTIBILITY AND EPILEPTOGENESIS; SECTION 4: EPILEPSY GENES AND DEVELOPMENT; SECTION 5: EPILEPSY THERAPEUTICS; CLOSING SUMMARY; 2. HERBERT H. JASPER AND THE BASIC MECHANISMS OF THE EPILEPSIES; THE EARLY YEARS; WORK AT THE MONTREAL NEUROLOGICAL INSTITUTE; THE FOUNDING OF IBRO AND THE BME PROJECT 327 $aMOVING TO THE OTHER SIDE OF THE MOUNTAIN (MONT ROYAL, OF COURSE!)HERBERT JASPER'S LATE YEARS; APPENDIX: ORIGINAL CURRICULUM VITAE OF DR. H. JASPER, DATED APPROXIMATELY 1954; 3. WHY-AND HOW-DO WE APPROACH BASIC EPILEPSY RESEARCH?; WHAT DO WE MEAN BY "BASIC" RESEARCH?; WHAT CAN WE ACCOMPLISH BY ENGAGING IN BASIC RESEARCH?; WHY DO BASIC EPILEPSY RESEARCH?; HOW DO WE CHOOSE AND PRIORITIZE RESEARCH GOALS?; WHAT APPROACHES-CONCEPTUAL OR TECHNICAL-ARE LIKELY TO YIELD SIGNIFICANT RESULTS?; CONCLUDING THOUWGHTS; SECTION 2 FUNDAMENTALS OF NEURONAL EXCITABILITY RELEVANT TO SEIZURES AND EPILEPSY 327 $a4. VOLTAGE-GATED NA[sup(+)] CHANNELS: STRUCTURE, FUNCTION, AND PATHOPHYSIOLOGYNA[sup(+)] CHANNEL SUBUNIT STRUCTURE; Na[sup(+)] CHANNEL GENES; MOLECULAR BASIS OF Na[sup(+)] CHANNEL FUNCTION; THREE-DIMENSIONAL STRUCTURE OF Na[sup(+)] CHANNELS; EXPRESSION, LOCALIZATION, AND FUNCTION OF Na[sup(+)] CHANNEL SUBTYPES IN THE NERVOUS SYSTEM; Na[sup(+)] CHANNEL PHARMACOLOGY; Na[sup(+)] CHANNEL AND EPILEPSY; GENETIC Na[sup(+)] CHANNELOPATHIES; FUTURE DEVELOPMENTS AND CHALLENGES; 5. POTASSIUM CHANNELS (INCLUDING KCNQ) AND EPILEPSY 327 $aK[sup(+)] CHANNELS: A DIVERSE SUPERFAMILY DERIVED FROM AN EXTRAORDINARILY USEFUL TEMPLATEKCNQ CHANNELS: FROM CHANNELOPATHY TO NOVEL THERAPY; KCNQ CHANNELS AND BEYOND: PROSPECTS FOR FUTURE POTASSIUM CHANNEL STUDIES IN EPILEPSY RESEARCH; 6. VOLTAGE-GATED CALCIUM CHANNELS IN EPILEPSY; CALCIUM CHANNEL NOMENCLATURE; CALCIUM CHANNEL BIOPHYSICAL PROPERTIES; CALCIUM CHANNELS AND EXCITABILITY; CALCIUM CHANNELS IN ABSENCE EPILEPSY; CALCIUM CHANNELS IN TEMPORAL LOBE/COMPLEX PARTIAL EPILEPSY; CALCIUM CHANNELS IN GENERALIZED CONVULSIVE SEIZURES; CONCLUSIONS 327 $a7. HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) ION CHANNELOPATHY IN EPILEPSYHCN CHANNEL BIOPHYSICAL PROPERTIES; HCN CHANNEL EFFECTS ON NEURONAL EXCITABILITY; CONTRIBUTION OF HCN CHANNELS TO EPILEPSY; CONCLUSIONS; 8. PHASIC GABA[sub(A)]-MEDIATED INHIBITION; GABA[sub(A)]-MEDIATED IPSCS: PRESYNAPTIC REGULATION; DYNAMICS OF GABA TRANSIENTS IN THE SYNAPTIC CLEFT; GABA[sub(A)]-MEDIATED IPSCS: POSTSYNAPTIC REGULATION; FUTURE PERSPECTIVES; 9. TONIC GABA[sub(A)] RECEPTOR-MEDIATED SIGNALING IN EPILEPSY; GABA[sub(A)] RECEPTOR SUBTYPES UNDERLYING TONIC CONDUCTANCES 327 $aFUNCTIONS OF TONIC GABA[sub(A)] RECEPTOR CURRENTS 330 $aH.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a ""better understanding of the epilepsies and seek more rational methods of their prevention and treatment."" Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it shou 410 0$aContemporary neurology series ;$v80. 606 $aEpilepsy 606 $aConvulsions 608 $aElectronic books. 615 0$aEpilepsy. 615 0$aConvulsions. 676 $a616.8/53 701 $aJasper$b Herbert H$g(Herbert Henri),$f1906-1999.$0860422 701 $aNoebels$b Jeffrey L$0860423 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910462305603321 996 $aJasper's basic mechanisms of the epilepsies$91919752 997 $aUNINA