LEADER 05316nam 2200637Ia 450 001 9910461493803321 005 20200520144314.0 010 $a1-283-73508-3 010 $a0-12-385927-1 035 $a(CKB)2670000000147356 035 $a(EBL)872582 035 $a(OCoLC)778786624 035 $a(SSID)ssj0000629810 035 $a(PQKBManifestationID)12284086 035 $a(PQKBTitleCode)TC0000629810 035 $a(PQKBWorkID)10732010 035 $a(PQKB)11670751 035 $a(MiAaPQ)EBC872582 035 $a(Au-PeEL)EBL872582 035 $a(CaPaEBR)ebr10554564 035 $a(CaONFJC)MIL404758 035 $a(EXLCZ)992670000000147356 100 $a20120130d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aVeterinary toxicology$b[electronic resource] $ebasic and clinical principles /$fedited by Ramesh C. Gupta 205 $a2nd ed. 210 $aAmsterdam ;$aBoston $cElsevier $cAcademic Press$d2012 215 $a1 online resource (1455 p.) 300 $aPrevious ed.: 2007. 311 $a0-12-385926-3 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Veterinary Toxicology: Basic and Clinical Principles; Copyright Page; Contents; Preface; List of Contributors; I. General; 1 Veterinary toxicology: a historical perspective; The Emergence of Veterinary Toxicology; Professional Organization and Academic Recognition of Veterinary Toxicology; Published Veterinary Toxicology Literature; ...And Where Will Veterinary Toxicology Go From Here?; References; 2 Concepts in veterinary toxicology; Introduction; Historical Perspective; Historical events; Textbooks; Organizations; Evolution of Veterinary Toxicology 327 $aRoots in veterinary medicine and toxicologyEmergence of science-based toxicology; Toxicology joined to the risk paradigm; A Framework for Acquiring Information; Linkages from sources to health impacts; Toxicokinetics; Toxicodynamics; Veterinary toxicology is multi-faceted; Sources of Information; Case observations in the species of interest; Epidemiological/epizootiological studies; Experimentation; Schematic experimental designs; Acquiring toxicokinetic data; Acquiring exposure (dose)-response data; Toxicologic Descriptors; Toxicology rooted in observations; Quantifying exposure 327 $aDescribing absorption, distribution, metabolism and excretionToxicant-induced responses; Describing exposure-response relationships for non-cancer endpoints; Cancer as an endpoint; New potential endpoints; Conclusions and Summary; Dedication; Acknowledgments; References; 3 Toxicokinetics; Introduction; Underlying Physiology; Absorption; Distribution; Biotransformation; Excretion; Traditional (Compartmental) Toxicokinetic Models; Introduction; Measures of absorption; Volume of distribution; Clearance; Half-life; Flip-flop kinetics; Residues; Physiologically Based Toxicokinetics; Introduction 327 $aModel constructionParameter estimation and identifiability; Model validation; Applications; Conclusions; References; 4 Factors affecting chemical toxicity; Introduction; Individual Factors; Species; Anatomical and physiological features; Enzyme expression and biotransformation pathways; Breed; Age; Pathophysiological conditions; Stress; Disease; Pregnancy; Lactation; Non-Individual Factors; Physico-chemical characteristics of the poison; Environmental conditions; Diet; Routes of exposure; Previous or coincident exposure to other chemicals (drug-drug interactions); Conclusion; References 327 $a5 Toxicological testing: in vivo and in vitro modelsIntroduction; In Vivo Models in Toxicity Testing; Introduction; Animal welfare in toxicity testing; Routes of test compound administration; Reproductive toxicity tests; Developmental toxicity testing; Cutaneous toxicity testing; Genotoxicity testing; Carcinogenicity tests; Neurotoxicity; Immunotoxicity; Transgenic animals in toxicity testing; Limitations and implications of animal use in toxicological testing; In Vitro Models of Toxicity Testing; Introduction; Types of cell culture system used in toxicity testing 327 $aEndpoint determination for in vitro testing systems 330 $aVeterinary Toxicology is a unique single reference that teaches the basic principles of veterinary toxicology to any student at the DVM, MS or PhD level and will continue to serve as a clinical reference for practicing veterinary toxicologists, poison control centers, marine biologists, environmentalists, and animal scientists. While most comparable texts are primarily directed toward the field of human toxicology, this is the one text needed to thoroughly prepare future veterinarians on the newest approaches for diagnosing poisoning cases in all animals from chemicals and plants of a d 606 $aVeterinary toxicology 606 $aVeterinary medicine 608 $aElectronic books. 615 0$aVeterinary toxicology. 615 0$aVeterinary medicine. 676 $a636.08959 701 $aGupta$b Ramesh C$g(Ramesh Chandra),$f1949-$0866223 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910461493803321 996 $aVeterinary toxicology$91933285 997 $aUNINA