LEADER 05582nam 22007333u 450 001 9910461651003321 005 20210108101615.0 010 $a0-470-97988-7 010 $a1-119-95766-4 035 $a(CKB)2670000000176984 035 $a(EBL)693297 035 $a(OCoLC)784881826 035 $a(SSID)ssj0000476918 035 $a(PQKBManifestationID)11913382 035 $a(PQKBTitleCode)TC0000476918 035 $a(PQKBWorkID)10480289 035 $a(PQKB)10535467 035 $a(MiAaPQ)EBC693297 035 $a(EXLCZ)992670000000176984 100 $a20140106d2011|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBuilding Brains$b[electronic resource] $eAn Introduction to Neural Development 210 $aHoboken $cWiley$d2011 215 $a1 online resource (350 p.) 300 $aDescription based upon print version of record. 311 $a0-470-71229-5 327 $aBuilding Brains: An Introduction to Neural Development; Contents; Preface; Conventions and Commonly used Abbreviations; 1 Models and Methods for Studying Neural Development; 1.1 What is neural development?; 1.2 Why research neural development?; 1.2.1 The uncertainty of current understanding; 1.2.2 Implications for human health; 1.2.3 Implications for future technologies; 1.3 Major breakthroughs that have contributed to understanding developmental mechanisms; 1.4 Invertebrate model organisms; 1.4.1 Fly; 1.4.2 Worm; 1.4.3 Other invertebrates; 1.5 Vertebrate model organisms; 1.5.1 Frog 327 $a1.5.2 Chick1.5.3 Zebrafish; 1.5.4 Mouse; 1.5.5 Humans; 1.5.6 Other vertebrates; 1.6 Observation and experiment: methods for studying neural development; 1.7 Summary; 2 The Anatomy of Developing Nervous Systems; 2.1 The nervous system develops from the embryonic neuroectoderm; 2.2 Anatomical terms used to describe locations in embryos; 2.3 Development of the neuroectoderm of invertebrates; 2.3.1 C. elegans; 2.3.2 Drosophila; 2.4 Development of the neuroectoderm of vertebrates and the process of neurulation; 2.4.1 Frog; 2.4.2 Chick; 2.4.3 Mouse; 2.5 Secondary neurulation in vertebrates 327 $a2.6 Formation of invertebrate and vertebrate peripheral nervous systems2.6.1 Invertebrates; 2.6.2 Vertebrates: the neural crest and the placodes; 2.6.3 Vertebrates: development of sense organs; 2.7 Summary; 3 Neural Induction: An Example of How Intercellular Signalling Determines Cell Fates; 3.1 What is neural induction?; 3.2 Specification and commitment; 3.3 The discovery of neural induction; 3.4 A more recent breakthrough: identifying molecules that mediate neural induction; 3.5 Conservation of neural induction mechanisms in Drosophila 327 $a3.6 Beyond the default model - other signalling pathways involved in neural induction3.7 Signal transduction: how cells respond to intercellular signals; 3.8 Intercellular signalling regulates gene expression; 3.8.1 General mechanisms of transcriptional regulation; 3.8.2 Transcription factors involved in neural induction; 3.8.3 What genes do transcription factors control?; 3.8.4 Gene function can also be controlled by other mechanisms; 3.9 The essence of development: a complex interplay of intercellular and intracellular signalling; 3.10 Summary; 4 Patterning the Neuroectoderm 327 $a4.1 Regional patterning of the nervous system4.1.1 Patterns of gene expression are set up by morphogens; 4.1.2 Patterning occurs within a monolayer epithelium; 4.1.3 Patterning happens progressively; 4.2 Patterning the anteroposterior (AP) axis of the DrosophilaCNS; 4.2.1 Creating domains of transcription factor expression; 4.2.2 Dividing the ectoderm into segmental units; 4.2.3 Assigning segmental identity - the Hox code; 4.3 Patterning the AP axis of the vertebrate CNS; 4.3.1 Hox genes are highly conserved; 4.3.2 Initial AP information is imparted by the mesoderm 327 $a4.3.3 Mesoderm signals set up domains of transcription factor expression 330 $aThe development of a brain from its simple beginnings in the embryo to the extraordinarily complex fully-functional adult structure is a truly remarkable process. Understanding how it occurs remains a formidable challenge despite enormous advances over the last century and current intense world-wide scientific research. A greater knowledge of how nervous systems construct themselves will bring huge benefits for human health and future technologies. Unravelling the mechanisms that lead to the development of healthy brains should help scientists tackle currently incurable diseases of the nervous 606 $aDevelopmental neurobiology 606 $aNervous system --Growth 606 $aDevelopmental neurobiology$xGrowth 606 $aNervous system 606 $aNeurons$xphysiology 606 $aNervous System$xanatomy & histology 606 $aNeurogenesis 608 $aElectronic books. 615 4$aDevelopmental neurobiology. 615 4$aNervous system --Growth. 615 0$aDevelopmental neurobiology$xGrowth 615 0$aNervous system 615 12$aNeurons$xphysiology. 615 22$aNervous System$xanatomy & histology. 615 22$aNeurogenesis. 676 $a612.8 700 $aPrice$b David$0543765 701 $aJarman$b Andrew P$0878007 701 $aMason$b John O$0140119 701 $aKind$b Peter C$0882352 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910461651003321 996 $aBuilding Brains$91970881 997 $aUNINA