LEADER 04245nam 2200757 a 450 001 9910459553303321 005 20200520144314.0 010 $a1-282-78627-X 010 $a9786612786273 010 $a90-474-2580-4 024 7 $a10.1163/ej.9789004172333.i-441 035 $a(CKB)2670000000046159 035 $a(EBL)583763 035 $a(OCoLC)668368034 035 $a(SSID)ssj0000417471 035 $a(PQKBManifestationID)11289696 035 $a(PQKBTitleCode)TC0000417471 035 $a(PQKBWorkID)10367787 035 $a(PQKB)11168796 035 $a(MiAaPQ)EBC583763 035 $a(OCoLC)500820578 035 $a(nllekb)BRILL9789047425809 035 $a(PPN)174399189 035 $a(Au-PeEL)EBL583763 035 $a(CaPaEBR)ebr10419778 035 $a(CaONFJC)MIL278627 035 $a(EXLCZ)992670000000046159 100 $a20100205d2010 uy 0 101 0 $aeng 135 $aurun| uuuua 181 $ctxt 182 $cc 183 $acr 200 00$aExtraterritorial immigration control$b[electronic resource] $elegal challenges /$fedited by Bernard Ryan, Valsamis Mitsilegas 210 $aLeiden ;$aBoston $cMartinus Nijhoff Publishers$d2010 215 $a1 online resource (459 p.) 225 1 $aImmigration and asylum law and policy in Europe ;$vv. 21 300 $aDescription based upon print version of record. 311 $a90-04-17233-5 320 $aIncludes bibliographical references (p. [431]-445) and index. 327 $aExtraterritorial immigration control : what role for legal guarantees? / Bernard Ryan -- Extraterritorial immigration control in the 21st century : the individual and the state transformed / Valsamis Mitsilegas -- The concept of state jurisdiction and the applicability of the non-refoulement principle to extraterritorial interception measures / Anja Klug and Tim Howe -- The international law of the sea and migration control / Richard Barnes -- The legal framework concerning the smuggling of migrants at sea under the UN protocol on the smuggling of migrants by land, sea and air / Tom Obokata -- Europe beyond its borders : refugee and human rights protection in extraterritorial immigration control / Maarten den Heijer -- Extraterritorial migration control and human rights : preserving the responsibility of the EU and its member states / Evelien Brouwer -- Extraterritorial border controls in the EU : the role of Frontex in operations at sea / Anneliese Baldaccini -- The transformation of European border controls / Elspeth Guild and Didier Bigo -- Migration control at sea : the Italian case / Alessia di Pascale -- Extraterritorial strategies to tackle irregular immigration by sea : a Spanish perspective / Paula Garcia Andrade -- Controlling migration by sea : the Australian case / Susan Kneebone -- US migrant interdiction practices in international and territorial waters / Niels Frenzen -- The UK and extraterritorial immigration control : entry clearance and juxtaposed control / Gina Clayton. 330 $aThis work analyses the legal challenges posed by contemporary practices of extraterritorial immigration control: visas, pre-embarkation checks and the interception of irregular migrants. It examines the international law framework, and provides case-studies from Europe, Australia and the United States. 410 0$aImmigration and asylum law and policy in Europe ;$vv. 21. 606 $aEmigration and immigration law 606 $aMaritime law 606 $aExterritoriality 606 $aEmigration and immigration law$zEurope 606 $aMaritime law$zEurope 606 $aInternational and municipal law$zEurope 608 $aElectronic books. 615 0$aEmigration and immigration law. 615 0$aMaritime law. 615 0$aExterritoriality. 615 0$aEmigration and immigration law 615 0$aMaritime law 615 0$aInternational and municipal law 676 $a342.08/2 701 $aRyan$b Bernard$f1966-$0925065 701 $aMitsilegas$b Valsamis$f1971-$0925066 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910459553303321 996 $aExtraterritorial immigration control$92076224 997 $aUNINA LEADER 05611nam 2200673 a 450 001 9910141482703321 005 20170815095311.0 010 $a1-118-49404-0 010 $a1-299-18826-5 010 $a1-118-49378-8 010 $a1-118-49377-X 035 $a(CKB)2670000000327684 035 $a(EBL)1120718 035 $a(OCoLC)827207580 035 $a(SSID)ssj0000831532 035 $a(PQKBManifestationID)11437142 035 $a(PQKBTitleCode)TC0000831532 035 $a(PQKBWorkID)10873022 035 $a(PQKB)10952289 035 $a(MiAaPQ)EBC1120718 035 $a(DLC) 2012046813 035 $a(PPN)191455482 035 $a(EXLCZ)992670000000327684 100 $a20121107d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aComputational and statistical methods for protein quantification by mass spectrometry$b[electronic resource] /$fIngvar Eidhammer ... [et al.] 210 $aChichester, West Sussex, U.K. $cJohn Wiley & Sons Inc.