LEADER 04562nam 2200649 450 001 9910460249603321 005 20200520144314.0 010 $a1-908818-68-9 010 $a1-907568-47-6 035 $a(CKB)3710000000316671 035 $a(EBL)1888544 035 $a(SSID)ssj0001464907 035 $a(PQKBManifestationID)12644139 035 $a(PQKBTitleCode)TC0001464907 035 $a(PQKBWorkID)11459331 035 $a(PQKB)10878139 035 $a(MiAaPQ)EBC1888544 035 $a(Au-PeEL)EBL1888544 035 $a(CaPaEBR)ebr10996817 035 $a(CaONFJC)MIL785092 035 $a(OCoLC)898422306 035 $a(EXLCZ)993710000000316671 100 $a20150106h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aOral delivery of insulin /$fThundiparambil Azeez Sonia, Chandra P. Sharma 210 1$aCambridge, England :$cWoodhead Publishing,$d2014. 210 4$dİ2014 215 $a1 online resource (361 p.) 225 1 $aWoodhead Publishing Series in Biomedicine ;$vNumber 41 300 $aDescription based upon print version of record. 311 $a0-08-101625-5 320 $aIncludes bibliographical references and index. 327 $aCover; Oral Delivery of Insulin; Copyright; Contents; List of figures and tables; About the authors; 1 Diabetes mellitus - an overview; 1.1 Diabetes mellitus - an introduction; 1.2 Glucose homeostasis; 1.3 Types of diabetes; 1.4 Symptoms of diabetes; 1.5 Complications of diabetes; 1.6 Diagnosis of diabetes mellitus; 1.7 Therapy for diabetes; 1.8 Noninsulin treatment options of type 1 diabetes; 1.9 Treatment options of type 2 diabetes; 1.10 Conclusion; 1.11 References; 2 Routes of administration of insulin; 2.1 Current approach for the delivery of insulin 327 $a2.2 Routes of administration of insulin2.3 Conclusion; 2.4 References; 3 Oral insulin delivery - challenges and strategies; 3.1 Oral delivery of insulin; 3.2 Barriers to oral delivery of insulin; 3.3 Strategies and alternatives to improve oral insulin delivery; 3.4 Conclusion; 3.5 References; 4 Experimental techniques involved in the development of oral insulin carriers; 4.1 Introduction; 4.2 Polymeric nanoparticles; 4.3 Physicochemical characterization of nanoparticles; 4.4 Biological evaluation; 4.5 In vitro method for assessing drug permeability; 4.6 In vivo study of oral insulin 327 $a4.7 Biodistribution studies4.8 Conclusion; 4.9 References; 5 Lipids and inorganic nanoparticles in oral insulin delivery; 5.1 Lipid-based systems for oral delivery of insulin; 5.2 Liposomes; 5.3 Solid lipid nanoparticles; 5.4 Nanostructured lipid carriers; 5.5 Niosomes; 5.6 Archaeosomes; 5.7 Cubic nanoparticles (cubosomes); 5.8 Aquasomes; 5.9 Inorganic nanoparticles as carriers for oral insulin delivery; 5.10 Conclusion; 5.11 References; 6 Polymers in oral insulin delivery; 6.1 Introduction; 6.2 Characteristics of an ideal oral insulin carrier; 6.3 Polymers in oral insulin delivery 327 $a6.4 Natural polymers6.5 Synthetic polymers; 6.6 Conclusion; 6.7 References; 7 Summary and future perspectives for oral insulin delivery; 7.1 Introduction; 7.2 Technologies developed for clinical applications of oral insulin delivery; 7.3 Conclusions and future perspectives; 7.4 References; Index 330 $aDiabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and 410 0$aWoodhead Publishing series in biomedicine ;$vNumber 41. 606 $aInsulin$xTherapeutic use$xAdministration 606 $aDiabetes$xOral therapy 608 $aElectronic books. 615 0$aInsulin$xTherapeutic use$xAdministration. 615 0$aDiabetes$xOral therapy. 676 $a616.462061 700 $aSonia$b Thundiparambil Azeez$0965418 702 $aSharma$b Chandra P. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910460249603321 996 $aOral delivery of insulin$92190367 997 $aUNINA