LEADER 05179nam 2200625 450 001 9910460918103321 005 20191011094745.0 010 $a1-910190-04-7 035 $a(CKB)3710000000355112 035 $a(EBL)1977391 035 $a(SSID)ssj0001466834 035 $a(PQKBManifestationID)11831245 035 $a(PQKBTitleCode)TC0001466834 035 $a(PQKBWorkID)11504597 035 $a(PQKB)10032986 035 $a(MiAaPQ)EBC1977391 035 $a(MiAaPQ)EBC5897829 035 $a(Au-PeEL)EBL5897829 035 $a(OCoLC)904518280 035 $a(EXLCZ)993710000000355112 100 $a20191011d2015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAdvanced vaccine research $emethods for the decade of vaccines /$fedited by Fabio Bagnoli and Rino Rappuoli 210 1$aNorfolk, England :$cCaister Academic Press,$d[2015] 210 4$d©2015 215 $a1 online resource (474 p.) 300 $aDescription based upon print version of record. 311 $a1-910190-03-9 320 $aIncludes bibliographical references and index. 327 $aContents; Contributors; Current Books of Interest; Preface; Part I: Innovative Technologies and Approaches in Vaccine Research; 1: Deep Sequencing in Vaccine Research, Development and Surveillance ; Impact of DNA sequencing on vaccines research and development; Deep sequencing potential to transform vaccinology; 2: New Bioinformatics Algorithms Applied to Deep Sequencing Projects ; Introduction; Better understating of host and pathogen genomes; Computational approaches to study adaptive immune responses; Better understanding of transcriptome 327 $aEpigenomics: understanding of inheritable chemical changesMetagenomics: finding new pathogens and strains; Bioinformatics challenges; 3: Comparative Genomics Approaches for Tracking the Emergence and Spread of Disease-associated Bacteria; Background; Comparative genomics of disease-associated bacteria; Assays for identification of disease-associated bacteria based on insights from comparative genomics; Conclusions; 4: Quantitative Proteomics in Vaccine Research; Introduction; Quantitative proteomics based on gel electrophoresis; Quantitative proteomics based on differential mass tag 327 $aLabel-free technologies and targeted proteomicsMass spectrometry for viral vaccinology; Proteomic technology for vaccine development ; Combining proteomics and system biology to improve vaccines; Concluding remarks; 5: Structural Biology in Vaccine Research; Introduction; Experimental mapping and computational prediction of epitopes; Examples of structural vaccinology for bacterial and viral pathogens; Concluding remarks and future directions; 6: Cellular Screens to Interrogate the Human T- and B-cell Repertoires and Design Better Vaccines ; Introduction 327 $aGeneration of naive B- and T-cell repertoires7: Novel Strategies of Vaccine Administration: The Science Behind Epidermal and Dermal Immunization; Introduction; The skin layers; Skin antigen-presenting cells and other players in vaccination; Principles and methods in skin immunization; Vaccine formulation and immunity; Immunological advantage of epidermal and dermal immunization; 8: Toll-like Receptors as Targets to Develop Novel Adjuvants; Introduction; Innate immunity; TLR-based adjuvants in high-priority vaccines; Lessons learned from studies of TLR agonists as adjuvants 327 $aSafety considerations of TLR agonistsChallenges for the next decade; 9: The Importance of Cell-mediated Immunity for Bacterial Vaccines ; Introduction; T-cell responses to bacterial infection; Targeting cellular immunity for novel anti-bacterial vaccine design; 10: T-cell-inducing Vaccines; Introduction; How can we measure T-cell responses?; Technologies for inducing T-cell responses by vaccination; Heterologous prime-boost immunization; Successful clinical development of T-cell vaccines; 11: Exploiting the Mutanome for Personalized Cancer Immunotherapy 327 $aCancer mutations as therapeutic targets 330 $aSince the publication of our first book book ""Vaccine Design: Innovative Approaches and Novel Strategies"" in 2011, the field of vaccinology has advanced significantly. The application of new sophisticated 'omics' technologies and the use of pioneering approaches have yielded a wealth of new data. This new book aims to distill the most important new findings to provide a timely overview of the field. Written by leading experts in the field, each chapter affords a critical insight to a particular topic, reviews current research, discusses future direction and aims to stimulate discussion. The 606 $aVaccines$xResearch 606 $aDrug development 608 $aElectronic books. 615 0$aVaccines$xResearch. 615 0$aDrug development. 676 $a615.372 702 $aBagnoli$b Fabio 702 $aRappuoli$b Rino 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910460918103321 996 $aAdvanced vaccine research$92229886 997 $aUNINA LEADER 01622nam0 22003371i 450 001 UON00382517 005 20231205104534.697 010 $a978-38-683-5031-9$bv. 366 100 $a20100617d2010 |0itac50 ba 101 $aeng 102 $aDE 105 $a|||| 1|||| 200 1 $aFrom the foundations to the crenellations$eEssays on temple building in the ancient Near East and Hebrew Bible$fEdited by Mark J. Boda and Jamie Novotny 210 $aMunster$cUgerit-Verlag$d2010 215 $aXXXVIII, 627 p.$cill.$d25 cm. 311 $aVOA SERIE 001 366$9UON00000604 316 $av. 366$5IT-UONSI VOASERIE001/(366) 410 0$1001UON00000604$12001 $aAlter Orient und Altes Testament$eVeroffentlichungen zur Kultur und Geschichte des Alten Orients und des Alten Testaments$fHrsg. Manfried Dietrech, Oswald Loretz$v366 VOA SERIE 001 366 606 $aBIBBIA$xVecchio Testamento$xStoria degli avvenimenti biblici$3UONC020532$2FI 606 $aTEMPLI$xMEDIO ORIENTE$xCOSTRUZIONE$3UONC075918$2FI 620 $aDE$dMünster$3UONL001022 686 $aVOA SERIE$cVICINO ORIENTE ANTICO - COLLANE$2A 702 1$aBODA$bMark J.$3UONV197375 702 1$aNOVOTNY$bJamie R.$3UONV155966 712 $aUgarit-Verlag$3UONV251297$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00382517 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI VOA SERIE 001 (366) $eSI SA 127303 7 (366) v. 366 996 $aFrom the foundations to the crenellations$91357744 997 $aUNIOR LEADER 00910nam0-22002891i-450 001 990005365590403321 005 20240229154854.0 035 $a000536559 035 $aFED01000536559 035 $a(Aleph)000536559FED01 035 $a000536559 100 $a19990530d1990----km-y0itay50------ba 101 0 $aita 105 $aa-------00--- 200 1 $aSiculi e greci in Leontinoi$f[Paolo Orsi] 210 $as.l.$cs.e.$d[1990] 215 $a98 p.$cill.$d30 cm 300 $aEstratto dal Bullettino dell'imp. Istituto archeologico germanico Vol. XV - Anno 1900 Fasc. 1-2 700 1$aOrsi,$bPaolo$f<1859-1935>$039218 712 0 $aDeutsches Archäologisches Institut$c 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990005365590403321 952 $aARCH. BM MISC. 012 (11)$bARCH. 14457$fFLFBC 959 $aFLFBC 996 $aSiculi e greci in Leontinoi$9594734 997 $aUNINA