LEADER 05284nam 2200637 450 001 9910459797303321 005 20200520144314.0 010 $a0-12-416583-4 010 $a0-12-416579-6 035 $a(CKB)3710000000312775 035 $a(EBL)1887710 035 $a(SSID)ssj0001454879 035 $a(PQKBManifestationID)11820771 035 $a(PQKBTitleCode)TC0001454879 035 $a(PQKBWorkID)11499339 035 $a(PQKB)10001221 035 $a(MiAaPQ)EBC1887710 035 $a(Au-PeEL)EBL1887710 035 $a(CaPaEBR)ebr10999900 035 $a(CaONFJC)MIL485029 035 $a(OCoLC)898070405 035 $a(EXLCZ)993710000000312775 100 $a20150109h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aChannels, carriers, and pumps $ean introduction to membrane transport /$fWilfred D. Stein, Thomas Litman 205 $aSecond edition. 210 1$aLondon, England :$cAcademic Press,$d2015. 210 4$dİ2015 215 $a1 online resource (423 p.) 300 $aIncludes index. 327 $aFront Cover; Channels, Carriers, and Pumps; Copyright Page; Dedications; Contents; Preface to the First Edition; Preface to the Second Edition; List of Symbols; 1 Structural Basis of Movement Across Cell Membranes; 1.1 Membrane Structure: Electron Microscopy of Biological Membranes; 1.2 Chemical Composition of Biological Membranes; 1.2.1 Membrane Lipids; 1.2.2 Membrane Proteins; 1.2.3 Membrane Carbohydrates; 1.3 Membrane Phospholipid Structures and Their Self-Assembly; 1.4 Phase Transitions in Biological Membranes; 1.5 Membrane Proteins: Their Structure and Arrangement 327 $a1.5.1 Proteins That Span the Membrane Only Once1.5.2 Proteins That Span the Membrane More Than Once; 1.6 Synthesis of Membrane Proteins; 1.7 Quantitation of Membrane Dynamics; 1.8 Traffic Across the Plasma Membrane; 1.9 The Cell Membrane as a Barrier and as a Passage; Suggested Readings; General; Membrane Structure; Membrane Lipids; Liposomes; Membrane Proteins; Membrane Dynamics; Glycophorin; Lactose Permease; Hydropathy Plots; Membrane Protein Structure; Synthesis of Membrane Proteins; Endocytosis, Membrane Turnover; Clathrin-Coated Pits and Caveolae; Lipid Rafts; Cytoskeleton 327 $a2 Simple Diffusion of Nonelectrolytes and Ions2.1 Diffusion as a Random Walk; 2.2 The Electrical Force Acting on an Ion; 2.3 Permeability Coefficients and Partition Coefficients; 2.4 Measurement of Permeability Coefficients; 2.5 Analysis of Permeability Data; 2.6 The Membrane as a Hydrophobic Sieve; 2.7 Osmosis and the Diffusion of Water; 2.8 Comparison of Osmotic and Diffusive Flow of Water; Suggested Readings; General; Diffusion as a Random Walk; Chemical Potential; Electrical Potential; Flux Ratio Test; Permeability and Partition Coefficients; Measurement of Permeability Coefficients 327 $aNMR and ESRUnstirred Layers; Plant Cell Permeabilities; Membrane as a Hydrophobic Sieve; Osmosis and the Diffusion of Water; Water Channels - The Aquaporins; Electroosmosis and Streaming Potential; 3 Ion Channels Across Cell Membranes; 3.1 The Gramicidin Channel; 3.2 The Acetylcholine Receptor Channel; 3.3 Conductances and Cross-Sectional Areas of Single Channels; 3.4 An Experimental Interlude; 3.4.1 Identification of Channels by Patch-Clamping; 3.4.2 Measurements of Membrane Potential by Using Intracellular Microelectrodes or by Following Dye Distribution 327 $a3.5 Diffusion Potentials: Goldman-Hodgkin-Katz Equation3.6 Regulation and Modulation of Channel Opening; 3.6.1 The Potassium Channel of Sarcoplasmic Reticulum; 3.6.2 Sodium and Potassium Channels of Excitable Tissue; 3.6.3 The Cell-to-Cell Channel or Gap Junction; 3.6.4 Regulation and Modulation of Some Other Channels; Suggested Readings; Internet Resources; General; Electrostatic (Born) Free Energy; Gramicidin Channel; Enzyme Kinetics; Acetylcholine Receptor; Cloning and Molecular Biology; Acetylcholine Receptor Structure; Ionic Diffusion; Ligand-gated Ion Channels 327 $aCharge Effects on Channel Conductance 330 $a An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in 606 $aBiological transport$xRegulation$vSoftware 606 $aBiological transport, Active$vLaboratory manuals 608 $aElectronic books. 615 0$aBiological transport$xRegulation 615 0$aBiological transport, Active 676 $a572.696 700 $aStein$b Wilfred D.$091351 702 $aLitman$b Thomas 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910459797303321 996 $aChannels, carriers, and pumps$92160831 997 $aUNINA