LEADER 05464nam 2200697 450 001 9910460751403321 005 20200903223051.0 010 $a0-12-802593-X 010 $a0-12-802443-7 035 $a(CKB)3710000000353069 035 $a(EBL)1948969 035 $a(SSID)ssj0001548711 035 $a(PQKBManifestationID)16153072 035 $a(PQKBTitleCode)TC0001548711 035 $a(PQKBWorkID)14802547 035 $a(PQKB)11532044 035 $a(MiAaPQ)EBC1948969 035 $a(Au-PeEL)EBL1948969 035 $a(CaPaEBR)ebr11019349 035 $a(CaONFJC)MIL732181 035 $a(OCoLC)903442569 035 $a(EXLCZ)993710000000353069 100 $a20150220h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aVitamins and hormones$hVolume ninety-seven$iNociceptin opioid /$fseries editor, Gerald Litwack 205 $aFirst edition. 210 1$aWaltham, Massachusetts :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (392 p.) 225 1 $aVitamins and Hormones,$x0083-6729 ;$vVolume 97 300 $aDescription based upon print version of record. 311 $a1-336-00899-7 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; Nociceptin Opioid; Copyright; Contents; Contributors; Preface; Chapter 1: Helix-Constrained Nociceptin Peptides Are Potent Agonists and Antagonists of ORL-1 and Nociception; 1. Nociception in Brief; 1.1. Opioid receptor-like receptor-ORL-1; 1.2. Nociceptin; 1.3. Interrogating the activation and address domains of nociceptin(1-17); 2. Prospecting the Importance of the N-Terminal Tetrapeptide of Nociceptin(1-17); 3. Other Modifications to Nociceptin(1-17); 4. The Importance of Structure in Nociceptin Analogues; 4.1. Importance of helicity; 4.2. Other nociceptin derivatives 327 $a5. Recent Advances in ORL-1 Active Nociceptin Peptides6. The Development of New Helix-Constrained Nociceptin Analogues; 6.1. Design of helix-constrained nociceptin analogues; 6.2. Helical structure of nociceptin(1-17)-NH2 analogues in water; 6.3. Nuclear magnetic resonance spectra-derived structures; 7. Biological Properties of Helical Nociceptin Mimetics; 7.1. Cellular expression of ORL-1 and ERK phosphorylation; 7.2. Agonist and antagonist activity of nociceptin(1-17)-NH2 and analogues; 7.3. Effects of helical constraint on biological activity in Neuro-2a cells 327 $a7.4. Stability and cell toxicity of helix-constrained versus unconstrained peptides7.5. In vivo activity of helix-constrained versus unconstrained nociceptin analogues; 8. Concluding Remarks; References; Chapter 2: Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors; 1. Introduction; 1.1. The origin of G protein-coupled receptors; 1.2. A brief history of opioid receptors; 1.3. Evidence for opioid receptors in nonmammalian vertebrates; 2. The Vertebrate Opioid Receptor Sequence Database; 2.1. Alignment of protein sequences 327 $a2.2. Phylogenetic analysis of vertebrate opioid receptors2.3. Divergence and convergence of opioid receptor types; 3. The Human Genome and the Evolution of Opioid Receptors; 3.1. Duplicated opioid family receptor genes in the human genome; 3.2. Variation in human opioid receptor genes; 4. The Molecular Evolution of Vertebrate Opioid Family Receptors; 5. Future Directions; 6. Conclusions; Acknowledgments; References; Chapter 3: Ancestral Vertebrate Complexity of the Opioid System; 1. Introduction; 2. Opioid Peptide Family; 3. Opioid Receptor Family 327 $a4. Discussion: Complexity, Coevolution, and Divergence5. Conclusions; Acknowledgement; References; Chapter 4: Synthesis and Biological Activity of Small Peptides as NOP and Opioid Receptors' Ligands: View on Current Devel...; 1. Introduction; 2. Endogenous Opioid Peptides and Receptors: Nociceptin and NOP Receptor Ligands; 3. Hexapeptides with NOP Receptor Affinity; 4. Solid-Phase Peptide Synthesis; 5. Conclusions; Acknowledgment; References; Chapter 5: Pain Regulation by Nocistatin-Targeting Molecules: G Protein-Coupled-Receptor and Nocistatin-Interacting Protein; 1. Introduction 327 $a2. Biological Activity by NST Through G Protein-Coupled Receptor 330 $aFirst published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on nociceptin opioid. Key features: Expertise of the contributorsCoverage of a vast array of subjectsIn 410 0$aVitamins and hormones ;$vVolume 97. 606 $aNeuropeptides 606 $aOpioid peptides 606 $aNociceptive pain 608 $aElectronic books. 615 0$aNeuropeptides. 615 0$aOpioid peptides. 615 0$aNociceptive pain. 676 $a612.015756 702 $aLitwack$b Gerald 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910460751403321 996 $aVitamins and hormones$9762543 997 $aUNINA