LEADER 05312nam 2200661 450 001 9910459790903321 005 20200520144314.0 010 $a0-19-932588-X 035 $a(CKB)3710000000331774 035 $a(EBL)1920742 035 $a(SSID)ssj0001401938 035 $a(PQKBManifestationID)12596391 035 $a(PQKBTitleCode)TC0001401938 035 $a(PQKBWorkID)11357721 035 $a(PQKB)11674804 035 $a(MiAaPQ)EBC1920742 035 $a(Au-PeEL)EBL1920742 035 $a(CaPaEBR)ebr11006375 035 $a(CaONFJC)MIL691752 035 $a(OCoLC)900346888 035 $a(EXLCZ)993710000000331774 100 $a20150127h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aExplanation in causal inference $emethods for mediation and interaction /$fTyler J. VanderWeele 210 1$aNew York :$cOxford University Press,$d2015. 210 4$d©2015 215 $a1 online resource (729 p.) 300 $aDescription based upon print version of record. 311 $a1-322-60470-3 311 $a0-19-932587-1 320 $aIncludes bibliographical references and index. 327 $aCover; Explanation in Causal Inference; Copyright; Dedication; Contents; Preface; Part 1 Mediation Analysis; 1 Explanation and Mechanism; 1.1 Causal Inference and Explanation; 1.2 Forms of Explanation and Types of Mechanisms; 1.3 Motivations for Assessing Mediation, Interaction, and Interference; 1.4 Organization of this Book; 2 Mediation: Introduction and Regression-Based Approaches; 2.1 Classic Regression Approach to Mediation Analysis; 2.2 Counterfactual Approach to Mediation Analysis: Continuous Outcomes; 2.3 Assumptions about Confounding; 2.4 Binary and Count Outcomes 327 $a2.5 Binary Mediators2.6 Comparison of Approaches: Product-of-Coefficient and Difference Methods; 2.7 Description of the SAS Macro; 2.8 Description of the SPSS Macro; 2.9 Description of the Stata Macro; 2.10 Hypothetical Example with Output; 2.11 Empirical Example in Genetic Epidemiology; 2.12 When to Include an Exposure--Mediator Interaction; 2.13 Proportion Mediated; 2.14 Proportion Eliminated; 2.15 Study Design and Mediation Analysis; 2.16 Counterfactual Notation for Natural Direct and Indirect Effects; 2.17 An Alternative Regression-Based Estimation Approach Using Simulations 327 $a2.18 Code for the Simulation-Based Approach in R2.19 Discussion; 3 Sensitivity Analysis for Mediation; 3.1 Sensitivity Analysis for Unmeasured Confounding for Total Effects; 3.2 Sensitivity Analysis for Unmeasured Confounding for Controlled Direct Effects; 3.3 Sensitivity Analysis for Unmeasured Confounding for Natural Direct and Indirect Effects; 3.4 Sensitivity Analysis Using Two Trials; 3.5 Sensitivity Analysis for Direct and Indirect Effects in the Presence of Measurement Error; 3.6 Discussion; 4 Mediation Analysis with Survival Data 327 $a4.1 Earlier Literature on Mediation Analysis with Survival Models4.2 Mediation Analysis with an Accelerated Failure Time Model; 4.3 Mediation Analysis with a Proportional Hazards Model; 4.4 Mediation with an Additive Hazard Model; 4.5 A Weighting Approach to Direct and Indirect Effects with Survival Outcomes; 4.6 Sensitivity Analysis with Survival Data; 4.7 Discussion; 5 Multiple Mediators; 5.1 Regression-Based Approaches to Multiple Mediators; 5.2 A Weighting Approach to Multiple Mediators; 5.3 Controlled Direct Effects and Exposure-Induced Confounding 327 $a5.4 Effect Decomposition with Exposure-Induced Confounding5.5 Path-Specific Effects; 5.6 Sensitivity Analysis for Exposure-Induced Confounding; 5.7 Discussion; 6 Mediation Analysis with Time-Varying Exposures and Mediators; 6.1 Notation and Definitions; 6.2 Controlled Direct Effects with Time-Varying Exposures and Mediators; 6.3 Natural Direct and Indirect Effects and their Randomized Interventional Analogues with Time-Varying Exposures and Mediators; 6.4 Counterfactual Analysis of MacKinnon's Three-Wave Mediation Model; 6.5 Discussion; 7 Selected Topics in Mediation Analysis 327 $a7.1 Other Estimation Approaches 330 $aThe book provides an accessible but comprehensive overview of methods for mediation and interaction. There has been considerable and rapid methodological development on mediation and moderation/interaction analysis within the causal-inference literature over the last ten years. Much of this material appears in a variety of specialized journals, and some of the papers are quite technical. There has also been considerable interest in these developments from empirical researchers in the social and biomedical sciences. 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