LEADER 02329nam 2200565 450 001 9910459970503321 005 20200520144314.0 010 $a80-246-2584-9 035 $a(CKB)3710000000320480 035 $a(EBL)3319782 035 $a(SSID)ssj0001469320 035 $a(PQKBManifestationID)11849263 035 $a(PQKBTitleCode)TC0001469320 035 $a(PQKBWorkID)11527840 035 $a(PQKB)10668127 035 $a(MiAaPQ)EBC1996715 035 $a(Au-PeEL)EBL1996715 035 $a(CaPaEBR)ebr10997448 035 $a(OCoLC)894276952 035 $a(EXLCZ)993710000000320480 100 $a20150109h20142014 uy 0 101 0 $acze 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe evolution myth $eor, the genes cry out their urgent song, Mister Darwin got it wrong /$fJir?i? A. Mejsnar ; illustrations by Jir?i? Franta ; english translation by Derek Paton ; edited by Martin Janec?cek ; cover and layout by Jan Sery?ch 210 1$a[Prague, Czech Republic] :$cKarolinum,$d2014. 210 4$d©2014 215 $a1 online resource (115 p.) 300 $aDescription based upon print version of record. 311 $a80-246-2520-2 320 $aIncludes bibliographical references and index. 327 $a""Contents""; ""Preface""; ""Chapter I. Man in Natural Classification""; ""Chapter II. The Age of Man""; ""Chapter III. Cro-Magnons and Neanderthals""; ""Chapter IV. The Origin of Man ""; ""Chapter V. On the Origin of Species""; ""Chapter VI. The Idea Leading to Man""; ""Epilogue""; ""References""; ""Glossary""; ""Appendix 1. Mitochondrial DNA (mtDNA)""; ""Appendix 2. Radiochemical dating methods""; ""Appendix 3. DNA structure and basic function""; ""Appendix 4. An excursion into a???heterocyclic chemistrya???""; ""About the author""; ""Index"" 606 $aEvolution (Biology) 608 $aElectronic books. 615 0$aEvolution (Biology) 676 $a575 700 $aMejsnar$b Jr?i? A.$0908282 702 $aFranta$b Jir?i? 702 $aPaton$b Derek 702 $aJanec?ek$b Martin 702 $aJan Sery?ch 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910459970503321 996 $aThe evolution myth$92031437 997 $aUNINA LEADER 04482nam 22007095 450 001 9910300061503321 005 20251113201511.0 010 $a3-642-54379-0 024 7 $a10.1007/978-3-642-54379-1 035 $a(CKB)3710000000119198 035 $a(EBL)1731263 035 $a(OCoLC)884014037 035 $a(SSID)ssj0001242738 035 $a(PQKBManifestationID)11827365 035 $a(PQKBTitleCode)TC0001242738 035 $a(PQKBWorkID)11260051 035 $a(PQKB)10353945 035 $a(MiAaPQ)EBC1731263 035 $a(DE-He213)978-3-642-54379-1 035 $a(PPN)17877930X 035 $a(EXLCZ)993710000000119198 100 $a20140527d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFilaggrin $eBasic Science, Epidemiology, Clinical Aspects and Management /$fedited by Jacob P. Thyssen, Howard I. Maibach 205 $a1st ed. 2014. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014. 215 $a1 online resource (362 p.) 300 $aDescription based upon print version of record. 311 08$a3-642-54378-2 320 $aIncludes bibliographical references at the end of each chapters. 327 $aBASIC SCIENCE: Mutations in the Filaggrin Gene -- Morphology of Normal and Filaggrin Depleted Epidermis -- Function of Filaggrin and Its Metabolites -- Influence On Skin Lipids -- Inflammatory Driven Depletion of Filaggrin Proteins -- Animal Models -- In Vitro Models -- EPIDEMIOLOGY: Prevalence Rates In Different Races -- Gene-Environment Interactions -- Heterozygous Advantage -- FILAGGRIN AND SKIN DISEASE: Ichthyosis Vulgaris and Other Disorders of Cornification -- Atopic Dermatitis -- Allergic Contact Dermatitis -- Irritant Contact Dermatitis -- Hand Eczema -- Psoriasis -- Disorders In The Seborrheic Areas -- Infections -- Cancer and Tumors -- Autoimmune and Connective Tissue Disorders -- Pigmentation Disorders -- Sweat Gland Disorders -- Nails and Hair -- FILAGGRIN AND NON-CUTANEOUS DISEASE: Asthma -- Rhinitis -- Food Allergy -- Diabetes -- Cardiac Disease -- Inflammatory Bowel Disease -- Ophthalmic Disease -- Rheumatoid Arthritis -- Cancer -- Vitamin D -- MANAGEMENT. 330 $aFilaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes.  While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract.   Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum.    This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties. 606 $aDermatology 606 $aAllergy 606 $aRespiratory organs$xDiseases 606 $aOphthalmology 606 $aDermatology 606 $aAllergology 606 $aPneumology 606 $aOphthalmology 615 0$aDermatology. 615 0$aAllergy. 615 0$aRespiratory organs$xDiseases. 615 0$aOphthalmology. 615 14$aDermatology. 615 24$aAllergology. 615 24$aPneumology. 615 24$aOphthalmology. 676 $a610 676 $a614.5993 676 $a616.042 676 $a616.2 702 $aThyssen$b Jacob P$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMaibach$b Howard I$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910300061503321 996 $aFilaggrin$91523106 997 $aUNINA