LEADER 00924nam0-22002891i-450- 001 990004653410403321 005 19990530 010 $a91-7042-096-3 035 $a000465341 035 $aFED01000465341 035 $a(Aleph)000465341FED01 035 $a000465341 100 $a19990530g19839999km-y0itay50------ba 101 0 $aita 105 $af-------00--- 200 1 $a<>manteau symbolique$eEtude sur les couples votifs en terre cuite assis sous un meme manteau$fpar Britt Marie Fridh-Haneson.- 210 $aStockholm$cAstrom$d1983. 215 $a89 p., 24 c. di tav.$d30 cm 225 1 $aSkrifter utgivna av Svenska Institutet i Rom$iSeries in 4.$v40 700 1$aFridh-Haneson,$bBritt Marie$0185177 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990004653410403321 952 $aCONT.56(40)$bBibl.60142$fFLFBC 959 $aFLFBC 996 $aManteau symbolique$9553572 997 $aUNINA LEADER 05328nam 2200697 450 001 9910460672103321 005 20200520144314.0 010 $a0-12-801361-3 035 $a(CKB)3710000000346456 035 $a(EBL)1934473 035 $a(SSID)ssj0001430290 035 $a(PQKBManifestationID)11820981 035 $a(PQKBTitleCode)TC0001430290 035 $a(PQKBWorkID)11469740 035 $a(PQKB)11245352 035 $a(MiAaPQ)EBC1934473 035 $a(Au-PeEL)EBL1934473 035 $a(CaPaEBR)ebr11014738 035 $a(CaONFJC)MIL732176 035 $a(OCoLC)902956991 035 $a(EXLCZ)993710000000346456 100 $a20150212h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAdvances in cancer research$hVolume 125$iABC transporters and cancer /$fedited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others] 205 $aFirst edition. 210 1$aLondon, England :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (280 p.) 300 $aDescription based upon print version of record. 311 $a1-336-00894-6 311 $a0-12-801251-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFront Cover; ABC Transporters and Cancer; Copyright; Dedication; Contents; Contributors; Preface; Chapter 1: Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition; 1. Introduction to Apical ABC Transporters; 2. Impact of Apical ABC Transporters on Intestinal Absorption of Oral Chemotherapeutic Drugs; 2.1. Apical ABC transporters affecting the oral bioavailability of taxanes; 2.1.1. ABCB1 and oral taxane availability; 2.1.2. ABCC2 and oral taxane availability; 2.1.3. ABCB1 inhibitors to improve taxane oral availability 327 $a2.1.4. Assessing CNS toxicity risks of using ABCB1 inhibitors to improve oral taxane availability2.1.5. Possible effects of ABCB1 inhibitors on enhancing taxane antitumor efficacy; 2.2. Apical ABC transporters in the oral bioavailability of rationally designed anticancer drugs; 2.2.1. Tyrosine kinase inhibitors; 2.2.2. PARP inhibitors; 2.2.3. Chemical inhibition of transporters to increase oral availability of rationally designed anticancer drugs; 2.2.4. Importance of the sensitivity and specificity of in vitro assays used to assess ABC transporter substrates 327 $a3. Impact of Apical ABC Transporters on Brain Disposition of Oral Chemotherapeutic Drugs3.1. Does the BBB matter in drug delivery to brain tumors?; 3.2. Apical efflux transporters in the BBB affecting brain accumulation of anticancer drugs; 3.2.1. Drugs affected mostly by Abcb1a but also by Abcg2 in their brain accumulation; 3.2.2. Drugs only affected by Abcb1a in their brain accumulation; 3.2.3. Drugs affected mostly by Abcg2 but also by Abcb1a in their brain accumulation; 3.2.4. Three different apical BBB ABC efflux transporters affect brain accumulation of some camptothecins 327 $a3.2.5. Models to explain the disproportionate effect of combined deficiency of Abcb1 and Abcg2 on brain accumulation of s...3.2.6. Why are many rationally designed anticancer drugs still ABCB1 and/or ABCG2 substrates?; 3.2.7. Limitations of knockout mouse models to study ABC transporter functions at the BBB; 3.2.8. Tissue and cellular context may affect the in vivo impact of apical ABC efflux transporters; 3.2.9. Use of chemical inhibitors to enhance brain accumulation of ABC transporter substrate drugs; 4. Concluding Remarks; References 327 $aChapter 2: Regulation of ABC Transporters Blood-Brain Barrier: The Good, the Bad, and the Ugly1. Introduction; 2. Blood-Brain Barriers; 2.1. Assessing blood-brain barrier function; 3. ABC Transporters at the Blood-Brain Barrier; 4. The Bad and the Ugly: Mechanisms that Increase Transporter Expression and Reduce Drug Delivery to the CNS; 4.1. Xenobiotic-activated transcription factors; 4.2. Stress-activated transcription factors; 4.3. Disease; 5. The Good: Mechanisms that Reduce Transporter Activity/Expression and Have the Potential to Improve Drug Delivery to th...; 5.1. P-glycoprotein 327 $a5.2. BCRP 330 $a ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.

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