LEADER 04219nam 2200493 450 001 9910460732903321 005 20170918205300.0 010 $a1-68108-134-2 035 $a(CKB)3710000000531583 035 $a(EBL)4412591 035 $a(MiAaPQ)EBC4412591 035 $a(EXLCZ)993710000000531583 100 $a20160614d2015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aDown syndrome children-- and update /$fedited by Mohammed Al-Biltagi, associate professor of pediatrics, Tanta University, Egypt 210 1$aSharjah :$cBentham Science Publishers, Limited,$d[2015] 215 $a1 online resource (486 p.) 300 $aIncludes index. 311 $a1-68108-135-0 327 $aCONTENTS; FOREWORD ; PREFACE ; List of Contributors ; Epidemiology and Prevalence of Down Syndrome ; 1. INTRODUCTION; 2. FACTORS AFFECTING THE RISK OF DOWN SYNDROME; 2.1. Maternal Age at Birth; 2.2. Altered Recombination Patterns Along Chromosome 21; 2.3. Maternal Grandmother Age; 2.4. Paternal Age; 2.5. Consanguinity; 2.6. Parity and Reproductive Function of the Mother; 2.7. Interval Between Pregnancies; 2.8. Previous Child with Down Syndrome; 2.9. Multiple Versus Singleton Pregnancies; 2.10. Environmental Factors 327 $a2.10.1. Impact of Prenatal Diagnosis on the Prevalence of Down Syndrome and Rate of Pregnancy Termination2.10.2. Socioeconomic Status; 2.10.3. Exposure to Chemical Toxins, Drugs and Diseases; 3. PREVALENCE OF DOWN SYNDROME; 3.1. Prevalence in Africa; 3.2. Prevalence in Arab Worlds; 3.3. Prevalence in Asia; 3.4. Prevalence in Australia; 3.5. Prevalence in Europe; 3.6. Prevalence in North America (Fig. 4); 3.7. Prevalence in South America; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Genetics of Down Syndrome: An Update ; 1. INTRODUCTION: CHROMOSOMAL BASIS OF DOWN SYNDROME 327 $a2. ETIOLOGY AND ORIGIN OF EXTRA CHROMOSOME 212.1. Nondisjunction Trisomy 21; 2.2. Robertsonian Translocation; 2.3. Mosaicism; 3. MOLECULAR GENETICS; 3.1. Genes Involved in Cognitive Impairment; 3.2. Genes Involved in Hematological Malignancies; 3.2.1. TAM: A Unique Hematological Finding in DS; 3.2.2. JAK2 Associated ALL in DS; 3.2.3. CBER1 Gene and Anthracycline- Related Cardiotoxicity in DS; 3.3. Genes Involved in Congenital Heart Disease (CHD); 3.4. Genes Involved in Immunological Dysfunctions; 4. THE BLESSING EFFECT OF EXTRA CHROMOSOME 21 ; 4.1. Protective Effects Against Solid Malignancy 327 $a4.2. DS and Diabetic Retinopathy4.3. Anticancer Therapy; 4.4. Anti-Inflammatory Effect; 4.5. Vascular Anomalies; 4.6. Neuroprotective Effect!!!; 4.7. Lucky Mothers??; 5. GENE THERAPY IN DS: SILENCING THE EXTRA CHROMOSOME; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Neonates with Down Syndrome ; 1. INTRODUCTION; 2. DIAGNOSIS OF DOWN SYNDROME; 2.1. Antenatal Diagnosis; 2.1.1. Prenatal Screening ; 2.1.2. Invasive Prenatal Diagnosis; 2.2. Postnatal Diagnosis; 2.3. Informing the Parents; 3. GROWTH AND DEVELOPMENTAL CHARACTERISTICS OF NEONATES WITH DS 327 $a4. MEDICAL PROBLEMS COMMON IN NEONATES WITH DS4.1. Congenital Heart Diseases; 4.2. Gastrointestinal Abnormalities; 4.3. Upper Airway Abnormalities; 4.4. Respiratory Abnormalities; 4.5. Endocrine Disorders; 4.6. Ophthalmic Disorders; 4.7. Hematologic Disorders; 4.8. Orthopedic Disorders; 4.9. Urinary Tract Disorders; 4.10. Dermatological Disorders; 4.11. Neurological Disorders; 4.12. Dental Disorders; 5. FEEDING NEONATE AND INFANT WITH DS; 5.1. Breastfeeding; 5.2. Bottle Feeding; 5.3. Weaning; 5.4. Feeding Problems for Neonates and Infants 327 $a5.5. Nutritional Intervention in Neonates and Infants with DS 606 $aDown syndrome 606 $aChild development 606 $aDown syndrome$xPatients 608 $aElectronic books. 615 0$aDown syndrome. 615 0$aChild development. 615 0$aDown syndrome$xPatients. 702 $aAl-Biltagi$b Mohammed 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910460732903321 996 $aDown syndrome children-- and update$92246055 997 $aUNINA LEADER 01019nam a2200253 i 4500 001 991001579259707536 005 20020503123211.0 008 981119s1949 it ||| | ita 035 $ab10241280-39ule_inst 035 $aLE01280521$9ExL 040 $aDip.to Lingue$bita 100 1 $aPisani, Vittore$0157026 245 10$aGlottologia indeuropea :$bmanuale di grammatica comparata delle lingue indeuropee, con speciale riguardo del greco e del latino /$cVittore Pisani 250 $a4. ed. riveduta 260 $aTorino :$bRosenberg & Sellier,$cc1949-c1971 300 $axlvi,325 p. ;$c24 cm. 650 4$aGrammatica comparata - Lingue indoeuropee 650 4$aLingue indoeuropee - Grammatica comparata 907 $a.b10241280$b21-09-06$c27-06-02 912 $a991001579259707536 945 $aLE012 415 PIS$g1$i2012000004627$lle012$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i10291337$z27-06-02 996 $aGlottologia indeuropea$9134130 997 $aUNISALENTO 998 $ale012$b01-01-98$cm$da $e-$fita$git $h0$i1