LEADER 04539nam 2200697Ia 450 001 9910460023003321 005 20200520144314.0 010 $a1-283-07277-7 010 $a9786613072771 010 $a0-231-52552-4 024 7 $a10.7312/stoc15212 035 $a(CKB)2670000000079073 035 $a(EBL)908342 035 $a(OCoLC)818855877 035 $a(SSID)ssj0000540550 035 $a(PQKBManifestationID)12214840 035 $a(PQKBTitleCode)TC0000540550 035 $a(PQKBWorkID)10597975 035 $a(PQKB)11247977 035 $a(StDuBDS)EDZ0000455016 035 $a(MiAaPQ)EBC908342 035 $a(DE-B1597)459360 035 $a(OCoLC)714301737 035 $a(OCoLC)979909905 035 $a(DE-B1597)9780231525527 035 $a(Au-PeEL)EBL908342 035 $a(CaPaEBR)ebr10457818 035 $a(CaONFJC)MIL307277 035 $a(EXLCZ)992670000000079073 100 $a20110416d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe quest for the cures$b[electronic resource] $ethe science, stories and struggles behind the next generation of medicines /$fBrent R. Stockwell 210 $aNew York $cColumbia University Press$d2011 215 $a1 online resource (289 p.) 300 $aDescription based upon print version of record. 311 $a0-231-15213-2 311 $a0-231-15212-4 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tContents -- $tList of Illustrations -- $tPreface -- $tAcknowledgments -- $tAbbreviations -- $tPart One. The Vanishing Cures -- $t1. The Drug Discovery Crisis -- $t2. A New Science of Molecules -- $t3. The Birth of the First Cancer Drugs -- $t4. A New Company Creating Drug Combinations -- $t5. The Undruggable RAS Protein -- $t6.The Druggable Genome -- $tPart Two. The Path to the Next Generation of Medicines -- $t7. Peering Inside Proteins -- $t8. The Nature of Interactions Between Proteins -- $t9. From Protein- Protein Interactions to Personalized Medicines -- $t10. A Revolution in Peptide Synthesis -- $t11. A Vast Array of Drug Candidates -- $t12. Moving Outside the Small Molecule Box -- $t13. Accelerating the Arrival of Next- Generation Drugs -- $tNotes -- $tGlossary -- $tIndex 330 $aAfter more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century.Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research. Scientists such as Stockwell are now developing methods to combat these complexities—technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules—all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures. 606 $aDrug development 606 $aDrugs$xDesign 606 $aProteins$xMetabolism 608 $aElectronic books. 615 0$aDrug development. 615 0$aDrugs$xDesign. 615 0$aProteins$xMetabolism. 676 $a615 676 $a615.19 700 $aStockwell$b Brent R$01049499 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910460023003321 996 $aThe quest for the cures$92478564 997 $aUNINA