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101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aGene transfer and the ethics of first-in-human research $elost in translation /$fJonathan Kimmelman$b[electronic resource]
210  1$aCambridge :$cCambridge University Press,$d2010.
215   $a1 online resource (xi, 205 pages) $cdigital, PDF file(s)
300   $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
311   $a0-521-69084-6 
311   $a0-521-87059-3 
320   $aIncludes bibliographical references and index.
327   $aIntroduction: gene transfer lost in translation -- What is gene transfer? -- Safety, values, and legitimacy: the protean nature of risk in translational trials -- Taming uncertainty: risk and gene-transfer clinical research -- Succor or suckers? Benefit, risk, and the therapeutic misconception -- Looking backward: a model value for translational trials -- The chasm: the ethics of initiating first-in-human clinical trials -- Tropic of cancers: gene transfer in resource-poor settings -- Great expectations and hard times: expectation management in gene transfer -- Something in the sight adjusts itself: conclusions.
330   $aHuman gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions.
517 3 $aGene Transfer & the Ethics of First-in-Human Research
606   $aGene therapy$xMoral and ethical aspects
606   $aClinical trials$xMoral and ethical aspects
615  0$aGene therapy$xMoral and ethical aspects.
615  0$aClinical trials$xMoral and ethical aspects.
676   $a615.8/95
700   $aKimmelman$b Jonathan$01050649
801  0$bUkCbUP
801  1$bUkCbUP
906   $aBOOK
912   $a9910459557003321
996   $aGene transfer and the ethics of first-in-human research$92480600
997   $aUNINA