$d2013 215 $a1 online resource (356 p.) 300 $aDescription based upon print version of record. 311 $a1-119-96400-8 320 $aIncludes bibliographical references and index. 327 $aComputational and Statistical Methods for Protein Quantification by Mass Spectrometry; Contents; Preface; Terminology; Acknowledgements; 1 Introduction; 1.1 The composition of an organism; 1.1.1 A simple model of an organism; 1.1.2 Composition of cells; 1.2 Homeostasis, physiology, and pathology; 1.3 Protein synthesis; 1.4 Site, sample, state, and environment; 1.5 Abundance and expression - protein and proteome profiles; 1.5.1 The protein dynamic range; 1.6 The importance of exact specification of sites and states; 1.6.1 Biological features; 1.6.2 Physiological and pathological features 327 $a1.6.3 Input features1.6.4 External features; 1.6.5 Activity features; 1.6.6 The cell cycle; 1.7 Relative and absolute quantification; 1.7.1 Relative quantification; 1.7.2 Absolute quantification; 1.8 In vivo and in vitro experiments; 1.9 Goals for quantitative protein experiments; 1.10 Exercises; 2 Correlations of mRNA and protein abundances; 2.1 Investigating the correlation; 2.2 Codon bias; 2.3 Main results from experiments; 2.4 The ideal case for mRNA-protein comparison; 2.5 Exploring correlation across genes; 2.6 Exploring correlation within one gene; 2.7 Correlation across subsets 327 $a2.8 Comparing mRNA and protein abundances across genes from two situations2.9 Exercises; 2.10 Bibliographic notes; 3 Protein level quantification; 3.1 Two-dimensional gels; 3.1.1 Comparing results from different experiments - DIGE; 3.2 Protein arrays; 3.2.1 Forward arrays; 3.2.2 Reverse arrays; 3.2.3 Detection of binding molecules; 3.2.4 Analysis of protein array readouts; 3.3 Western blotting; 3.4 ELISA - Enzyme-Linked Immunosorbent Assay; 3.5 Bibliographic notes; 4 Mass spectrometry and protein identification; 4.1 Mass spectrometry; 4.1.1 Peptide mass fingerprinting (PMF) 327 $a4.1.2 MS/MS - tandem MS4.1.3 Mass spectrometers; 4.2 Isotope composition of peptides; 4.2.1 Predicting the isotope intensity distribution; 4.2.2 Estimating the charge; 4.2.3 Revealing isotope patterns; 4.3 Presenting the intensities - the spectra; 4.4 Peak intensity calculation; 4.5 Peptide identification by MS/MS spectra; 4.5.1 Spectral comparison; 4.5.2 Sequential comparison; 4.5.3 Scoring; 4.5.4 Statistical significance; 4.6 The protein inference problem; 4.6.1 Determining maximal explanatory sets; 4.6.2 Determining minimal explanatory sets; 4.7 False discovery rate for the identifications 327 $a4.7.1 Constructing the decoy database4.7.2 Separate or composite search; 4.8 Exercises; 4.9 Bibliographic notes; 5 Protein quantification by mass spectrometry; 5.1 Situations, protein, and peptide variants; 5.1.1 Situation; 5.1.2 Protein variants - peptide variants; 5.2 Replicates; 5.3 Run - experiment - project; 5.3.1 LC-MS/MS run; 5.3.2 Quantification run; 5.3.3 Quantification experiment; 5.3.4 Quantification project; 5.3.5 Planning quantification experiments; 5.4 Comparing quantification approaches/methods; 5.4.1 Accuracy; 5.4.2 Precision; 5.4.3 Repeatability and reproducibility 327 $a5.4.4 Dynamic range and linear dynamic range 330 $a The definitive introduction to data analysis in quantitative proteomics This book provides all the necessary knowledge about mass spectrometry based proteomics methods and computational and statistical approaches to pursue the planning, design and analysis of quantitative proteomics experiments. The author's carefully constructed approach allows readers to easily make the transition into the field of quantitative proteomics. Through detailed descriptions of wet-lab methods, computational approaches and statistical tools, this book covers the full scope of a quantitative experim 606 $aProteomics$xStatistical methods 606 $aMass spectrometry$xData processing 615 0$aProteomics$xStatistical methods. 615 0$aMass spectrometry$xData processing. 676 $a572.636 676 $a572/.636 700 $aEidhammer$b Ingvar$0854303 701 $aBarsnes$b Harald$01240710 701 $aEide$b Geir Egil$01240711 701 $aMartens$b Lennart$01240712 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910141482703321 996 $aComputational and statistical methods for protein quantification by mass spectrometry$92878409 997 $aUNINA