LEADER 05254nam 2200649 a 450 001 9910461560403321 005 20210525125108.0 010 $a1-283-73506-7 010 $a0-12-386538-7 035 $a(CKB)2670000000172228 035 $a(EBL)892228 035 $a(OCoLC)787852041 035 $a(SSID)ssj0000623278 035 $a(PQKBManifestationID)12293004 035 $a(PQKBTitleCode)TC0000623278 035 $a(PQKBWorkID)10648031 035 $a(PQKB)11457961 035 $a(MiAaPQ)EBC892228 035 $a(PPN)170607690 035 $a(Au-PeEL)EBL892228 035 $a(CaPaEBR)ebr10546058 035 $a(CaONFJC)MIL404756 035 $a(EXLCZ)992670000000172228 100 $a20120123d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPractical process research and development$b[electronic resource] $ea guide for organic chemists /$fNeal G. Anderson 205 $a2nd ed. 210 $aAmsterdam ;$aBoston $cAcademic Press$d2012 215 $a1 online resource (489 p.) 300 $aRev. ed. of: Practical process research & development. c2000. 311 $a1-4933-0125-X 311 $a0-12-386537-9 320 $aIncludes bibliographical references and indexes. 327 $aFront Cover; Dedication; Practical Process Research and Development: A guide for organic chemists; Copyright; Contents; About the Author; Preface to Second Edition; Foreword; REFERENCES; Chapter 1 - Introduction; I. INTRODUCTION; II. EQUIPMENT CONSIDERATIONS ON SCALE; III. OPERATIONS PREFERRED ON SCALE; IV. PATENT CONSIDERATIONS; V. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 2 - Process Safety; I. INTRODUCTION; II. REPERCUSSIONS OF USING COMPOUNDS REGARDED AS ENVIRONMENTAL HAZARDS; III. TOXICOLOGICAL HAZARDS OF COMPOUNDS; IV. CONTROLLING CHEMICAL REACTION HAZARDS; V. PERSPECTIVE ON SAFETY 327 $aREFERENCESChapter 3 - Route Selection; I. INTRODUCTION; II. GREEN CHEMISTRY CONSIDERATIONS; III. BIOTRANSFORMATIONS; IV. SLEUTHING TO DETERMINE ROUTES USED TO MAKE DRUGS; V. COG ESTIMATES; VI. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 4 - Reagent Selection; I. INTRODUCTION; II. BIOCATALYSIS; III. STRONG BASES; IV. PHASE-TRANSFER CATALYSIS; V. PEPTIDE COUPLING; VI. OXIDATIONS; VII. REDUCTIONS; VIII. TREATMENTS TO REMOVE A BOC GROUP; REFERENCES; Chapter 5 - Solvent Selection; I. INTRODUCTION; II. USING AZEOTROPES TO SELECT SOLVENTS 327 $aIII. CHOOSING SOLVENTS TO INCREASE REACTION RATES AND MINIMIZE IMPURITIESIV. IMPURITIES IN SOLVENTS AND REACTIONS OF SOLVENTS; V. WATER AS SOLVENT; VI. SOLVENT SUBSTITUTIONS; VII. SOLVENT-FREE PROCESSES; VIII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 6 - Effects of Water; I. INTRODUCTION; II. DETECTING AND QUANTITATING WATER; III. REMOVING WATER FROM ROUTINE ORGANIC PROCESSING; IV. WHERE TO MONITOR AND CONTROL WATER; V. OPERATIONS TO REMOVE OR CONSUME WATER; VI. OPERATIONS WHERE WATER CAN BE CRUCIAL; VII. PERSPECTIVE; REFERENCES 327 $aChapter 7 - In-Process Assays, In-Process Controls, and SpecificationsI. INTRODUCTION; II. UNDERSTANDING CRITICAL DETAILS BEHIND IN-PROCESS ASSAYS; III. BENEFITS OF IN-PROCESS ASSAYS IN OPTIMIZING PROCESSES; IV. IN-PROCESS CONTROLS; V. SPECIFICATIONS; VI. PROCESS ANALYTICAL TECHNOLOGY; VII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 8 - Practical Considerations for Scale-Up; I. INTRODUCTION; II. SAFETY: INERT ATMOSPHERES REDUCE RISKS; III. TEMPERATURE CONTROL; IV. HETEROGENEOUS PROCESSING AND CONSIDERATIONS FOR AGITATION; V. ADDITIONS AND MIXING CONSIDERATIONS; VI. SOLVENT CONSIDERATIONS 327 $aVII. SIMPLE PROCEDURESVIII. IMPACT OF IPCS ON PROCESSING; IX. CONSIDER THE VOLATILITY OF REACTION COMPONENTS, AND USE OF PRESSURE; X. PRACTICAL CONSIDERATIONS FOR EFFICIENT WORKUPS AND ISOLATIONS; XI. ADDITIONAL CONSIDERATIONS FOR KILO LAB OPERATIONS; XII. SUMMARY AND PERSPECTIVE; REFERENCES; Chapter 9 - Optimizing Processes by Minimizing Impurities; I. INTRODUCTION; II. BENEFITS AND LIMITATIONS OF HETEROGENEOUS PROCESSING; III. DECREASE SIDE PRODUCTS BY DECREASING DEGRADATION OF STARTING MATERIALS; IV. CONTROLLING PH; V. ADDITION SEQUENCE, DURATION OF ADDITION, AND TIME BETWEEN ADDITIONS 327 $aVI. TEMPERATURE CONTROL 330 $a"Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and green chemistry"--$cProvided by publisher. 606 $aChemical processes 608 $aElectronic books. 615 0$aChemical processes. 676 $a541/.39 700 $aAnderson$b Neal G$0990286 701 $aAnderson$b Neal G$0990286 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910461560403321 996 $aPractical process research and development$92265394 997 $aUNINA