LEADER 03419nam 2200625 a 450 001 9910461617703321 005 20200520144314.0 010 $a1-283-14332-1 010 $a9786613143327 010 $a1-84816-367-3 035 $a(CKB)2670000000095736 035 $a(EBL)731333 035 $a(OCoLC)738434150 035 $a(SSID)ssj0000524181 035 $a(PQKBManifestationID)12213183 035 $a(PQKBTitleCode)TC0000524181 035 $a(PQKBWorkID)10546100 035 $a(PQKB)11062794 035 $a(MiAaPQ)EBC731333 035 $a(WSP)0000P630 035 $a(Au-PeEL)EBL731333 035 $a(CaPaEBR)ebr10479770 035 $a(CaONFJC)MIL314332 035 $a(EXLCZ)992670000000095736 100 $a20110714d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMicroRNAs in development and cancer$b[electronic resource] /$feditor, Frank J. Slack 210 $aLondon $cImperial College Press$d2011 215 $a1 online resource (300 p.) 225 1 $aMolecular medicine and medicinal chemistry ;$vv. 1 300 $aDescription based upon print version of record. 311 $a1-84816-366-5 320 $aIncludes bibliographical references and index. 327 $aContents; Preface; 1 Introduction to Gene Regulation by Small RNAs Allison L. Abbott; 2 The Emerging Non-Coding RNA World Ahmad M. Khalil, Maite Huarte and John L. Rinn; 3 MicroRNAs in C. elegans Development Helge Großhans and Almuth E. Mu?llner; 4 MicroRNAs in Mammalian Development Andrea Ventura; 5 MicroRNAs in Hematopoietic Development Silvia Monticelli; 6 MicroRNAs Function as Tumor Suppressor Genes and Oncogenes Aurora Esquela-Kerscher; 7 Simultaneous Detection of Primary, Precursor and Mature MicroRNAs by qPCR Jinmai Jiang, Eun Joo Lee and Thomas D. Schmittgen 327 $a8 Single Nucleotide Polymorphisms in MicroRNAs and MicroRNA Binding Sites with Roles in Cancer Lena J. Chin and Frank J. Slack9 MicroRNAs as Potential Diagnostics and Therapeutics Trupti Paranjape, Jae Choi and Joanne B.Weidhaas; 10 MicroRNA Target Prediction Isidore Rigoutsos and Aristotelis Tsirigos; 11 Non-Coding RNAs in Cancer - The Other Part of the Story Muller Fabbri and George A. Calin; Index 330 $aMicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represen 410 0$aMolecular medicine and medicinal chemistry ;$vv. 1. 606 $aCancer$xGenetic aspects 606 $aSmall interfering RNA 608 $aElectronic books. 615 0$aCancer$xGenetic aspects. 615 0$aSmall interfering RNA. 676 $a572.88 701 $aSlack$b Frank J$0961179 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910461617703321 996 $aMicroRNAs in development and cancer$92179084 997 $aUNINA